tannic acid
Approved
Feb 22, 1980
Tannic acid is a specific form of tannin, a type of polyphenol. Its weak acidity (pKa around 6) is due to the numerous phenol groups in the structure. The chemical formula for commercial tannic acid is often given as C76H52O46, which corresponds with decagalloyl glucose, but in fact it is a mixture of polygalloyl glucoses or polygalloyl quinic acid esters with the number of galloyl moieties per molecule ranging from 2 up to 12 depending on the plant source used to extract the tannic acid. Commercial tannic acid is usually extracted from any of the following plant parts: Tara pods (Caesalpinia spinosa), gallnuts from Rhus semialata or Quercus infectoria or Sicilian sumac leaves (Rhus coriaria). — Wikipedia
Clinical trial activity
2 trials · 3 clinical orgs · 1 marketing orgs
Earliest trial started Aug 1, 2007 (NCT00521703)
Timeline
1980s
- Feb 22, 1980
Armour & Company — Earliest FDA Approval
- Feb 22, 1980
Evidence of US Marketing
- Feb 22, 1980
Armour & Company — NDA Secondary Org
- Feb 22, 1980
Armour & Company — NDA Organization
2000s
- Jan 1, 2007
Earliest Phase 3 Sponsor(trial)
2020s
- Jan 1, 2021
Earliest Phase 2 Sponsor(trial)
Indications
Approved for
Mechanism of action
- UnclearUnclear
Unclear unclear
Combination products
depinar
Approval history
- approvedFeb 22, 1980
- approvedFeb 22, 1980
Chemistry & pharmacology
SMILES
O=C(OC[C@H]1O[C@@H](OC(=O)c2cc(O)c(O)c(OC(=O)c3cc(O)c(O)c(O)c3)c2)[C@H](OC(=O)c2cc(O)c(O)c(OC(=O)c3cc(O)c(O)c(O)c3)c2)[C@@H](OC(=O)c2cc(O)c(O)c(OC(=O)c3cc(O)c(O)c(O)c3)c2)[C@@H]1OC(=O)c1cc(O)c(O)c(OC(=O)c2cc(O)c(O)c(O)c2)c1)c1cc(O)c(O)c(OC(=O)c2cc(O)c(O)c(O)c2)c1- Mol. weight
- 1701.21 g/mol
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
- Delivery
- Parenteral
- Availability
- Discontinued
Oral
No
Parenteral
Yes
Topical
No
Sources
- WikipediaTannic acid ↗
- NCATS5PG9M8BASQ ↗
- ChEMBLCHEMBL506247 ↗
- NCATS28F9E0DJY6 ↗
Also known as
- e181
- e181
- tannic acid
- tannic acid
- tannic acid
- tannic acid
- tannic acid
- tannic acid
- tannic acid
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT04911777 | Phase 2 | Aug 24, 2021 | SyneuRx International (Taiwan) Corp |
| NCT00521703 | Phase 3 | Aug 1, 2007 | Hospital Infantil Cândido Fontoura, Sao Paulo State University |
Organizations
Research & Development (3)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Hospital Infantil Cândido Fontoura | Academic/Hospital | 1 | 1 | 1 | 2007 |
| Sao Paulo State University | Academic/Hospital | 1 | 0 | 1 | 2007 |
| SyneuRx International (Taiwan) Corp | For profit | 1 | 1 | 1 | 2021 |
Marketing (2)
| Organization | Org type | Relationship | Date |
|---|---|---|---|
| Armour & Company | For profit | NDA2 | Feb 22, 1980 |
| Armour & Company | For profit | NDA | Feb 22, 1980 |