trimebutine
Small moleculeexperimental
Trimebutine is a drug with antimuscarinic and very weak mu opioid agonist effects. It is used for the treatment of irritable bowel syndrome and other gastrointestinal disorders. It is sometimes combined with simethicone as a combination drug. Trimebutine is formulated as a tablet or granules for oral suspension. — Wikipedia
Clinical trial activity
11 trials · 29 clinical orgs · 0 marketing orgs
Phase 1
3
Phase 2
4
Phase 3
2
Phase 4
3
Earliest trial started Dec 1, 2011 (NCT01507922)
Timeline
Indications
Approved for
Studied for
- Abdominal Pain · Phase 1/Phase 2
- Biliary Dyskinesia · Phase 2
- Cholecystitis, Acute · Phase 2
- Colonic Diseases · Phase 2
- Gastroesophageal Reflux · Phase 4
- Gastrointestinal Diseases · Phase 1/Phase 2
- Helicobacter pylori · Phase 4
- Irritable Bowel Syndrome · Phase 4
- Nausea · Phase 3
- Neoplasms · Phase 2
- Pain · Phase 2
- Vomiting · Phase 3
Mechanism of action
- Mu opioid receptorAGONIST
OPRM agonist
Chemistry & pharmacology
Loading structure…
SMILES
CCC(COC(=O)c1cc(OC)c(OC)c(OC)c1)(c1ccccc1)N(C)C- Mol. weight
- 387.48 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Racemic Mixture
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaTrimebutine ↗
- ChEMBLCHEMBL190044 ↗
Also known as
- 2-dimethylamino-2-phenylbutyl 3,4,5-trimethoxybenzoat
- 2-dimethylamino-2-phenylbutyl 3,4,5-trimethoxybenzoat
- gic-1001
- gic-1001
- gic-1001
- timebutine
- trimebutine
- trimebutine
- trimebutine
- trimebutine
- trimebutine
- trimebutine
- (+/-)-trimebutine
- trimébutine
- trimébutine
- trimebutine 3-thiocarbamoylbenzenesulfonate
- trimebutine maleate
- trimebutine maleate
- trimebutine maleate
- trimebutine maleate
- trimebutine maleate
- trimebutine maleate
- trimebutine maleate
- trimebutino
- trimebutino
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06842966 | Phase 2 | Oct 17, 2024 | Valenta Pharm JSC |
| NCT06268964 | Phase 1/Phase 2 (Phase 2) | Sep 1, 2024 | Universidad de Colima |
| NCT04403087 | Phase 4 | Jun 1, 2020 | Hallym University |
| NCT03359499 | Phase 2/Phase 3 (Phase 3) | Aug 12, 2017 | Hospital Britanico |
| NCT03036111 | N/A | Feb 1, 2017 | Mansoura University |
| NCT02986685 | Phase 4 | Nov 1, 2016 | Ankang City Central Hospital, Baoji Central Hospital, Hanzhong Central Hospital, People's Liberation Army of China, Shaanxi Provincial People's Hospital |
| NCT02276768 | Phase 1 | Oct 1, 2014 | Algorithme Pharma Inc, gicare Pharma Inc. |
| NCT01984931 | Phase 3 | Oct 1, 2013 | Chungmu Hospital, CM Chungmu Hospital, Korea United Pharm. Inc. |
| NCT01926444 | Phase 2 | Jul 1, 2013 | Algorithme Pharma Inc, Anaheim Clinical Trials, Avail Clinical Research, Gastroenterology Associates of Orangeburg, SC, gicare Pharma Inc., JSS Medical Research Inc., Mayo Clinic, Mid-Atlantic Medical Research Centers, Hollyword, MD, PharmaTrials, Precision Research Institute, The Center of GI Disorders, Hollwood, FL, USA, Toronto Digestive Disease Associates, Toronto, ON, Canada, University of British Columbia, Yeshiva University |
| NCT01738425 | Phase 1 | Nov 1, 2012 | Algorithme Pharma Inc, gicare Pharma Inc. |
| NCT01507922 | Phase 4 | Dec 1, 2011 | Bukwang Pharmaceutical, Korea University |
Showing 11 of 11 trials
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Organizations
Research & Development (29)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Algorithme Pharma Inc | For profit | 3 | 0 | 2 | 2012 |
| gicare Pharma Inc. | For profit | 3 | 3 | 2 | 2012 |
| Anaheim Clinical Trials | For profit | 1 | 0 | 1 | 2013 |
| Ankang City Central Hospital | Academic/Hospital | 1 | 0 | 1 | 2016 |
| Avail Clinical Research | For profit | 1 | 0 | 1 | 2013 |
| Baoji Central Hospital | Academic/Hospital | 1 | 0 | 1 | 2016 |
| Bukwang Pharmaceutical | For profit | 1 | 1 | 1 | 2011 |
| Chungmu Hospital | Academic/Hospital | 1 | 0 | 1 | 2013 |
| CM Chungmu Hospital | Academic/Hospital | 1 | 1 | 1 | 2013 |
| Gastroenterology Associates of Orangeburg, SC | Academic/Hospital | 1 | 0 | 1 | 2013 |
| Hallym University | Academic/Hospital | 1 | 1 | 1 | 2020 |
| Hanzhong Central Hospital | Academic/Hospital | 1 | 0 | 1 | 2016 |
| Hospital Britanico | Academic/Hospital | 1 | 1 | 1 | 2017 |
| JSS Medical Research Inc. | For profit | 1 | 0 | 1 | 2013 |
| Korea United Pharm. Inc. | For profit | 1 | 0 | 1 | 2013 |
| Korea University | Academic/Hospital | 1 | 0 | 1 | 2011 |
| Mansoura University | Academic/Hospital | 1 | 1 | 1 | 2017 |
| Mayo Clinic | Academic/Hospital | 1 | 0 | 1 | 2013 |
| Mid-Atlantic Medical Research Centers, Hollyword, MD | Academic/Hospital | 1 | 0 | 1 | 2013 |
| People's Liberation Army of China | Government | 1 | 1 | 1 | 2016 |
29 organizations
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