lactobacillus rhamnosus

Cell therapyexperimental

Lacticaseibacillus rhamnosus is a bacterium that originally was considered to be a subspecies of L. casei, but genetic research found it to be a separate species in the L. casei clade, which also includes L. paracasei and L. zeae. It is a short Gram-positive homofermentative facultative anaerobic non-spore-forming rod that often appears in chains. Some strains of L. rhamnosus bacteria are being used as probiotics, and are particularly useful in treating infections of the female urogenital tract, most particularly very difficult to treat cases of bacterial vaginosis. The species Lacticaseibacillus rhamnosus and Limosilactobacillus reuteri are commonly found in the healthy female genito-urinary tract and are helpful to regain control of dysbiotic bacterial overgrowth during an active infection. L. rhamnosus sometimes is used in dairy products such as fermented milk and as non-starter-lactic acid bacterium (NSLAB) in long-ripened cheese. While frequently considered a beneficial organism, L. rhamnosus may not be as beneficial to certain subsets of the population; in rare circumstances, especially those primarily involving weakened immune system or infants, it may cause endocarditis. Despite the rare infections caused by L. rhamnosus, the species is included in the list of bacterial species with qualified presumed safety (QPS) status of the European Food Safety Agency. — Wikipedia

Clinical trial activity

215 trials · 248 clinical orgs · 0 marketing orgs

Phase 1
28
Phase 2
53
Phase 3
24
Phase 4
23

Earliest trial started Mar 1, 2001 (NCT00224432)

Timeline

2000s

  1. Jan 1, 2003

    Earliest Phase 1 Sponsor(trial)

  2. Jan 1, 2004

    Earliest Phase 3 Sponsor(trial)

  3. Jan 1, 2005

    Earliest Phase 2 Sponsor(trial)

Indications

Approved for

Studied for

Mechanism of action

  • microbiotaTissue restoration

    microbiota tissue restoration

Chemistry & pharmacology

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • align
  • ehcf
  • lactobacilli gr-1
  • lactobacillus casei rhamnosus
  • lactobacillus gg
  • lactobacillus gr-1
  • lactobacillus rhamnosu
  • lactobacillus rhamnosus
  • lactobacillus rhamnosus clr2
  • lactobacillus rhamnosus gg
  • lactobacillus rhamnosus gg atcc 53103
  • lactobacillus rhamnosus gr1
  • lactobacillus rhamnosus gr-1
  • lactobacillus rhamnosus, gr-1
  • lactobacillus rhamnosus hn001
  • lactobacillus rhamnosus pb01
  • lactobacillus rhamnosus sp1
  • lactobacillus rhamnosus strain gg
  • lactobacillus rhamnosus w71
  • l. rhamnosus
  • l. rhamnosus fiti
  • l. rhamnosus gg
  • l. rhamnosus gr-1
  • l.rhamnosus r0011 strain

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT07165457N/ASep 4, 2025Clinica Universidad de Navarra
NCT07102836Phase 2Aug 7, 2025Quaid-e-Azam Medical College
NCT07081100N/AAug 5, 2025Wecare Probiotics Co., Ltd.
NCT06990568Phase 4Jun 1, 2025Ilsan Hospital
NCT06873438N/AMar 10, 2025Wecare Probiotics Co., Ltd.
NCT06872320N/AMar 1, 2025Chang Gung University
NCT07154992N/ADec 17, 2024Bioithas SL
NCT06268964Phase 1/Phase 2 (Phase 2)Sep 1, 2024Universidad de Colima
NCT06470906N/AAug 14, 2024Columbia University
NCT06899620N/AJul 1, 2024Wecare Probiotics Co., Ltd.
NCT06629441N/AJun 20, 2024Wecare Probiotics Co., Ltd.
NCT06607562N/AJun 3, 2024Wecare Probiotics Co., Ltd.
NCT07072871N/AApr 1, 2024PT Royal Medikalink Pharmalab
NCT06310733Phase 4Mar 21, 2024Prince of Songkla University
NCT07091955N/AOct 16, 2023Bioithas SL
NCT06429358N/AJun 23, 2023Frontier Medical and Dental College, Abbotabad
NCT07296718Phase 4May 15, 2023Islamia University of Bahawalpur
NCT05674981N/AApr 24, 2023Chung Shan Medical University, GenMont Biotech Incorporation
NCT05791604N/AApr 1, 2023Fudan University
NCT05517928N/AJan 31, 2023Mayo Clinic
Showing 20 of 215 trials
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Organizations

Research & Development (248)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
University of Naples Frederico IIAcademic/Hospital101032008
University of Western OntarioAcademic/Hospital8532007
Harvard UniversityAcademic/Hospital6532009
Medical University of WarsawAcademic/Hospital6622010
Tufts UniversityAcademic/Hospital6532003
Chr HansenFor profit5222007
McMaster UniversityAcademic/Hospital5442013
University of CopenhagenAcademic/Hospital5422014
Wecare Probiotics Co., Ltd.For profit5512024
Department of Veteran AffairsGovernment4432008
Georgetown UniversityAcademic/Hospital4422016
University of TorontoAcademic/Hospital4332005
Baylor UniversityAcademic/Hospital3232008
Canadian Institutes of Health Research (CIHR)Academic/Hospital3032005
Emek Medical CenterAcademic/Hospital3312016
Lallemand SASFor profit3122013
Medical University of GrazAcademic/Hospital3312012
National Institute for Medical Research, TanzaniaGovernment3122007
Shriners Hospitals for ChildrenAcademic/Hospital3222004
University of AntwerpAcademic/Hospital3312016
248 organizations
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