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arbaclofen

Small moleculeexperimental

Arbaclofen placarbil is a prodrug of R-baclofen. Arbaclofen placarbil possesses more favorable pharmacokinetic profile than baclofen, with less fluctuations in plasma drug levels. It was being developed as a potential treatment for patients with GERD and spasticity due to multiple sclerosis; however, in May 2013 XenoPort announced the termination of development because of unsuccessful results in phase III clinical trials. — Wikipedia

Clinical trial activity

28 trials · 28 clinical orgs · 0 marketing orgs

Phase 1
2
Phase 2
25
Phase 3
11
Phase 4
0

Earliest trial started Oct 1, 2005 (NCT00838396)

Timeline

2000s

  1. Jan 1, 2005

    Earliest Phase 2 Sponsor(trial)

2010s

  1. Jan 1, 2011

    Earliest Phase 3 Sponsor(trial)

  2. Jan 1, 2016

    Earliest Phase 1 Sponsor(trial)

Indications

Studied for

Mechanism of action

Chemistry & pharmacology

Loading structure…

SMILES

CC(C)C(=O)O[C@@H](OC(=O)NC[C@H](CC(=O)O)c1ccc(Cl)cc1)C(C)C
Mol. weight
399.87 g/mol
Lipinski Ro5
Pass
Rule of 3
No
Chirality
Single Stereoisomer
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Prodrug

Sources

Also known as

  • 4-chloro-beta-((((2-methyl-1-(2-methyl-1-oxopropoxy)propoxy)carbonyl)amino)methyl)benzenepropanoic acid
  • arbaclofen
  • arbaclofen
  • arbaclofen
  • arbaclofen
  • arbaclofen hydrochloride
  • arbaclofen placarbil
  • arbaclofen placarbil
  • arbaclofen placarbil
  • arbaclofen placarbil
  • arbaclofen placarbil
  • (r)-4-amino-3-(4-chlorophenyl)butan­oic acid
  • (r)-4-amino-3-(4-chlorophenyl)butan­oic acid
  • (r)-baclofen
  • (r)-baclofen
  • stx209
  • stx209
  • xp19986
  • xp19986
  • xp19986
  • xp19986
  • xp-19986
  • xp-19986

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT05179577Phase 3Jan 31, 2023Osmotica Pharmaceutical
NCT04271332Phase 2Mar 31, 2020Clinical Research Associates, Inc.
NCT03887676Phase 2Mar 18, 2019McMaster University, Queen's University, Belfast, University of Toronto, University of Western Ontario
NCT03682978Phase 2Oct 31, 2018Hospital General Universitario Gregorio Marañon, Newcastle University, Robert Debré Hospital, University of Edinburgh, University of Glasgow, Utrecht University
NCT03319732Phase 3Apr 3, 2018Osmotica Pharmaceutical
NCT03594552N/AFeb 1, 2018University of London
NCT03290131Phase 3Jan 28, 2018Osmotica Pharmaceutical
NCT03058237Phase 1Jan 23, 2017Indivior Inc.
NCT02869425Phase 3Jul 1, 2016Osmotica Pharmaceutical
NCT02278328Early Phase 1 (Phase 1)Feb 1, 2016Clinical Research Associates, Inc., Simons Foundation, University of Pennsylvania
NCT02511886Phase 2Sep 1, 2015Indivior Inc.
NCT01844232Phase 3Apr 1, 2013Osmotica Pharmaceutical
NCT01743651Phase 3Nov 1, 2012Osmotica Pharmaceutical
NCT01706523Phase 3Nov 1, 2011Seaside Therapeutics, Inc.
NCT01555333Phase 3Nov 1, 2011Seaside Therapeutics, Inc.
NCT01325220Phase 3Jun 1, 2011Seaside Therapeutics, Inc.
NCT01359566Phase 3May 1, 2011Indivior Inc.
NCT01288716Phase 2May 1, 2011Seaside Therapeutics, Inc.
NCT01282268Phase 3May 1, 2011Seaside Therapeutics, Inc.
NCT01064973Phase 2Feb 1, 2010Seaside Therapeutics, Inc.
Showing 20 of 28 trials
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Organizations

Research & Development (28)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Seaside Therapeutics, Inc.For profit9922008
Indivior Inc.For profit8832005
Osmotica PharmaceuticalFor profit6612012
XenoPort, Inc.For profit4012005
Clinical Research Associates, Inc.For profit2122016
Indiana UniversityAcademic/Hospital2012008
Red Oak PsychiatryAcademic/Hospital2012008
University of California, Los AngelesAcademic/Hospital2012008
University of North Carolina at Chapel HillAcademic/Hospital2012008
University of WashingtonAcademic/Hospital2012008
Vanderbilt UniversityAcademic/Hospital2012008
Harvard UniversityAcademic/Hospital1012008
Hospital General Universitario Gregorio MarañonAcademic/Hospital1012018
McMaster UniversityAcademic/Hospital1012019
Newcastle UniversityAcademic/Hospital1012018
NYS Institute for Basic Research in Developmental DisabilitiesAcademic/Hospital1012008
Queen's University, BelfastAcademic/Hospital1012019
Robert Debré HospitalAcademic/Hospital1012018
Rush UniversityAcademic/Hospital1012008
Simons FoundationAcademic/Hospital1012016
28 organizations
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