calcium carbonate
Small moleculeapproved
Approved
Oct 16, 2000
Calcium carbonate is a chemical compound with the chemical formula CaCO3. It is a common substance found in rocks as the minerals calcite and aragonite, most notably in chalk and limestone, eggshells, gastropod shells, shellfish skeletons and pearls. Materials containing much calcium carbonate or resembling it are described as calcareous. Calcium carbonate is the active ingredient in agricultural lime and is produced when calcium ions in hard water react with carbonate ions to form limescale. It has medical use as a calcium supplement or as an antacid, but excessive consumption can be hazardous and cause hypercalcemia and digestive issues. — Wikipedia
Clinical trial activity
165 trials · 201 clinical orgs · 3 marketing orgs
Phase 1
34
Phase 2
56
Phase 3
31
Phase 4
25
Earliest trial started Apr 1, 1995 (NCT00398606)
Timeline
2000s
- Oct 16, 2000
Johnson and Johnson — Earliest FDA Approval
- Oct 16, 2000
Johnson and Johnson — NDA Secondary Org
- Oct 16, 2000
Johnson and Johnson — NDA Organization
- Jan 1, 2004
Earliest Phase 1 Sponsor(trial)
- Aug 12, 2005
Warner Chilcott — NDA Secondary Org
- Feb 6, 2008
Perrigo — Marketing Organization
Indications
Approved for
Studied for
- Adenoma · Phase 2/Phase 3
- Aflatoxins · Phase 2
- Aging · Phase 2
- Amenorrhea · Phase 4
- Arthralgia · Phase 2
- Arthritis, Juvenile · Phase 2
- Arthritis, Rheumatoid · Phase 4
- Atrial Fibrillation · Early Phase 1
- Bariatric Surgery · Phase 2
- Benign Paroxysmal Positional Vertigo · Phase 4
- Bone Diseases · Phase 4
- Bone Diseases, Metabolic · Phase 4
- Breast Neoplasms · Phase 3
- Calcium Metabolism Disorders · Phase 4
- Chronic Kidney Disease-Mineral and Bone Disorder · Phase 4
- Colitis, Ulcerative · Early Phase 1
- Colonic Neoplasms · Phase 1
- Colorectal Neoplasms · Phase 2/Phase 3
- Crohn Disease · Early Phase 1
- Cystinosis · Phase 3
- Dental Caries · Early Phase 1
- Dentin Sensitivity · Phase 4
- Depression · Phase 4
- Depression, Postpartum · Phase 4
- Diabetes Mellitus · Phase 2
- Diabetes Mellitus, Type 2 · Phase 1/Phase 2
- Diabetic Nephropathies · Phase 2
- Diarrhea · Phase 3
- Dyspepsia · Phase 1
- Endometriosis · Phase 4
- Enteral Nutrition · Phase 4
- Epilepsies, Partial · Phase 3
- Epilepsy · Phase 3
- Fluorosis, Dental · Phase 1
- Fractures, Bone · Phase 1/Phase 2
- Gastroesophageal Reflux · Phase 2
- Gaucher Disease · Phase 2
- General Surgery · Phase 4
- Glucose Intolerance · Phase 1/Phase 2
- Healthy Volunteers · Phase 2
- Heartburn · Phase 2
- Heart Valve Diseases · Phase 4
- Hemodialysis, Home · Phase 4
- Hepatitis B · Phase 4
- Hepatitis B virus · Phase 4
- HIV · Phase 1
- HIV Infections · Phase 2/Phase 3
- Huntington Disease · Phase 2/Phase 3
- Hyperparathyroidism, Secondary · Phase 4
- Hyperphosphatemia · Phase 4
- Hypogonadism · Phase 2
- Hypoparathyroidism · Phase 4
- Kidney Failure, Chronic · Phase 2
- Labor, Induced · Phase 4
- Labor, Obstetric · Phase 4
- Leg Injuries · Phase 1
- Leukemia, Myeloid, Acute · Phase 1
- Liver Cirrhosis · Phase 3
- Lung Neoplasms · Phase 1
- Lymphoma · Phase 3
- Lymphoma, Non-Hodgkin · Phase 3
- Metabolic Syndrome · Phase 2
- Multiple Sclerosis · Phase 4
- Musculoskeletal Diseases · Phase 2
- Neoplasm Metastasis · Phase 1
- Neoplasms · Phase 1
- Obesity · Phase 4
- Obstetric Labor Complications · Phase 2/Phase 3
- Osteoporosis, Postmenopausal · Phase 4
- Osteosarcoma · Phase 1
- Overweight · Phase 4
- Pain · Phase 2
- Parathyroid Hormone · Phase 4
- Performance-Enhancing Substances · Early Phase 1
- Pharmacokinetics · Early Phase 1
- Pharmacological and Toxicological Phenomena · Phase 2
- Pharmacology · Phase 2
- Polycystic Ovary Syndrome · Phase 3
- Polyps · Phase 2/Phase 3
- Postpartum Hemorrhage · Early Phase 1
- Precursor Cell Lymphoblastic Leukemia-Lymphoma · Phase 3
- Pregnancy · Phase 1
- Pregnancy Complications · Phase 3
- Prostatic Neoplasms · Phase 3
- Prostatic Neoplasms, Castration-Resistant · Phase 1
- Quality of Life · Phase 4
- Renal Dialysis · Phase 3
- Renal Insufficiency, Chronic · Phase 4
- Sarcopenia · Phase 2
- Seizures · Phase 3
- Self Efficacy · Phase 2
- Serum · Phase 4
- Sjogren's Syndrome · Phase 4
- Skeleton · Phase 1
- Sleep Deprivation · Phase 4
- Spinal Cord Injuries · Phase 2
- Stomach Diseases · Phase 2
- Tenofovir · Phase 4
- Tooth Bleaching · Phase 4
- Urinary Tract Infections · Phase 2/Phase 3
- Uterine Contraction · Phase 2/Phase 3
- Vascular Diseases · Phase 2
- Vascular Stiffness · Phase 2
- Vitamin D · Phase 4
- Vitamin D Deficiency · Phase 4
Mechanism of action
- CalciumSupplementation
Calcium supplementation
Combination products
actonel with calcium (copackaged)
with risedronate
pepcid complete
Approval history
- approvedOct 16, 2000
Chemistry & pharmacology
Loading structure…
SMILES
O=C([O-])[O-].[Ca+2]- Mol. weight
- 100.09 g/mol
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
- Delivery
- Oral
- Availability
- Over the Counter
Oral
Yes
Parenteral
No
Topical
No
Sources
- WikipediaCalcium carbonate ↗
- NCATS2E32821G6I ↗
- ChEMBLCHEMBL1200539 ↗
Also known as
- adcal
- albacar
- albacar
- cacit
- caco3
- caco3
- calc 500
- calcette
- calcichew
- calcichew fte
- calcidrink
- calciumcarbonat
- calciumcarbonat
- calcium carbonate
- calcium carbonate
- calcium carbonate
- calcium carbonate
- calcium carbonate
- calcium carbonate
- calcium carbonate
- calcium carbonate
- calcium carbonate (1:1)
- calcium carbonate (1:1)
- calcium cardone
- cal-sup
- cal-sup
- carbonate de calcium
- carbonate de calcium
- carbonato de calcio
- carbonato de calcio
- carbonic acid calcium salt
- carbonic acid calcium salt (1:1)
- carbonic acid calcium salt (1:1)
- chalk
- chalk
- chalk
- chalk, precipitated
- chalk, precipitated
- children's mylanta upset stomach relief
- children's mylanta upset stomach relief
- chooz
- chooz
- citrical
- citrical
- e170
- e170
- e 170
- e 170
- gastrolith calcium
- kalziumkarbonat
- kalziumkarbonat
- kohlensaurer kalk
- kohlensaurer kalk
- mylanta soothing lozenges
- mylanta soothing lozenges
- os-cal
- precipitated calcium carbonate
- precipitated calcium carbonate
- precipitated calcium carbonate
- purecal
- remegal
- remegel
- rennie
- rennie
- rennie fruit
- rennie gold
- setlers
- titralac
- tums
- tums
- tums
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06882031 | Phase 1 | Mar 11, 2025 | SDK Therapeutics, Inc., The University of Hong Kong |
| NCT06650930 | Early Phase 1 (Phase 1) | Jan 31, 2025 | Stanford University |
| NCT06728462 | N/A | Dec 14, 2024 | Chang Gung University, Universal Integrated Corp. |
| NCT06547151 | Phase 2 | Nov 30, 2024 | Amorphical Ltd. |
| NCT06580782 | Phase 4 | Nov 18, 2024 | Cornell University |
| NCT06385093 | Phase 4 | Jun 30, 2024 | Chinese Academy of Medical Sciences, Chinese SLE Treatment And Research Group |
| NCT06352775 | N/A | Jun 1, 2024 | Wake Forest University |
| NCT07056062 | Phase 2/Phase 3 (Phase 3) | Apr 30, 2024 | University of California, Irvine |
| NCT06293326 | Phase 1 | Mar 6, 2024 | Bayer |
| NCT06660524 | Phase 4 | Mar 1, 2024 | Chinese Academy of Medical Sciences |
| NCT06383117 | N/A | Oct 17, 2023 | National Center for Advancing Translational Science (NCATS), University of Georgia |
| NCT06025773 | Phase 1 | Sep 8, 2023 | Addpharma Inc. |
| NCT05577507 | Phase 4 | Mar 30, 2023 | Ain Shams University |
| NCT05593627 | Phase 4 | Mar 1, 2023 | China Medical University |
| NCT05571514 | N/A | Jan 31, 2023 | Government of France, University of Lyon |
| NCT05619315 | N/A | Dec 31, 2022 | Cairo University |
| NCT06866561 | N/A | Nov 15, 2022 | Uludag University |
| NCT05424263 | Phase 2 | Sep 29, 2022 | University of Colorado, University of Colorado, Denver |
| NCT05950204 | N/A | Sep 10, 2022 | Government of Mexico, Instituto Mexicano del Seguro Social |
| NCT05488340 | Phase 2/Phase 3 (Phase 3) | Jul 13, 2022 | Locus Biosciences, Parexel |
Showing 20 of 165 trials
Page 1 / 9
Organizations
Research & Development (201)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Merck | For profit | 11 | 9 | 3 | 1995 |
| National Cancer Institute (NCI) | Government | 8 | 2 | 3 | 2002 |
| Amorphical Ltd. | For profit | 7 | 7 | 4 | 2011 |
| Harvard University | Academic/Hospital | 5 | 2 | 2 | 2001 |
| Novartis | For profit | 5 | 2 | 3 | 2006 |
| Creighton University | Academic/Hospital | 4 | 1 | 4 | 2004 |
| Bayer | For profit | 3 | 2 | 3 | 2006 |
| Cairo University | Academic/Hospital | 3 | 3 | 1 | 2018 |
| China Medical University | Academic/Hospital | 3 | 3 | 2 | 2020 |
| GlaxoSmithKline | For profit | 3 | 1 | 2 | 2007 |
| Horizon Pharma | For profit | 3 | 3 | 2 | 2009 |
| Mayo Clinic | Academic/Hospital | 3 | 0 | 1 | 2002 |
| National Institute of Allergy and Infectious Diseases (NIAID) | Government | 3 | 2 | 1 | 2003 |
| National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Government | 3 | 3 | 2 | 2000 |
| Tanta University | Academic/Hospital | 3 | 3 | 1 | 2016 |
| University of Toronto | Academic/Hospital | 3 | 3 | 2 | 2013 |
| Aarhus University | Academic/Hospital | 2 | 1 | 1 | 2016 |
| Chinese Academy of Medical Sciences | Academic/Hospital | 2 | 1 | 1 | 2024 |
| Genzyme | For profit | 2 | 0 | 1 | 2005 |
| Georgetown University | Academic/Hospital | 2 | 1 | 2 | 2003 |
201 organizations
Page 1 / 11
Marketing (4)
| Organization | Org type | Relationship | Date |
|---|---|---|---|
| Johnson and Johnson | For profit | NDA2 | Oct 16, 2000 |
| Johnson and Johnson | For profit | NDA | Oct 16, 2000 |
| Perrigo | For profit | MKTG | Feb 6, 2008 |
| Warner Chilcott | For profit | NDA2 | Aug 12, 2005 |