erythromycin

Trade name: ilosone

Small moleculeapproved

Approved

Jun 24, 1964

Erythromycin ethylsuccinate (E.E.S.®, ERY-PED®) is an ester of erythromycin base and succinic acid. It is suitable for oral administration. Erythromycin is a macrolide antibiotic, produced by Saccharopolyspora erythraea (formerly Streptomyces erythraeus). It acts primarily as a bacteriostatic agent. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins. Erythromycin does not affect nucleic acid synthesis. — NCATS

Clinical trial activity

86 trials · 102 clinical orgs · 76 marketing orgs

Phase 1

Phase 2

Phase 3

Phase 4

Earliest trial started Jan 1, 1985 (NCT00000120)

Timeline

1960s

Jun 24, 1964
Earliest FDA Approval
Jun 24, 1964
Arbor Pharmaceuticals — Marketing Organization
Jun 25, 1964
Hospira — NDA Secondary Org
Jun 29, 1964
Eli Lilly — First NDA Organization
Jun 29, 1964
Eli Lilly — NDA Organization
Apr 2, 1965
Azurity — Marketing Organization
Apr 2, 1965
Azurity — NDA Secondary Org

1970s

Aug 6, 1970
Arbor Pharmaceuticals — NDA Secondary Org
Sep 8, 1972
Ani Pharmaceuticals — Marketing Organization
Jan 16, 1973
Mylan — Marketing Organization
Dec 5, 1974
Bristol-Myers — Marketing Organization
Jan 3, 1975
Eli Lilly — Marketing Organization
Aug 24, 1977
Parke-Davis — Marketing Organization
Aug 24, 1977
Warner Lambert — Marketing Organization
Jun 14, 1979
Watson Pharmaceuticals — Marketing Organization
Nov 29, 1979
Abbott — Marketing Organization
Nov 29, 1979
Abbott — NDA Secondary Org

1980s

Apr 28, 1980
Barr Laboratories — Marketing Organization
Jun 3, 1980
Squibb — NDA Secondary Org
Jan 26, 1981
Mayne Pharma — NDA Secondary Org
Jan 26, 1981
Dr. Reddy's Laboratories — Marketing Organization
Jan 26, 1981
Dr. Reddy's Laboratories — NDA Secondary Org
May 22, 1981
Warner Chilcott — Marketing Organization
Aug 11, 1981
Alpharma — Marketing Organization
Nov 18, 1982
Taro Pharmaceuticals — Marketing Organization
Dec 17, 1982
Life Labs — Marketing Organization
Mar 9, 1983
Squibb — Marketing Organization
Sep 26, 1983
Padagis Us — Marketing Organization
Oct 26, 1984
Bausch Health Companies — Marketing Organization
Oct 26, 1984
Bausch Health Companies — NDA Secondary Org
Jan 1, 1985
Earliest Phase 3 Sponsor(trial)
Jan 10, 1985
Dow Pharmaceutical Sciences — NDA Secondary Org
Jan 24, 1985
Dow Pharmaceutical Sciences — Marketing Organization
Feb 15, 1985
Johnson and Johnson — NDA Secondary Org
Mar 28, 1985
Elkins Sinn — Marketing Organization
Jul 3, 1985
Fougera — Marketing Organization
Jul 3, 1985
Syosset — Marketing Organization
Jul 11, 1985
Merz — Marketing Organization
Jul 25, 1985
Pharmafair — Marketing Organization
Oct 31, 1986
Hospira — Marketing Organization
Oct 21, 1987
Mylan — NDA Secondary Org
Oct 23, 1987
Xttrium Laboratories — Marketing Organization
Oct 23, 1987
Wockhardt — Marketing Organization
Feb 5, 1988
Micro Labs Ltd India — Marketing Organization
Feb 5, 1988
Saptalis Pharmaceuticals — Marketing Organization
Jun 15, 1988
Alta Pharma — Marketing Organization
Sep 14, 1988
Aurobindo Pharma — Marketing Organization
May 9, 1989
Baxalta — Marketing Organization
May 9, 1989
Baxter — Marketing Organization

1990s

Oct 17, 1990
Cosette — Marketing Organization
Oct 17, 1990
ACP Nimble — Marketing Organization
Oct 17, 1990
G & W Laboratories Inc. — Marketing Organization
Aug 23, 1991
Altana — Marketing Organization
Jan 29, 1993
Perrigo — Marketing Organization
Jul 30, 1993
Teva — Marketing Organization
Jan 27, 1994
Bausch & Lomb — Marketing Organization
Jul 18, 1996
Akorn, Inc. — Marketing Organization
Jul 18, 1996
SENTISS — Marketing Organization
Oct 22, 1996
Hi Tech Pharmaceuticals — Marketing Organization
Feb 14, 1997
Renaissance Pharma — Marketing Organization
Jan 1, 1999
Earliest Phase 1 Sponsor(trial)
Jan 1, 1999
Earliest Phase 2 Sponsor(trial)

2000s

Nov 27, 2000
Cutanea Life Sciences, Inc. — Marketing Organization
Nov 27, 2000
Biofrontera Bioscience GmbH — NDA Secondary Org
Mar 29, 2004
Encube Ethicals Pvt. Ltd. — Marketing Organization
Mar 29, 2004
Tolmar Inc. — Marketing Organization

2010s

Sep 18, 2015
Lyne Laboratories — Marketing Organization
Jul 19, 2017
Pharmaceutical Associates — Marketing Organization
Jul 19, 2017
Teligent Pharmaceuticals — Marketing Organization
Mar 9, 2018
Amneal Pharmaceuticals — Marketing Organization
Oct 23, 2019
Par Pharmaceuticals — Marketing Organization
Oct 23, 2019
Bristol-Myers Squibb — Marketing Organization

2020s

Jul 6, 2020
Torrent Pharmaceuticals Limited — Marketing Organization
Sep 17, 2020
Exela Pharma Sciences, LLC. — Marketing Organization
Jun 28, 2021
Cadila Healthcare — Marketing Organization
Feb 14, 2022
Nexus Pharmaceuticals — Marketing Organization
Jul 13, 2022
Alkem Labs Ltd — Marketing Organization
Mar 7, 2023
Zydus Discovery DMCC — Marketing Organization
Aug 24, 2023
Alembic — Marketing Organization

Indications

Approved for

Studied for

Mechanism of action

Bacterial 70S ribosomeINHIBITOR
Bacterial 70S ribosome inhibitor
23S RRNA

Combination products

benzamycin
with benzoyl peroxide
Also known as aktipak
pediazole
with sulfisoxazole
Also known as eryzole

Approval history

approvedJun 24, 1964

Chemistry & pharmacology

Loading structure…

SMILES

CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O

Mol. weight: 733.9268 g/mol
Lipinski Ro5: 2 violation(s)
Rule of 3: No
Chirality: Single Stereoisomer
Inorganic: No
Polymer: No
Delivery: Parenteral
Availability: Prescription Only

Oral

Parenteral

Yes

Topical

Sources

Also known as

3''-o-demethylerythromycin
3''-o-demethylerythromycin
abomacetin
abomacetin
aknemycin
akne-mycin
akne-mycin
akne-mycin
aknemycin plus
anamycin
a/t/s
a/t/s
bristamycin
bristamycin
c-solve-2
c-solve-2
davercin
davercin
e-base
e-base
e.e.s.
e.e.s.
e.e.s. 200
e.e.s. 200
e.e.s. 400
e.e.s. 400
e-glades
e-glades
emgel
emgel
e-mycin
e-mycin
e-mycin e
e-mycin e
eritrocina
eritrocina
eritromicina
eritromicina
eryacne 2
eryacne 4
eryc
eryc
eryc 125
eryc 125
erycette
erycette
eryc sprinkles
eryc sprinkles
eryderm
eryderm
erygel
erygel
erymax
erymax
erymax sprinkle
erymin
erypar
erypar
eryped
eryped
ery-tab
ery-tab
erythomycin
erythomycin
erythra-derm
erythra-derm
erythro 200
erythrocin
erythrocin
erythrocin
erythrocin 500
erythrocin acne pack
erythrocin ethyl succinate
erythrocin stearate
erythrocin stearate
erythroden
erythromycin
erythromycin
erythromycin
erythromycin
erythromycin
erythromycin
erythromycin
erythromycin
erythromycin
erythromycin
erythromycin
erythromycin a
erythromycin a
erythromycin a
erythromycin a 11,12-carbonate
erythromycin a carbonate
erythromycin a carbonate
erythromycin a cyclic 11,12-carbonate
erythromycin-ammonium bituminosulfonate
erythromycin, ammonium bituminosulfonate drug combination
erythromycin c
erythromycin c
erythromycin cyclic carbonate
érythromycine
érythromycine
erythromycin estolate
erythromycin estolate
erythromycin estolate
erythromycin estolate
erythromycin ethylsuccinate
erythromycin ethylsuccinate
erythromycin ethylsuccinate
erythromycin ethylsuccinate
erythromycin ethylsuccinate
erythromycin ethylsuccinate
erythromycin ethyl succinate
erythromycin ethyl succinate
erythromycin ethyl succinate
erythromycin ethyl succinate
erythromycin gluceptate
erythromycin gluceptate
erythromycin gluceptate
erythromycin gluceptate
erythromycin glucoheptonate
erythromycin glucoheptonate
erythromycin glucoheptonate
erythromycin-ichthammol
erythromycin lactobionate
erythromycin lactobionate
erythromycin lactobionate
erythromycin lactobionate
erythromycin lauryl sulfate, propionyl
erythromycin lauryl sulfate, propionyl
erythromycin propionate
erythromycin propionate
erythromycin propionate
erythromycin propionate
erythromycin propionate
erythromycin propionate
erythromycin propionate lauryl sulfate
erythromycin propionate lauryl sulfate
erythromycin stearate
erythromycin stearate
erythromycin stearate
erythromycin stearate
erythromycinum
erythromycinum
erythromycin - zinc acetate
erythromycin, zinc acetate drug combination
erythroped
erythroped
erythroped a
erythroped fte
erythroped fte sf
erythroped pi
erythroped pi sf
erythroped sf
erythro-statin
erythro-statin
erytromycin
erytromycin
e-solve 2
e-solve 2
ethril 250
ethril 250
ethril 500
ethril 500
gallimycin
gallimycin
gallimycin
ilosone
ilosone
ilosone
ilotycin
ilotycin
ilotycin gluceptate
ilotycin gluceptate
isotrexin
kerymax
nyc 0462
oftalmolosa cusi eritromicina
oftalmolosa cusi eritromicina
paediathrocin
paediathrocin
pce
pce
pediamycin
pediamycin
pediamycin 400
pediamycin 400
pfizer-e
pfizer-e
primacine
primacine
propiocine
propionyl eryhthromycin
propionyl erythromicin
propionylerythromycin
propionyl erythromycin lauryl sulfate
propionyl erythromycin lauryl sulfate
retcin
retcin
robimycin
robimycin
rommix 125
rommix 250 ec
rommix 500 ec
r-p mycin
r-p mycin
sansac
sansac
staticin
staticin
stiemycin
stiemycin
superfact
tiloryth
tiloryth
tiloryth
t-stat
t-stat
wyamycin
wyamycin
wyamycin e
wyamycin e
wyamycin s
wyamycin s
zineryt
zineryt

Clinical trials

NCT ID	Phase	Start date	Sponsor(s)
NCT06906757	N/A	Sep 30, 2025	University of Melbourne
NCT07063082	N/A	Jul 7, 2025	Cairo University
NCT06948747	Phase 1	May 6, 2025	AstraZeneca
NCT06917872	Phase 1	Apr 29, 2025	Boehringer Ingelheim
NCT06461429	N/A	Feb 1, 2025	La Trobe University, Mater Medical Research Institute, Menzies School of Health Research, Monash University, University of Adelaide, University of Auckland, University of Melbourne, University of New South Wales, University of Sydney, University of Tasmania, University of Western Australia
NCT06607887	Phase 4	Aug 30, 2024	Minia University, Sohag University
NCT06396078	Phase 4	Jul 18, 2024	Ohio State University
NCT06395610	Phase 1	Mar 28, 2024	Chiesi
NCT06273891	Phase 3	Mar 8, 2024	Eastern Virginia Medical School, Inova Health System
NCT06858618	Phase 2	Aug 16, 2023	Fosun
NCT05995249	Phase 1	Aug 11, 2023	Takeda
NCT05675293	Early Phase 1 (Phase 1)	Jan 15, 2023	October 6 University
NCT05797753	Phase 1	Feb 18, 2022	Sanofi
NCT04714554	Phase 1	Jan 6, 2021	Myovant Sciences GmbH
NCT04682691	Early Phase 1 (Phase 1)	Jan 1, 2021	Cairo University
NCT04665089	N/A	Jan 1, 2021	Tunis University
NCT03966066	N/A	Aug 31, 2019	Capital Medical University
NCT04066231	N/A	Aug 26, 2019	Katholieke Universiteit Leuven
NCT03779360	N/A	Oct 12, 2018	Leiden University, Maruho Co., Ltd.
NCT03593252	N/A	Sep 1, 2018	McMaster University

Showing 20 of 86 trials

Page 1 / 5

Organizations

Research & Development (102)

Organization	Org type	Trials	As lead sponsor	Phases	Earliest year
Katholieke Universiteit Leuven	Academic/Hospital	5	5	2	2012
Boehringer Ingelheim	For profit	3	3	1	1999
Cairo University	Academic/Hospital	3	3	2	2018
Pfizer	For profit	3	3	2	2003
Baqiyatallah Medical Sciences University	Academic/Hospital	2	2	1	2006
Indiana University	Academic/Hospital	2	2	2	2006
Johnson and Johnson	For profit	2	2	1	2011
Leiden University	Academic/Hospital	2	2	2	2018
Maruho Co., Ltd.	For profit	2	0	2	2018
Mayo Clinic	Academic/Hospital	2	2	2	2010
National Institute of Mental Health (NIMH)	Government	2	0	2	2001
Tel Aviv University	Academic/Hospital	2	2	1	2014
University of Melbourne	Academic/Hospital	2	2	1	2025
University of Michigan	Academic/Hospital	2	2	1	1999
AIO-Studien-gGmbH	For profit	1	1	1	2011
Assiut University	Academic/Hospital	1	1	1	2017
AstraZeneca	For profit	1	1	1	2025
Aventis	For profit	1	0	1	1999
Bausch & Lomb	For profit	1	0	1	2011
Bayer	For profit	1	0	1	2011

102 organizations

Page 1 / 6

Marketing (100)

Organization	Org type	Relationship	Date
ACP Nimble	For profit	MKTG	Oct 17, 1990
AH Robins	For profit	MKTG	—
Abbott	For profit	SYN	Jan 4, 1988
Abbott	For profit	MKTG	Nov 29, 1979
Abbott	For profit	NDA2	Nov 29, 1979
Abraxis	For profit	MKTG	—
Akorn, Inc.	For profit	MKTG	Jul 18, 1996
Alembic	For profit	MKTG	Aug 24, 2023
Alkem Labs Ltd	For profit	MKTG	Jul 13, 2022
Alpharma	For profit	MKTG	Aug 11, 1981
Alta Pharma	For profit	MKTG	Jun 15, 1988
Altana	For profit	MKTG	Aug 23, 1991
American Home Products	For profit	MKTG	—
Amneal Pharmaceuticals	For profit	SYN	Nov 1, 2019
Amneal Pharmaceuticals	For profit	MKTG	Mar 9, 2018
Ani Pharmaceuticals	For profit	SYN	Sep 8, 1972
Ani Pharmaceuticals	For profit	MKTG	Sep 8, 1972
Arbor Pharmaceuticals	For profit	NDA2	Aug 6, 1970
Arbor Pharmaceuticals	For profit	SYN	Jun 24, 1964
Arbor Pharmaceuticals	For profit	MKTG	Jun 24, 1964
Athenex, Inc.	For profit	MKTG	—
Aurobindo Pharma	For profit	MKTG	Sep 14, 1988
Azurity	For profit	MKTG	Apr 2, 1965
Azurity	For profit	NDA2	Apr 2, 1965
Barr Laboratories	For profit	MKTG	Apr 28, 1980
Bausch & Lomb	For profit	MKTG	Jan 27, 1994
Bausch Health Companies	For profit	MKTG	Oct 26, 1984
Bausch Health Companies	For profit	SYN	Jan 10, 1985
Bausch Health Companies	For profit	NDA2	Oct 26, 1984
Baxalta	For profit	MKTG	May 9, 1989
Baxter	For profit	MKTG	May 9, 1989
Biofrontera Bioscience GmbH	For profit	NDA2	Nov 27, 2000
Bristol-Myers	For profit	MKTG	Dec 5, 1974
Bristol-Myers Squibb	For profit	MKTG	Oct 23, 2019
Cadila Healthcare	For profit	MKTG	Jun 28, 2021
Cosette	For profit	MKTG	Oct 17, 1990
Cutanea Life Sciences, Inc.	For profit	MKTG	Nov 27, 2000
Dow Pharmaceutical Sciences	For profit	NDA2	Jan 10, 1985
Dow Pharmaceutical Sciences	For profit	MKTG	Jan 24, 1985
Dr. Reddy's Laboratories	For profit	MKTG	Jan 26, 1981
Dr. Reddy's Laboratories	For profit	NDA2	Jan 26, 1981
Eli Lilly	For profit	NDA	Jun 29, 1964
Eli Lilly	For profit	SYN	Apr 13, 1967
Eli Lilly	For profit	MKTG	Jan 3, 1975
Elkins Sinn	For profit	MKTG	Mar 28, 1985
Encube Ethicals Pvt. Ltd.	For profit	MKTG	Mar 29, 2004
Exela Pharma Sciences, LLC.	For profit	MKTG	Sep 17, 2020
Fougera	For profit	MKTG	Jul 3, 1985
G & W Laboratories Inc.	For profit	MKTG	Oct 17, 1990
Hi Tech Pharmaceuticals	For profit	MKTG	Oct 22, 1996
Hospira	For profit	NDA2	Jun 25, 1964
Hospira	For profit	MKTG	Oct 31, 1986
Johnson and Johnson	For profit	NDA2	Feb 15, 1985
Lederle	For profit	MKTG	—
Life Labs	For profit	MKTG	Dec 17, 1982
Lyne Laboratories	For profit	MKTG	Sep 18, 2015
Mayne Pharma	For profit	NDA2	Jan 26, 1981
Merz	For profit	MKTG	Jul 11, 1985
Micro Labs Ltd India	For profit	MKTG	Feb 5, 1988
Mylan	For profit	SYN	Oct 21, 1987
Mylan	For profit	MKTG	Jan 16, 1973
Mylan	For profit	SYN	Feb 5, 1988
Mylan	For profit	NDA2	Oct 21, 1987
Naska Pharmacal	For profit	MKTG	—
Nexus Pharmaceuticals	For profit	MKTG	Feb 14, 2022
Nexus Pharmaceuticals	For profit	SYN	Feb 14, 2022
Padagis Us	For profit	MKTG	Sep 26, 1983
Paddock Laboratories	For profit	NDA2	—
Par Pharmaceuticals	For profit	MKTG	Oct 23, 2019
Parke-Davis	For profit	MKTG	Aug 24, 1977
Perrigo	For profit	MKTG	Jan 29, 1993
Perrigo	For profit	SYN	Sep 26, 1983
Perrigo	For profit	SYN	Jan 11, 1991
Pfizer	For profit	MKTG	—
Pharmaceutical Associates	For profit	MKTG	Jul 19, 2017
Pharmacia & Upjohn	For profit	MKTG	—
Pharmaderm	For profit	MKTG	—
Pharmafair	For profit	MKTG	Jul 25, 1985
Puracap Pharmaceutical	For profit	MKTG	—
Renaissance Pharma	For profit	MKTG	Feb 14, 1997
SENTISS	For profit	MKTG	Jul 18, 1996
Saptalis Pharmaceuticals	For profit	MKTG	Feb 5, 1988
Solvay	For profit	MKTG	—
Squibb	For profit	NDA2	Jun 3, 1980
Squibb	For profit	MKTG	Mar 9, 1983
Syosset	For profit	MKTG	Jul 3, 1985
Taro Pharmaceuticals	For profit	MKTG	Nov 18, 1982
Teligent Pharmaceuticals	For profit	SYN	Jul 19, 2017
Teligent Pharmaceuticals	For profit	MKTG	Jul 19, 2017
Teva	For profit	SYN	Feb 11, 2021
Teva	For profit	SYN	Jul 30, 1993
Teva	For profit	MKTG	Jul 30, 1993
Tolmar Inc.	For profit	MKTG	Mar 29, 2004
Torrent Pharmaceuticals Limited	For profit	MKTG	Jul 6, 2020
Warner Chilcott	For profit	MKTG	May 22, 1981
Warner Lambert	For profit	MKTG	Aug 24, 1977
Watson Pharmaceuticals	For profit	MKTG	Jun 14, 1979
Wockhardt	For profit	MKTG	Oct 23, 1987
Xttrium Laboratories	For profit	MKTG	Oct 23, 1987
Zydus Discovery DMCC	For profit	MKTG	Mar 7, 2023