magnesium trisilicate

Small moleculeapproved

Approved

Dec 9, 1983

Talcum powder is made from talc, a mineral made up mainly of the elements magnesium, silicon, and oxygen. As a powder, it absorbs moisture well and helps cut down on friction, making it useful for keeping skin dry and helping to prevent rashes. It is widely used in cosmetic products such as baby powder and adult body and facial powders, as well as in a number of other consumer products. The therapeutic action of talc instilled into the pleural cavity is believed to result from induction of an inflammatory reaction. This reaction promotes adherence of the visceral and parietal pleura, obliterating the pleural space and preventing reaccumulation of pleural fluid. Sterile Talc Powder, administered intrapleurally via chest tube, is indicated as a sclerosing agent to decrease the recurrence of malignant pleural effusions in symptomatic patients. The most often reported adverse experiences to intrapleurally-administered talc were fever and pain. — NCATS

Clinical trial activity

2 trials · 2 clinical orgs · 5 marketing orgs

Phase 1
0
Phase 2
0
Phase 3
1
Phase 4
1

Earliest trial started Jul 31, 2016 (NCT03516188)

Timeline

1980s

  1. Dec 9, 1983

    Sanofi — Earliest FDA Approval

  2. Dec 9, 1983

    Sanofi-Aventis — NDA Secondary Org

  3. Dec 9, 1983

    Sanofi — NDA Secondary Org

  4. Dec 9, 1983

    Sanofi — NDA Organization

  5. Sep 4, 1987

    Guardian Drug — Marketing Organization

  6. Jun 28, 1989

    Novartis — Marketing Organization

2010s

  1. Jan 1, 2016

    Earliest Phase 2 Sponsor(trial)

Indications

Mechanism of action

  • Unspecified targetOTHER

    Neutralises acid

  • Unspecified targetBuffer

    buffer

Combination products

Approval history

  • approvedDec 9, 1983

Chemistry & pharmacology

Loading structure…

SMILES

[O--].[O--].[O--].[Mg++].[Si+4]
Mol. weight
100.3887 g/mol
Chirality
Achiral Molecule
Inorganic
Yes
Polymer
No
Delivery
Oral
Availability
Discontinued

Oral

Yes

Parenteral

No

Topical

No

Sources

Also known as

  • magnesium mesotrisilicate
  • magnesium silicate
  • magnesium silicate
  • magnesium silicate
  • magnesium silicate
  • magnesium trisilicate
  • magnesium trisilicate
  • magnesium trisilicate
  • magnesium trisilicate
  • magnesium trisilicate
  • magnesium trisilicate
  • magnesium trisilicate
  • magnesium trisilicate hexahydrate (mg4(h2si6o17))
  • magnesium trisilicate hexahydrate ((mg9h14(si3o10)4))
  • magnesium trisilicate hydrate
  • magnesium trisilicate (mg2(h4si3o10))
  • magnesium trisilicate tetrahydrate (mg4(h6si6o19))
  • mag trisil co
  • sepiolite
  • trimax
  • trimax
  • trisilicalm

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT06040190Phase 4Nov 1, 2023Federal University of Minas Gerais
NCT03516188Phase 2/Phase 3 (Phase 3)Jul 31, 2016University of Science Malaysia
Showing 2 of 2 trials
Page 1 / 1

Organizations

Research & Development (2)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Federal University of Minas GeraisAcademic/Hospital1112023
University of Science MalaysiaAcademic/Hospital1112016
2 organizations
Page 1 / 1

Marketing (6)

OrganizationOrg typeRelationshipDate
Guardian DrugFor profitMKTGSep 4, 1987
NovartisFor profitMKTGJun 28, 1989
PENNEXFor profitMKTG
SanofiFor profitNDA2Dec 9, 1983
SanofiFor profitNDADec 9, 1983
Sanofi-AventisFor profitNDA2Dec 9, 1983