domperidone
Small moleculeexperimental
Domperidone, sold under the brand name Motilium among others, is a dopamine antagonist medication which is used to treat nausea and vomiting and certain gastrointestinal problems like gastroparesis. It raises the level of prolactin in the human body. It may be taken by mouth or rectally. — Wikipedia
Clinical trial activity
59 trials · 70 clinical orgs · 0 marketing orgs
Phase 1
7
Phase 2
20
Phase 3
12
Phase 4
11
Earliest trial started Aug 1, 2000 (NCT00006077)
Timeline
Indications
Approved for
Studied for
- Air Travel · Phase 2/Phase 3
- Breast Feeding · Phase 2
- Breast Milk Expression · Phase 2/Phase 3
- Colonoscopy · Phase 4
- Diabetes Mellitus · Phase 4
- Diabetes Mellitus, Type 1 · Phase 3
- Drugs, Investigational · Phase 4
- Dyspepsia · Phase 4
- Edema · Phase 2
- Emotions · Phase 4
- Esophagitis · Phase 3
- Feeding and Eating Disorders · Phase 4
- Gastroenteritis · Phase 3
- Gastroesophageal Reflux · Phase 4
- Gastroparesis · Phase 3
- Healthy Volunteers · Phase 1
- Heartburn · Phase 3
- Heart Diseases · Phase 4
- Hypotension, Orthostatic · Phase 1
- Infant, Premature, Diseases · Phase 2
- Lactation Disorders · Phase 4
- Multiple Sclerosis, Chronic Progressive · Phase 2
- Multiple Sclerosis, Relapsing-Remitting · Phase 2
- Multiple System Atrophy · Phase 1
- Nausea · Phase 3
- Parkinson Disease · Phase 3
- Premature Birth · Phase 4
- Scleroderma, Systemic · Phase 3
- Stomach Diseases · Phase 4
- Vomiting · Phase 3
Mechanism of action
- Dopamine D2 receptorANTAGONIST
DRD2 antagonist
Chemistry & pharmacology
Loading structure…
SMILES
O=c1[nH]c2ccccc2n1CCCN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1- Mol. weight
- 425.92 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaDomperidone ↗
- ChEMBLCHEMBL219916 ↗
Also known as
- 1-(3-(4-(5-chloro-2-oxo-2,3-dihydrobenzo[d]imidazol-1-yl)piperidin-1-yl)propyl)-1h-benzo[d]imidazol-2(3h)-one
- 1-(3-(4-(5-chloro-2-oxo-2,3-dihydrobenzo[d]imidazol-1-yl)piperidin-1-yl)propyl)-1h-benzo[d]imidazol-2(3h)-one
- 5-chloro-1-(1-(3-(2-oxo-1-benzimidazolinyl)propyl)-4-piperidyl)-2-benzimidazolinone
- 5-chloro-1-(1-(3-(2-oxo-1-benzimidazolinyl)propyl)-4-piperidyl)-2-benzimidazolinone
- 5-chloro-1-(1-(3-(2-oxo-2,3-dihydrobenzo[d]imidazol-1-yl)propyl)piperidin-4-yl)-1h-benzo[d]imidazol-2(3h)-one
- 5-chloro-1-(1-(3-(2-oxo-2,3-dihydrobenzo[d]imidazol-1-yl)propyl)piperidin-4-yl)-1h-benzo[d]imidazol-2(3h)-one
- 5-chloro-1-{1-[3-(2-oxo-2,3-dihydro-benzoimidazol-1-yl)-propyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one
- 5-chloro-1-{1-[3-(2-oxo-2,3-dihydro-benzoimidazol-1-yl)-propyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one
- domilium
- domperidona
- domperidona
- domperidone
- domperidone
- domperidone
- domperidone
- domperidone
- domperidone
- domperidone
- domperidone
- domperidone betacyclodextrin
- domperidone betadex
- domperidone betadex
- domperidone betadex
- domperidone betadex
- domperidone betadex
- domperidone betadex
- domperidone maleate
- domperidone maleate
- domperidone maleate
- domperidonum
- domperidonum
- dromperidone
- evoxin
- motilium
- motilium
- motilium
- motilium 10
- motilium instants
- peridon
- r-33812
- r-33812
- vivadone
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06695962 | Phase 3 | Mar 1, 2025 | Rouen Normandy University |
| NCT06590805 | N/A | Sep 1, 2024 | Kafrelsheikh University |
| NCT06171087 | Phase 4 | Aug 1, 2023 | German Institute of Human Nutrition |
| NCT05596006 | Phase 2 | Dec 31, 2022 | Gadjah Mada University |
| NCT05570292 | Phase 3 | Oct 10, 2022 | Ain Shams University |
| NCT04802785 | Phase 2/Phase 3 (Phase 3) | Jun 30, 2021 | lurye Clinic |
| NCT04583111 | Phase 4 | Mar 1, 2020 | Jiao Tong University |
| NCT04104867 | N/A | Sep 16, 2019 | Mahidol University |
| NCT05030116 | Phase 4 | Jun 26, 2019 | Jiao Tong University |
| NCT03617016 | Phase 4 | Aug 10, 2018 | Johnson and Johnson |
| NCT03355170 | Phase 4 | Mar 1, 2018 | Ege University, NeuTec Pharma |
| NCT03806062 | Phase 4 | Jan 2, 2018 | Cairo University |
| NCT03662113 | N/A | Nov 1, 2017 | Fudan University |
| NCT02816853 | Phase 1 | May 1, 2016 | Johnson and Johnson |
| NCT02699385 | Phase 3 | Dec 7, 2015 | Johnson and Johnson |
| NCT02980250 | Phase 4 | Nov 1, 2015 | Guangdong Provincial Maternal and Child Health Hospital, Guangzhou Panyu Central Hospital, Maternal and Child Health Hospital of Foshan, Shen-Zhen City Maternity and Child Healthcare Hospital, Southern Medical University |
| NCT02567175 | N/A | Oct 1, 2015 | Children's Hospital of Philadelphia, University of Pennsylvania |
| NCT02493049 | Phase 2 | Aug 1, 2015 | Alberta Innovates Health Solutions, University of Calgary |
| NCT02494687 | N/A | Jul 8, 2015 | Eastern Regional Medical Center |
| NCT02757534 | Phase 2 | May 1, 2015 | University of Iowa |
Showing 20 of 59 trials
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Organizations
Research & Development (70)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Johnson and Johnson | For profit | 4 | 4 | 3 | 2012 |
| Jiao Tong University | Academic/Hospital | 3 | 2 | 2 | 2010 |
| Alberta Innovates Health Solutions | Academic/Hospital | 2 | 0 | 1 | 2015 |
| Dalhousie University | Academic/Hospital | 2 | 1 | 2 | 2003 |
| NeuTec Pharma | For profit | 2 | 2 | 1 | 2014 |
| University of Calgary | Academic/Hospital | 2 | 2 | 1 | 2015 |
| University of Iowa | Academic/Hospital | 2 | 2 | 2 | 2012 |
| University of Toronto | Academic/Hospital | 2 | 2 | 1 | 2006 |
| Yale University | Academic/Hospital | 2 | 2 | 2 | 2008 |
| Agenzia Italiana del Farmaco | Government | 1 | 0 | 1 | 2011 |
| Ain Shams University | Academic/Hospital | 1 | 1 | 1 | 2022 |
| Allegiance Health | Academic/Hospital | 1 | 1 | 1 | 2010 |
| Allegiance Health Gastroenterology | Academic/Hospital | 1 | 0 | 1 | 2010 |
| Ascension Health | Academic/Hospital | 1 | 1 | 1 | 2008 |
| Belarusian Medical Academy of Post-Graduate Education | Academic/Hospital | 1 | 1 | 1 | 2013 |
| Boehringer Ingelheim | For profit | 1 | 1 | 1 | 2011 |
| Cairo University | Academic/Hospital | 1 | 1 | 1 | 2018 |
| Canadian Nurses Foundation (CNF) | Academic/Hospital | 1 | 0 | 1 | 2003 |
| Carle Foundation Hospital | Academic/Hospital | 1 | 0 | 1 | 2008 |
| Carle Health Care Incorporated | Academic/Hospital | 1 | 0 | 1 | 2008 |
70 organizations
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