netazepide
Small moleculeexperimental
Clinical trial activity
13 trials · 9 clinical orgs · 0 marketing orgs
Phase 1
8
Phase 2
5
Phase 3
0
Phase 4
0
Earliest trial started May 1, 1996 (NCT01538784)
Timeline
Indications
Mechanism of action
- Cholecystokinin B receptorANTAGONIST
CCKBR antagonist
Chemistry & pharmacology
Loading structure…
SMILES
CNc1cccc(NC(=O)N[C@@H]2N=C(c3ccccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1- Mol. weight
- 498.59 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL324547 ↗
Also known as
- n-(1-(tert-butylcarbonylmethyl)-2,3-dihydro-2-oxo-5-(2-pyridyl)-1h-1,4-benzodiazepin-3-yl)-n'-(3-(methylamino)phenyl)urea
- netazepide
- netazepide
- netazepide
- netazepide
- netazepide
- yf476
- yf476
- yf476
- yf 476
- yf-476
- yf-476
- yf-476
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT02597712 | Phase 2 | Jun 1, 2013 | Columbia University, Hammersmith Medicines Research, University of Cambridge |
| NCT01444014 | Phase 2 | Jun 1, 2011 | Hammersmith Medicines Research, Norwegian University of Science and Technology |
| NCT02454075 | Phase 2 | Apr 1, 2011 | Hammersmith Medicines Research, National Institutes of Health (NIH) |
| NCT01339169 | Phase 2 | Jan 1, 2011 | Hammersmith Medicines Research, Royal Liverpool & Broadgreen University Hospitals NHS Truts |
| NCT01298999 | Phase 2 | Jun 1, 2010 | Columbia University, Hammersmith Medicines Research, National Institute for Health Research, United Kingdom |
| NCT02620696 | Phase 1 | Nov 1, 2009 | Hammersmith Medicines Research |
| NCT01699113 | Phase 1 | Aug 1, 2006 | Hammersmith Medicines Research |
| NCT01601405 | Phase 1 | Oct 1, 2001 | Hammersmith Medicines Research, James Black Foundation |
| NCT01601418 | Phase 1 | Oct 1, 2001 | Hammersmith Medicines Research, James Black Foundation |
| NCT01597674 | Phase 1 | Apr 1, 1997 | Ferring, Hammersmith Medicines Research |
| NCT01599858 | Phase 1 | Aug 1, 1996 | Ferring, Hammersmith Medicines Research |
| NCT01538797 | Phase 1 | Jul 1, 1996 | Ferring, Hammersmith Medicines Research |
| NCT01538784 | Phase 1 | May 1, 1996 | Ferring, Hammersmith Medicines Research |
Showing 13 of 13 trials
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Organizations
Research & Development (9)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Hammersmith Medicines Research | For profit | 13 | 12 | 2 | 1996 |
| Ferring | For profit | 4 | 0 | 1 | 1996 |
| Columbia University | Academic/Hospital | 2 | 1 | 1 | 2010 |
| James Black Foundation | Academic/Hospital | 2 | 0 | 1 | 2001 |
| National Institute for Health Research, United Kingdom | Government | 1 | 0 | 1 | 2010 |
| National Institutes of Health (NIH) | Government | 1 | 0 | 1 | 2011 |
| Norwegian University of Science and Technology | Academic/Hospital | 1 | 0 | 1 | 2011 |
| Royal Liverpool & Broadgreen University Hospitals NHS Truts | Academic/Hospital | 1 | 0 | 1 | 2011 |
| University of Cambridge | Academic/Hospital | 1 | 0 | 1 | 2013 |
9 organizations
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