magrolimab
mAbexperimental
Clinical trial activity
27 trials · 19 clinical orgs · 0 marketing orgs
Phase 1
12
Phase 2
17
Phase 3
3
Phase 4
0
Earliest trial started May 31, 2020 (NCT04403308)
Timeline
Indications
Studied for
- Brain Neoplasms · Phase 1
- Breast Neoplasms · Phase 1
- Carcinoma, Transitional Cell · Phase 1
- Colorectal Neoplasms · Phase 2
- Hodgkin Disease · Phase 2
- Leukemia, Myeloid, Acute · Phase 3
- Lymphoma · Phase 1
- Lymphoma, B-Cell · Phase 2
- Lymphoma, B-Cell, Marginal Zone · Phase 1
- Lymphoma, Follicular · Phase 1
- Lymphoma, Large-Cell, Immunoblastic · Phase 2
- Lymphoma, Mantle-Cell · Phase 1
- Multiple Myeloma · Phase 2
- Mycosis Fungoides · Phase 1/Phase 2
- Myelodysplastic Syndromes · Phase 3
- Neoplasms · Phase 2
- Neuroblastoma · Phase 1
- Osteosarcoma · Phase 1
- Pancreatic Neoplasms · Phase 1
- Prostatic Neoplasms, Castration-Resistant · Phase 1
- Sezary Syndrome · Phase 1/Phase 2
- Squamous Cell Carcinoma of Head and Neck · Phase 2
- Triple Negative Breast Neoplasms · Phase 2
Mechanism of action
- Leukocyte surface antigen CD47INHIBITOR
Leukocyte surface antigen CD47 inhibitor
Chemistry & pharmacology
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
- Multi-specific
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL4297985 ↗
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT05367401 | Phase 1/Phase 2 (Phase 2) | Dec 20, 2024 | Novartis |
| NCT05807126 | Phase 1 | Mar 5, 2024 | National Cancer Institute (NCI), University of Pittsburgh |
| NCT05829434 | Phase 2 | Jan 31, 2024 | Gilead Sciences, University of Leipzig |
| NCT05823480 | Phase 1 | Dec 9, 2023 | City of Hope National Medical Center, National Cancer Institute (NCI) |
| NCT06046482 | Phase 2 | Nov 28, 2023 | Gilead Sciences, University of Texas at Houston |
| NCT05929716 | Phase 2 | Sep 30, 2023 | University of Texas at Houston |
| NCT05835011 | Phase 2 | Jul 14, 2023 | Astex Pharmaceuticals, Inc. |
| NCT05738161 | Phase 1 | Jun 21, 2023 | Swiss National Science Foundation, University of Bern |
| NCT05330429 | Phase 2 | Jul 8, 2022 | Gilead Sciences |
| NCT05169944 | Phase 1 | Apr 22, 2022 | Gilead Sciences, Harvard University, University of California, San Francisco, University of Utah |
| NCT05079230 | Phase 3 | Dec 31, 2021 | Gilead Sciences |
| NCT04788043 | Phase 2 | Nov 30, 2021 | Merck, Stanford University |
| NCT04892446 | Phase 2 | Nov 30, 2021 | Gilead Sciences |
| NCT04958785 | Phase 2 | Oct 31, 2021 | Gilead Sciences |
| NCT04827576 | Phase 2 | Oct 1, 2021 | Gilead Sciences |
| NCT06540261 | Phase 1 | Sep 23, 2021 | Ono Pharmaceuticals |
| NCT04854499 | Phase 2 | Sep 7, 2021 | Gilead Sciences |
| NCT06532344 | Phase 1 | Jul 30, 2021 | Ono Pharmaceuticals |
| NCT04778397 | Phase 3 | Jul 1, 2021 | Gilead Sciences |
| NCT04778410 | Phase 2 | Jun 28, 2021 | Gilead Sciences |
Showing 20 of 27 trials
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Organizations
Research & Development (19)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Gilead Sciences | For profit | 13 | 9 | 4 | 2020 |
| National Cancer Institute (NCI) | Government | 5 | 4 | 2 | 2021 |
| Ono Pharmaceuticals | For profit | 3 | 3 | 1 | 2020 |
| University of Texas at Houston | Academic/Hospital | 3 | 3 | 1 | 2020 |
| City of Hope National Medical Center | Academic/Hospital | 2 | 1 | 2 | 2021 |
| Astex Pharmaceuticals, Inc. | For profit | 1 | 1 | 1 | 2023 |
| Cancer Immunotherapy Trials Network | Academic/Hospital | 1 | 0 | 1 | 2021 |
| Forty Seven, Inc. | For profit | 1 | 1 | 1 | 2020 |
| Genentech | For profit | 1 | 0 | 1 | 2020 |
| Harvard University | Academic/Hospital | 1 | 0 | 1 | 2022 |
| Merck | For profit | 1 | 0 | 1 | 2021 |
| Novartis | For profit | 1 | 1 | 1 | 2024 |
| Stanford University | Academic/Hospital | 1 | 1 | 1 | 2021 |
| Swiss National Science Foundation | Government | 1 | 0 | 1 | 2023 |
| University of Bern | Academic/Hospital | 1 | 1 | 1 | 2023 |
| University of California, San Francisco | Academic/Hospital | 1 | 1 | 1 | 2022 |
| University of Leipzig | Academic/Hospital | 1 | 1 | 1 | 2024 |
| University of Pittsburgh | Academic/Hospital | 1 | 0 | 1 | 2024 |
| University of Utah | Academic/Hospital | 1 | 0 | 1 | 2022 |
19 organizations
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