Iopofosine
Small moleculeexperimental
Clinical trial activity
5 trials · 5 clinical orgs · 0 marketing orgs
Phase 1
4
Phase 2
1
Phase 3
0
Phase 4
0
Earliest trial started Dec 1, 2016 (NCT02952508)
Timeline
Indications
Studied for
- Brain Neoplasms · Phase 1
- Diffuse Intrinsic Pontine Glioma · Phase 1
- Glioma · Phase 1
- Head and Neck Neoplasms · Phase 1
- Leukemia, Lymphocytic, Chronic, B-Cell · Phase 2
- Lymphoma · Phase 2
- Lymphoma, B-Cell, Marginal Zone · Phase 2
- Lymphoma, Large B-Cell, Diffuse · Phase 2
- Lymphoma, Mantle-Cell · Phase 2
- Multiple Myeloma · Phase 2
- Neoplasms · Phase 1
- Neuroblastoma · Phase 1
- Osteosarcoma · Phase 1
- Rhabdomyosarcoma · Phase 1
- Sarcoma, Ewing · Phase 1
- Waldenstrom Macroglobulinemia · Phase 2
Mechanism of action
- Unspecified targetRadiodepletion
radiodepletion
Chemistry & pharmacology
Loading structure…
SMILES
C[N+](C)(C)CCOP(=O)([O-])OCCCCCCCCCCCCCCCCCCc1ccc(I)cc1- Mol. weight
- 637.62 g/mol
- Lipinski Ro5
- 2 violation(s)
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
- Payload
- 131-iodine
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL4297495 ↗
- ChEMBLCHEMBL208375 ↗
Also known as
- clr 131
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07311993 | Phase 1 | Dec 5, 2025 | Cellectar, Inc |
| NCT05610891 | Phase 1 | Nov 30, 2022 | Balance Therapeutics, Cellectar, Inc, National Cancer Institute (NCI) |
| NCT04105543 | Phase 1 | Oct 31, 2019 | Cellectar, Inc, National Institute of Dental and Craniofacial Research (NIDCR), University of Wisconsin |
| NCT03478462 | Phase 1 | Jul 31, 2018 | Cellectar, Inc, University of Wisconsin |
| NCT02952508 | Phase 2 | Dec 1, 2016 | Cellectar, Inc |
Showing 5 of 5 trials
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Organizations
Research & Development (5)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Cellectar, Inc | For profit | 5 | 4 | 2 | 2016 |
| University of Wisconsin | Academic/Hospital | 2 | 1 | 1 | 2018 |
| Balance Therapeutics | For profit | 1 | 0 | 1 | 2022 |
| National Cancer Institute (NCI) | Government | 1 | 0 | 1 | 2022 |
| National Institute of Dental and Craniofacial Research (NIDCR) | Government | 1 | 0 | 1 | 2019 |
5 organizations
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