cudc-907
Small moleculeexperimental
Clinical trial activity
7 trials · 8 clinical orgs · 0 marketing orgs
Phase 1
4
Phase 2
3
Phase 3
0
Phase 4
0
Earliest trial started Dec 1, 2012 (NCT01742988)
Timeline
Indications
Studied for
- Astrocytoma · Early Phase 1
- Brain Neoplasms · Phase 1
- Carcinoma · Phase 1
- Diffuse Intrinsic Pontine Glioma · Early Phase 1
- Glioblastoma · Early Phase 1
- Glioma · Early Phase 1
- Lymphoma · Phase 1
- Lymphoma, B-Cell · Phase 1
- Lymphoma, Large B-Cell, Diffuse · Phase 2
- Medulloblastoma · Early Phase 1
- Neoplasms · Phase 1
- Neuroblastoma · Phase 1
- Ovarian Neoplasms · Phase 1
- Pituitary ACTH Hypersecretion · Phase 2
- Thyroid Neoplasms · Phase 2
- Triple Negative Breast Neoplasms · Phase 1
Mechanism of action
- PI3-kinase p110-beta subunitINHIBITOR
PIK3CB inhibitor
Inhibits mainly class I and IIb HDACS (PMID:22693356)
- PI3-kinase p110-alpha subunitINHIBITOR
PIK3CA inhibitor
Inhibits mainly class I and IIb HDACS (PMID:22693356)
- PI3-kinase p110-delta subunitINHIBITOR
PIK3CD inhibitor
Inhibits mainly class I and IIb HDACS (PMID:22693356)
- Histone deacetylaseINHIBITOR
Histone deacetylase inhibitor
Inhibits mainly class I and IIb HDACS (PMID:22693356)
- Histone deacetylase 1 (HDAC1) ↗
- Histone deacetylase 3 (HDAC3) ↗
- Histone deacetylase 6 (HDAC6) ↗
- Histone deacetylase 2 (HDAC2) ↗
- Histone deacetylase 5 (HDAC5) ↗
- Histone deacetylase 7 (HDAC7) ↗
- Histone deacetylase 8 (HDAC8) ↗
- Histone deacetylase 11 (HDAC11) ↗
- Histone deacetylase 4 (HDAC4) ↗
- Histone deacetylase 9 (HDAC9) ↗
- Histone deacetylase 10 (HDAC10) ↗
- Histone deacetylase 8
- Histone deacetylase 10
- Histone deacetylase 2
- Histone deacetylase 3
- Histone deacetylase 4
- Histone deacetylase 6
- Histone deacetylase 9
- Histone deacetylase 11
- Histone deacetylase 5
- Histone deacetylase 7
- Histone deacetylase 1
- Histone deacetylase (HDAC1 and HDAC2)
- Histone deacetylase 1/3/5/8
- Histone deacetylase 1/2/3/6
- Histone deacetylase 1/2/3
- Histone deacetylase 1/8
- Histone deacetylase 1/6
- Class 1 histone deacetylase
- Histone deacetylase 6/3
Chemistry & pharmacology
Loading structure…
SMILES
COc1ccc(-c2nc(N3CCOCC3)c3sc(CN(C)c4ncc(C(=O)NO)cn4)cc3n2)cn1- Mol. weight
- 508.56 g/mol
- Lipinski Ro5
- 2 violation(s)
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL3622533 ↗
- ChEMBLCHEMBL3545052 ↗
Also known as
- cudc-907
- cudc-907
- cudc-907
- cudc-907
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT05971758 | Phase 2 | Jan 31, 2024 | University of California, Los Angeles |
| NCT03893487 | Early Phase 1 (Phase 1) | Jul 31, 2019 | Cannonball Kids' Cancer Foundation, Curis, The Pacific Pediatric Neuro-Oncology Consortium, University of California, San Francisco |
| NCT03002623 | Phase 2 | Dec 16, 2016 | National Cancer Institute (NCI) |
| NCT02909777 | Phase 1 | Oct 1, 2016 | Curis, Harvard University |
| NCT02674750 | Phase 2 | Jan 1, 2016 | Curis |
| NCT02307240 | Phase 1 | Nov 1, 2014 | Curis |
| NCT01742988 | Phase 1 | Dec 1, 2012 | Curis, The Leukemia and Lymphoma Society |
Showing 7 of 7 trials
Page 1 / 1
Organizations
Research & Development (8)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Curis | For profit | 5 | 3 | 2 | 2012 |
| Cannonball Kids' Cancer Foundation | Academic/Hospital | 1 | 0 | 1 | 2019 |
| Harvard University | Academic/Hospital | 1 | 1 | 1 | 2016 |
| National Cancer Institute (NCI) | Government | 1 | 1 | 1 | 2016 |
| The Leukemia and Lymphoma Society | Academic/Hospital | 1 | 0 | 1 | 2012 |
| The Pacific Pediatric Neuro-Oncology Consortium | Academic/Hospital | 1 | 0 | 1 | 2019 |
| University of California, Los Angeles | Academic/Hospital | 1 | 1 | 1 | 2024 |
| University of California, San Francisco | Academic/Hospital | 1 | 1 | 1 | 2019 |
8 organizations
Page 1 / 1