rta 744
Small moleculeexperimental
Clinical trial activity
7 trials · 6 clinical orgs · 0 marketing orgs
Phase 1
5
Phase 2
3
Phase 3
0
Phase 4
0
Earliest trial started Nov 1, 2005 (NCT00526812)
Timeline
Indications
Mechanism of action
- DNA topoisomerase IIINHIBITOR
DNA topoisomerase II inhibitor
Intercalates into DNA and interrupts topoisomerase II activity, resulting in the inhibition of DNA replication and repair, and RNA and protein synthesis
Chemistry & pharmacology
Loading structure…
SMILES
COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](OCc2ccccc2)[C@H](C)O1- Mol. weight
- 633.65 g/mol
- Lipinski Ro5
- 2 violation(s)
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL2110580 ↗
- ChEMBLCHEMBL2103796 ↗
Also known as
- berubicin
- berubicin
- berubicin hcl
- berubicin hcl
- berubicin hydrochloride
- berubicin hydrochloride
- berubicin hydrochloride
- rta 744
- rta 744
- rta 744
- rta-744
- rta-744
- wp744
- wp744
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT05082493 | Phase 1 | Oct 31, 2021 | Worldwide Clinical Trials, WPD Pharmaceuticals Sp. z o.o. |
| NCT04915404 | Phase 1/Phase 2 (Phase 2) | Jul 15, 2021 | Government of Poland, Worldwide Clinical Trials, WPD Pharmaceuticals Sp. z o.o. |
| NCT04762069 | Phase 2 | May 18, 2021 | CNS Pharmaceuticals, Inc., Worldwide Clinical Trials |
| NCT00538343 | Phase 2 | Oct 1, 2007 | Reata Pharmaceuticals, Inc. |
| NCT00527410 | Phase 1 | Oct 1, 2006 | Reata Pharmaceuticals, Inc. |
| NCT00512460 | Phase 1 | Sep 1, 2006 | Reata Pharmaceuticals, Inc., University of Texas at Houston |
| NCT00526812 | Phase 1 | Nov 1, 2005 | Reata Pharmaceuticals, Inc. |
Showing 7 of 7 trials
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Organizations
Research & Development (6)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Reata Pharmaceuticals, Inc. | For profit | 4 | 3 | 2 | 2005 |
| Worldwide Clinical Trials | For profit | 3 | 0 | 2 | 2021 |
| WPD Pharmaceuticals Sp. z o.o. | For profit | 2 | 2 | 2 | 2021 |
| CNS Pharmaceuticals, Inc. | For profit | 1 | 1 | 1 | 2021 |
| Government of Poland | Government | 1 | 0 | 1 | 2021 |
| University of Texas at Houston | Academic/Hospital | 1 | 1 | 1 | 2006 |
6 organizations
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