talotrexin
Small moleculeexperimental
Clinical trial activity
5 trials · 5 clinical orgs · 0 marketing orgs
Phase 1
5
Phase 2
2
Phase 3
0
Phase 4
0
Earliest trial started Mar 1, 2004 (NCT00088023)
Timeline
2000s
- Jan 1, 2004
Earliest Phase 1 Sponsor(trial)
Indications
Approved for
Mechanism of action
- Folate receptor alphaINHIBITOR
FOLR1 inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
Nc1nc(N)c2nc(CNc3ccc(C(=O)N[C@@H](CCCNC(=O)c4ccccc4C(=O)O)C(=O)O)cc3)cnc2n1- Mol. weight
- 573.57 g/mol
- Lipinski Ro5
- 3 violation(s)
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL590985 ↗
- ChEMBLCHEMBL2104985 ↗
Also known as
- n(alpha)-(4-amino-4-deoxypteroyl)-n(delta)-hemiphthaloyl-l-ornithine
- pt523
- pt 523
- pt-523
- pt-523
- pt-523
- pt-523
- talotrexin
- talotrexin
- talotrexin
- talotrexin
- talotrexin ammonium
- talotrexin ammonium
- talotrexin ammonium
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT00112060 | Phase 1/Phase 2 (Phase 2) | Apr 1, 2008 | Spectrum Pharmaceuticals |
| NCT00458744 | Phase 1 | Feb 1, 2007 | Indiana University, National Cancer Institute (NCI), Tata Memorial Hospital |
| NCT00129558 | Phase 1/Phase 2 (Phase 2) | Jul 1, 2005 | Spectrum Pharmaceuticals |
| NCT00098514 | Phase 1 | Oct 1, 2004 | Harvard University, National Cancer Institute (NCI) |
| NCT00088023 | Phase 1 | Mar 1, 2004 | Harvard University, National Cancer Institute (NCI), Spectrum Pharmaceuticals |
Showing 5 of 5 trials
Page 1 / 1
Organizations
Research & Development (5)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| National Cancer Institute (NCI) | Government | 3 | 1 | 1 | 2004 |
| Spectrum Pharmaceuticals | For profit | 3 | 3 | 2 | 2004 |
| Harvard University | Academic/Hospital | 2 | 1 | 1 | 2004 |
| Indiana University | Academic/Hospital | 1 | 0 | 1 | 2007 |
| Tata Memorial Hospital | Academic/Hospital | 1 | 0 | 1 | 2007 |
5 organizations
Page 1 / 1