CDEK
← All drugs Report issue

iodine

Small moleculeapproved

Approved

Jun 1, 1955

Iodine is a chemical element; it has symbol I and atomic number 53. The heaviest of the stable halogens, it exists at standard conditions as a semi-lustrous, non-metallic solid that melts to form a deep violet liquid at 114 °C (237 °F), and boils to a violet gas at 184 °C (363 °F). The element was discovered by the French chemist Bernard Courtois in 1811 and was named two years later by Joseph Louis Gay-Lussac, after the Ancient Greek Ιώδης, meaning 'violet'. — Wikipedia

Clinical trial activity

231 trials · 265 clinical orgs · 5 marketing orgs

Phase 1
20
Phase 2
75
Phase 3
37
Phase 4
61

Earliest trial started Jan 1, 2000 (NCT01717729)

Timeline

1950s

  1. Jun 1, 1955

    Earliest FDA Approval

1980s

  1. Nov 29, 1985

    Becton Dickinson — NDA Secondary Org

  2. Dec 17, 1986

    Alcon — First NDA Organization

  3. Dec 17, 1986

    Nestle — NDA Secondary Org

  4. Dec 17, 1986

    Alcon — NDA Organization

  5. Mar 31, 1989

    Allegiance Health — NDA Secondary Org

  6. Jul 25, 1989

    Clinipad — NDA Secondary Org

2000s

  1. Jan 1, 2000

    Earliest Phase 3 Sponsor(trial)

  2. Jan 1, 2002

    Earliest Phase 2 Sponsor(trial)

2010s

  1. Jan 1, 2014

    Earliest Phase 1 Sponsor(trial)

Indications

Approved for

Studied for

Mechanism of action

  • BacteriaOXIDATIVE ENZYME

    Bacteria oxidative enzyme

Approval history

  • approvedJun 1, 1955

Chemistry & pharmacology

Loading structure…

SMILES

II
Mol. weight
253.81 g/mol
Lipinski Ro5
Pass
Rule of 3
Yes
Chirality
Achiral Molecule
Inorganic
No
Polymer
No
Availability
Over the Counter

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • betadine
  • betadine
  • betadine
  • betadine
  • betadine vc kit
  • betasept
  • codella
  • crospovidone
  • diiodine
  • diiodine
  • e-z prep
  • e-z prep 220
  • e-z scrub
  • e-z scrub 201
  • e-z scrub 241
  • i2
  • i2
  • iocide
  • iodine
  • iodine
  • iodine
  • iodine
  • iodine
  • iodine
  • iodine
  • iodine
  • iodine-povidone complex
  • iodovidone
  • iodum
  • iodum
  • jod
  • jod
  • k30
  • k30
  • k40
  • k40
  • k90
  • k90
  • kollidon 25, 30, 12pf, 17pf, 90f
  • molecular iodine
  • molecular iodine
  • plasdone
  • plasdone
  • polyvidon
  • polyvidone
  • polyvidone
  • polyvidone
  • polyvinylpyrrolidone
  • polyvinylpyrrolidone
  • polyvinylpyrrolidone
  • polyvinylpyrrolidone (k25)
  • polyvinylpyrrolidone [k25, k30, k90]
  • povidone
  • povidone
  • povidone
  • povidone
  • povidone
  • povidone
  • povidone
  • povidone iodine
  • povidone iodine
  • povidone iodine
  • povidone iodine
  • povidone-iodine
  • povidone-iodine
  • povidone-iodine
  • povidone-iodine
  • povidone-iodine
  • povidone-iodine
  • povidone-iodine
  • povidone-iodine
  • povidone-iodine
  • povidone-iodine
  • proviodine
  • vbp-245
  • vinisil
  • vinisil

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT07044726Phase 4Jun 23, 2025University of Louisville
NCT06899672N/AApr 1, 2025Altamash Institute of Dental Medicine
NCT06836271Phase 2Mar 1, 2025Hitit University
NCT06811857N/AJan 31, 2025Shantou University
NCT06667089N/AJan 7, 2025University of Jaén
NCT06744907Phase 4Dec 15, 2024Northeast Ohio Medical University
NCT06463678Phase 2Dec 1, 2024IVIEW Therapeutics Inc.
NCT06601803Phase 4Sep 16, 2024Thomas Jefferson University
NCT06616207Phase 2Sep 13, 2024University of Washington
NCT06207786N/ASep 1, 2024Mayo Clinic
NCT05745467Phase 4Jul 3, 20243M, University of Iowa
NCT06232421Phase 2/Phase 3 (Phase 3)Jun 30, 2024Belarusian State Medical University
NCT06363877Phase 3Jun 3, 2024Loma Linda University
NCT06282510Phase 4Jan 29, 2024RML Specialty Hospital, Rush University
NCT06176976N/ADec 15, 2023Aristotle University of Thessaloniki
NCT06126614Phase 3Nov 30, 2023Hamilton Health Sciences Corporation, McMaster University
NCT06063941N/AOct 10, 2023Ankang City Central Hospital, Government of China, People's Liberation Army of China, Xi'an International Medical Center Hospital
NCT05919888Phase 4Jun 26, 2023Next Science, St. Louis University
NCT05895773Phase 2/Phase 3 (Phase 3)Jun 24, 2023Menoufia University
NCT06339294Phase 1Jun 16, 2023Rawalpindi Medical College, Pakistan
Showing 20 of 231 trials
Page 1 / 12

Organizations

Research & Development (265)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
3MFor profit6232010
Assiut UniversityAcademic/Hospital6652012
University of IowaAcademic/Hospital6622013
Harvard UniversityAcademic/Hospital5332015
Thomas Jefferson UniversityAcademic/Hospital5432010
Ain Shams UniversityAcademic/Hospital4432014
McMaster UniversityAcademic/Hospital4232012
University of British ColumbiaAcademic/Hospital4422009
University of PoitiersAcademic/Hospital4422004
Washington University in St. LouisAcademic/Hospital4222011
Cairo UniversityAcademic/Hospital3322016
IVIEW Therapeutics Inc.For profit3312019
Mashhad University of Medical SciencesAcademic/Hospital3332013
Microdermis CorporationFor profit3022013
MundipharmaFor profit3222014
National University of SingaporeAcademic/Hospital3232014
New York UniversityAcademic/Hospital3232011
Seoul National UniversityAcademic/Hospital3332009
The University of Texas, DallasAcademic/Hospital3222010
University of California, Los AngelesAcademic/Hospital3222002
265 organizations
Page 1 / 14

Marketing (5)

OrganizationOrg typeRelationshipDate
AlconFor profitNDADec 17, 1986
Allegiance HealthAcademic/HospitalNDA2Mar 31, 1989
Becton DickinsonFor profitNDA2Nov 29, 1985
ClinipadFor profitNDA2Jul 25, 1989
NestleFor profitNDA2Dec 17, 1986