gadopenteate dimeglumine

Trade name: magnevist

Small moleculeapprovedImaging agent

Approved

Jun 2, 1988

Gadopentetic acid, sold under the brand name Magnevist, is a gadolinium-based MRI contrast agent. — Wikipedia

Clinical trial activity

38 trials · 27 clinical orgs · 1 marketing orgs

Phase 1

Phase 2

Phase 3

Phase 4

Earliest trial started Apr 1, 1996 (NCT00005790)

Timeline

1980s

Jun 2, 1988
Bayer — Earliest FDA Approval
Jun 2, 1988
Bayer — NDA Secondary Org
Jun 2, 1988
Bayer — NDA Organization

1990s

Jan 1, 1998
Earliest Phase 2 Sponsor(trial)

2000s

Jan 1, 2003
Bayer — Earliest Phase 3 Sponsor(trial)
Jan 1, 2004
Bayer — Earliest Phase 1 Sponsor(trial)

Indications

Approved for

Diagnostic Imaging (approved 1988)

Studied for

Mechanism of action

Unspecified targetOTHER
Diagnostic agent
contrast mediumRadiopaque
contrast medium radiopaque

Approval history

approvedPriority reviewJun 2, 1988

Chemistry & pharmacology

Mol. weight: 742.79 g/mol
Chirality: Single Stereoisomer
Inorganic: No
Polymer: No
Delivery: Parenteral
Availability: Discontinued

Oral

Parenteral

Yes

Topical

Black box warning

Sources

WikipediaGadopentetic acid ↗
ChEMBLCHEMBL1200431 ↗

Also known as

diethylenetriaminepentaacetic acid dimeglumine salt gadolinium chelate
diethylenetriaminepentaacetic acid dimeglumine salt gadolinium chelate
dimeglumine-gadolinium-dtpa
dimeglumine-gadolinium-dtpa
gadopentate dimeglumine
gadopentetate dimeglumine
gadopentetate dimeglumine
gadopentetate dimeglumine
gadopentetate dimeglumine
gadopentetate dimeglumine
gadopentetate dimeglumine
gadopentetate dimeglumine
gadopentetic acid
gadopentetic acid
gadopentetic acid
gadopentetic acid dimeglumine salt
gadopentetic acid dimeglumine salt
gd-dtpa
gd-dtpa
gd-dtpa
magnevist
magnevist
magnevist
magnevist
magnevist
magnevist
magnevist
magnevist
meglumine gadopentetate
meglumine gadopentetate
sh l 451 a
sh l 451 a
sh-l 451 a
sh-l 451 a

Clinical trials

NCT ID	Phase	Start date	Sponsor(s)
NCT03057561	N/A	Oct 1, 2016	Guerbet, Methodist Cancer Center, Houston, Texas, The Methodist Hospital System
NCT02371798	N/A	Feb 1, 2015	Emory University
NCT02156739	N/A	Oct 1, 2014	University of Texas at Houston
NCT02722525	N/A	Oct 1, 2014	Ohio State University
NCT02057874	N/A	Feb 1, 2014	National Cancer Institute (NCI), Vanderbilt University
NCT02175069	Phase 4	Dec 1, 2013	Paracelsus Medical University
NCT01892540	N/A	May 1, 2013	Case Western Reserve University, National Cancer Institute (NCI)
NCT01956409	Phase 4	Sep 1, 2012	National Taiwan University
NCT01996527	Early Phase 1 (Phase 1)	May 1, 2012	National Cancer Institute (NCI), Vanderbilt University
NCT02080312	N/A	Jan 1, 2012	American Society of Head and Neck Radiology, University of California, San Diego
NCT02967380	N/A	Dec 14, 2011	National Cancer Institute (NCI), University of Southern California
NCT01287026	Phase 1	Jan 13, 2011	National Heart, Lung, and Blood Institute (NHLBI)
NCT01211873	Phase 3	Sep 1, 2010	Guerbet, University of Washington
NCT01050829	Phase 3	Jan 1, 2010	Bayer
NCT00937391	Phase 3	Jan 1, 2010	Bayer
NCT01416740	N/A	Dec 1, 2009	Pennsylvania State University
NCT01260636	Phase 3	Sep 1, 2009	Bracco
NCT00677963	N/A	Jun 1, 2009	Maastricht University
NCT00486473	Phase 3	Jul 1, 2007	Bracco
NCT00408083	Phase 3	Dec 1, 2006	Bracco

Showing 20 of 38 trials

Page 1 / 2

Organizations

Research & Development (27)

Organization	Org type	Trials	As lead sponsor	Phases	Earliest year
Bayer	For profit	12	12	3	2003
National Cancer Institute (NCI)	Government	9	0	3	1996
Bracco	For profit	4	4	2	2006
American College of Radiology	Academic/Hospital	3	3	2	2000
Guerbet	For profit	2	1	2	2010
University of Washington	Academic/Hospital	2	0	2	2001
Vanderbilt University	Academic/Hospital	2	2	2	2012
American Society of Head and Neck Radiology	Academic/Hospital	1	0	1	2012
Case Western Reserve University	Academic/Hospital	1	1	1	2013
Cornell University	Academic/Hospital	1	0	1	2000
Emory University	Academic/Hospital	1	1	1	2015
Maastricht University	Academic/Hospital	1	1	1	2009
Methodist Cancer Center, Houston, Texas	Academic/Hospital	1	0	1	2016
National Heart, Lung, and Blood Institute (NHLBI)	Government	1	1	1	2011
National Institutes of Health (NIH)	Government	1	1	1	1998
National Taiwan University	Academic/Hospital	1	1	1	2012
Northwestern University	Academic/Hospital	1	1	1	1996
Ohio State University	Academic/Hospital	1	1	1	2014
Paracelsus Medical University	Academic/Hospital	1	1	1	2013
Pennsylvania State University	Academic/Hospital	1	1	1	2009

27 organizations

Page 1 / 2

Marketing (2)

Organization	Org type	Relationship	Date
Bayer	For profit	NDA2	Jun 2, 1988
Bayer	For profit	NDA	Jun 2, 1988