gc1008
mAbexperimental
Clinical trial activity
12 trials · 17 clinical orgs · 0 marketing orgs
Phase 1
8
Phase 2
5
Phase 3
0
Phase 4
0
Earliest trial started Jul 1, 2005 (NCT00125385)
Timeline
Indications
Studied for
- Brain Neoplasms · Phase 2
- Breast Neoplasms · Phase 2
- Carcinoma, Non-Small-Cell Lung · Phase 1/Phase 2
- Carcinoma, Renal Cell · Phase 1
- Glomerulosclerosis, Focal Segmental · Phase 1
- Idiopathic Pulmonary Fibrosis · Phase 1
- Melanoma · Phase 1
- Mesothelioma · Phase 2
- Osteogenesis Imperfecta · Phase 1
- Polycythemia Vera · Phase 1
- Primary Myelofibrosis · Phase 1
- Scleroderma, Diffuse · Phase 1
- Sclerosis · Phase 2
Mechanism of action
- Transforming growth factor beta-1INHIBITOR
TGFB1 inhibitor
- Transforming growth factor beta-3INHIBITOR
TGFB3 inhibitor
- Transforming growth factor beta-2INHIBITOR
TGFB2 inhibitor
Chemistry & pharmacology
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
- Multi-specific
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL1743022 ↗
Also known as
- fresolimumab
- fresolimumab
- fresolimumab
- fresolimumab
- gc1008
- gc1008
- gc1008
- gc 1008
- gc 1008
- gc-1008
- gc-1008
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT03064074 | Phase 1 | Apr 1, 2017 | Baylor University, Genzyme, Hugo W. Moser Research Institute at Kennedy Krieger, Inc., Oregon Health and Science University, Rockefeller University, Shriners Hospitals for Children, University of California, Los Angeles, University of Nebraska, University of South Florida |
| NCT02581787 | Phase 1/Phase 2 (Phase 2) | Aug 1, 2016 | National Cancer Institute (NCI), Stanford University |
| NCT01665391 | Phase 2 | Aug 1, 2012 | Genzyme |
| NCT01472731 | Phase 2 | Dec 1, 2011 | Genzyme, University of Groningen |
| NCT01401062 | Phase 2 | Jul 1, 2011 | Cornell University, New York University, University of California, Los Angeles |
| NCT01291784 | Phase 1 | Feb 1, 2011 | Icahn School of Medicine at Mount Sinai |
| NCT01284322 | Phase 1 | Jan 1, 2011 | Boston University |
| NCT01112293 | Phase 2 | Apr 1, 2010 | University of Pennsylvania |
| NCT00464321 | Phase 1 | May 1, 2007 | Genzyme |
| NCT00356460 | Phase 1 | Sep 1, 2006 | Genzyme |
| NCT00923169 | Phase 1 | Jul 9, 2006 | National Cancer Institute (NCI) |
| NCT00125385 | Phase 1 | Jul 1, 2005 | Genzyme |
Showing 12 of 12 trials
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Organizations
Research & Development (17)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Genzyme | For profit | 6 | 4 | 2 | 2005 |
| National Cancer Institute (NCI) | Government | 2 | 1 | 2 | 2006 |
| University of California, Los Angeles | Academic/Hospital | 2 | 0 | 2 | 2011 |
| Baylor University | Academic/Hospital | 1 | 1 | 1 | 2017 |
| Boston University | Academic/Hospital | 1 | 1 | 1 | 2011 |
| Cornell University | Academic/Hospital | 1 | 1 | 1 | 2011 |
| Hugo W. Moser Research Institute at Kennedy Krieger, Inc. | Academic/Hospital | 1 | 0 | 1 | 2017 |
| Icahn School of Medicine at Mount Sinai | Academic/Hospital | 1 | 1 | 1 | 2011 |
| New York University | Academic/Hospital | 1 | 0 | 1 | 2011 |
| Oregon Health and Science University | Academic/Hospital | 1 | 0 | 1 | 2017 |
| Rockefeller University | Academic/Hospital | 1 | 0 | 1 | 2017 |
| Shriners Hospitals for Children | Academic/Hospital | 1 | 0 | 1 | 2017 |
| Stanford University | Academic/Hospital | 1 | 1 | 1 | 2016 |
| University of Groningen | Academic/Hospital | 1 | 1 | 1 | 2011 |
| University of Nebraska | Academic/Hospital | 1 | 0 | 1 | 2017 |
| University of Pennsylvania | Academic/Hospital | 1 | 1 | 1 | 2010 |
| University of South Florida | Academic/Hospital | 1 | 0 | 1 | 2017 |
17 organizations
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