pantothenic acid
Small moleculeapproved
Approved
Dec 29, 1993
PANTOTHENIC ACID, (±)- is a racemic mixture of D-pantothenic acid and L-pantothenic acid. Only dextrorotatory isomer, also called vitamin B5, possess biological activity. Tht levorotatory form is an antagonist of D-pantothenic acid as was shown in animal experiments. — NCATS
Clinical trial activity
9 trials · 13 clinical orgs · 1 marketing orgs
Phase 1
2
Phase 2
4
Phase 3
2
Phase 4
1
Earliest trial started Apr 1, 2012 (NCT01900041)
Timeline
Indications
Mechanism of action
Acyl coenzyme A:cholesterol acyltransferase activator
Combination products
vitape
with vitamin e, folic acid, cyanocobalamin, vitamin c, nicotinamide, thiamine, biotin, pyridoxine, riboflavin, vitamin a, phytonadione, ergocalciferol
Approval history
- approvedPriority reviewDec 29, 1993
Chemistry & pharmacology
Loading structure…
SMILES
CC(C)(CO)[C@@H](O)C(=O)NCCC(=O)O- Mol. weight
- 219.24 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
- Delivery
- Parenteral
- Availability
- Discontinued
Oral
No
Parenteral
Yes
Topical
No
Sources
- ChEMBLCHEMBL1594 ↗
- WikipediaPantothenic acid ↗
- NCATS66Y94D1203 ↗
- ChEMBLCHEMBL1901349 ↗
- NCATS19F5HK2737 ↗
Also known as
- calcium pantothenate
- calcium pantothenate
- calcium pantothenate
- calcium pantothenate
- calcium pantothenate
- calcium pantothenate
- calcium pantothenate
- calc pantoth
- cantopal
- d-pantothenic acid
- d-pantothenic acid
- d-pantothenic acid
- pantothenate
- pantothenate
- (+)-pantothenic acid
- (+)-pantothenic acid
- (+)-pantothenic acid
- pantothenic acid
- pantothenic acid
- pantothenic acid
- pantothenic acid
- pantothenic acid
- pantothenic acid
- pantothenic acid
- pantovigar
- vitamin b5
- vitamin b5
- vitamin b5
- vitamin b5
- vitamin b 5
- vitamin b 5
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06377111 | Phase 1 | Aug 31, 2024 | University of Toronto |
| NCT05701501 | N/A | Feb 1, 2023 | Changhai Hospital, University of Science and Technology of China |
| NCT05943860 | N/A | Sep 13, 2021 | Merz |
| NCT04880889 | Phase 3 | Sep 1, 2021 | Biolab Sanus Farmaceutica, Medcin Instituto da Pele |
| NCT05012735 | Phase 1 | Jul 19, 2021 | Johnson and Johnson, SGS Life Sciences |
| NCT04147624 | Phase 2 | Dec 1, 2019 | American Academy of Neurology, University of Miami |
| NCT03659201 | Phase 4 | Sep 30, 2018 | EMS S/A, Lux Biosciences, Inc. |
| NCT03095872 | Phase 3 | Mar 1, 2017 | RWTH Aachen University |
| NCT01900041 | Phase 2 | Apr 1, 2012 | Merz |
Showing 9 of 9 trials
Page 1 / 1
Organizations
Research & Development (13)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Merz | For profit | 2 | 2 | 2 | 2012 |
| American Academy of Neurology | Academic/Hospital | 1 | 0 | 1 | 2019 |
| Biolab Sanus Farmaceutica | For profit | 1 | 1 | 1 | 2021 |
| Changhai Hospital | Academic/Hospital | 1 | 1 | 1 | 2023 |
| EMS S/A | For profit | 1 | 1 | 1 | 2018 |
| Johnson and Johnson | For profit | 1 | 1 | 1 | 2021 |
| Lux Biosciences, Inc. | For profit | 1 | 0 | 1 | 2018 |
| Medcin Instituto da Pele | Academic/Hospital | 1 | 0 | 1 | 2021 |
| RWTH Aachen University | Academic/Hospital | 1 | 1 | 1 | 2017 |
| SGS Life Sciences | For profit | 1 | 0 | 1 | 2021 |
| University of Miami | Academic/Hospital | 1 | 1 | 1 | 2019 |
| University of Science and Technology of China | Academic/Hospital | 1 | 0 | 1 | 2023 |
| University of Toronto | Academic/Hospital | 1 | 1 | 1 | 2024 |
13 organizations
Page 1 / 1