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Chronic Kidney Disease-Mineral and Bone Disorder
Decalcification of bone or abnormal bone development due to chronic KIDNEY DISEASES, in which 1,25-DIHYDROXYVITAMIN D3 synthesis by the kidneys is impaired, leading to reduced negative feedback on PARATHYROID HORMONE. The resulting SECONDARY HYPERPARATHYROIDISM eventually leads to bone disorders.
Drugs by status
Approved for this indication (6)
Phase 4 trials (51)
- ezetimibe
- allopurinol
- vitamin d3
- methylprednisolone
- denosumab
- lesinurad
- calcium carbonate
- darbepoetin alfa
- epoetin
- methoxy polyethylene glycol-epoetin beta
- prednisone
- elbasvir
- empagliflozin
- ferric carboxymaltose
- fumaric acid esters
- tacrolimus
- doxercalciferol
- calcium
- iron dextran
- iron sucrose
- pamidronate
- evolocumab
- atorvastatin
- febuxostat
- valsartan
- teriparatide
- roxadustat
- semaglutide
- sevelamer
- cyclosporine
- +21 more
Phase 3 trials (26)
- iron
- cinacalcet
- acetylcysteine
- calcium citrate
- dulaglutide
- enarodustat
- keto-amino acids
- lanthanum
- nemolizumab
- patiromer
- pegol-sihematide
- sitagliptin
- sotagliflozin
- vadadustat
- ramipril
- curcumin
- sacubitril
- ravulizumab-cwvz
- ferrous sulfate
- magnesium citrate
- darbepoetin beta
- polynuclear iron(iii)-oxyhydroxide
- calcium magnesium acetate
- mt1013
- KT-301
- ap301
Phase 2 trials (38)
- asp8232
- Balcinrenone
- amg 223
- bps804
- medicinal charcoal
- eculizumab
- fu-zheng-qu-zhuo
- somatropin
- green propolis
- etelcalcetide
- lhw090
- menaquinone
- prs-080
- cyclophosphamide
- enoxaparin
- furosemide
- yougui
- zuogui
- allogeneic adipose derived mesenchymal stem cell
- cta018
- Vonafexor
- fludarabine
- eplerenone
- rituximab
- amiloride
- sodium chloride
- melphalan
- agalsidase beta
- sulforaphane
- camostat mesylate
- +8 more
Phase 1 trials (19)
Organizations
Organization Involved with Phase 4 Indications (8)
Organization Involved with Phase 3 Indications (1)
Organization Involved with Phase 2 Indications (10)
- KAI Pharmaceuticals
- Amgen
- National Center for Research Resources (NCRR)
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- Shanghai University of Traditional Chinese Medicine
- Columbia University
- Fudan University
- University of California, Los Angeles
- Anhui College of Traditional Chinese Medicine
- Shanghai University
Organization Involved with Other Experimental Indications (3)