ferric citrate
Trade name: AURYXIA
Small moleculeapproved
Approved
Sep 5, 2014
Ferric citrate or iron(III) citrate describes any of several complexes formed upon binding any of the several conjugate bases derived from citric acid with ferric ions. Most of these complexes are orange or red-brown. They contain two or more Fe(III) centers. — Wikipedia
Clinical trial activity
24 trials · 32 clinical orgs · 2 marketing orgs
Phase 1
1
Phase 2
16
Phase 3
12
Phase 4
6
Earliest trial started Mar 1, 2008 (NCT00648167)
Timeline
2010s
Indications
Approved for
Studied for
- Anemia, Iron-Deficiency · Phase 4
- Cardiovascular Diseases · Phase 3
- Chronic Kidney Disease-Mineral and Bone Disorder · Phase 3
- Disease Progression · Phase 3
- Healthy Volunteers · Phase 1
- Hyperphosphatemia · Phase 4
- Inflammation · Phase 4
- Iron · Phase 3
- Iron Deficiencies · Phase 3
- Kidney Diseases · Phase 3
- Kidney Failure, Chronic · Phase 4
- Phosphorus Metabolism Disorders · Phase 4
- Renal Insufficiency · Phase 4
- Renal Insufficiency, Chronic · Phase 4
Mechanism of action
- PhosphateSEQUESTERING AGENT
Phosphate sequestering agent
Approval history
- approvedSep 5, 2014
Chemistry & pharmacology
- Mol. weight
- 262.96 g/mol
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
- Delivery
- Oral
- Availability
- Prescription Only
Oral
Yes
Parenteral
No
Topical
No
Sources
- WikipediaIron(III) citrate ↗
- ChEMBLCHEMBL3301597 ↗
Also known as
- 1,2,3-propanetricarboxylic acid, 2-hydroxy-, iron(3+) salt (1:1)
- 2-hydroxy-1,2,3-propanetricarboxylic acid iron salt
- 2-hydroxy-1,2,3-propanetricarboxylic acid iron salt
- ferric citrate
- ferric citrate
- ferric citrate
- ferric citrate
- ferric citrate
- ferric citrate
- ferric citrate
- ferric citrate
- ferric citrate
- ferric citrate, 59fe-labeled cpd
- ferric citrate anhydrous
- ferric citrate coordination complex
- ferric citrate dihydrate
- ferric citrate hydrate
- ferric citrate hydrate
- ferric citrate iron(+3) salt
- ferric citrate, iron salt, 59fe-labeled cpd
- ferric citrate monohydrate
- ferric citrate trihydrate
- ferric citrate trihydrate
- ferric-citric acid
- ferrum citricum
- ferrum citricum
- fexeric
- fexeric
- fexeric
- fexeric
- iron(iii) citrate
- iron(iii) citrate tribasic
- iron(iii) citrate tribasic
- jtt-751
- krx-0502
- krx-0502
- zerenex
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT05085275 | Phase 3 | Nov 30, 2021 | Akebia Therapeutics, USRC Kidney Research |
| NCT04922645 | Phase 4 | Jun 29, 2021 | Akebia Therapeutics, USRC Kidney Research |
| NCT04741646 | Phase 2 | Apr 1, 2021 | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), University of California, Los Angeles |
| NCT04649411 | Phase 3 | Feb 28, 2021 | Keryx |
| NCT04523727 | Phase 3 | Jan 31, 2021 | Keryx |
| NCT04543812 | Phase 3 | Oct 14, 2020 | Panion & BF Biotech Inc., Taipei Veteran General hospital |
| NCT04299633 | Phase 1 | Mar 31, 2020 | Akebia Therapeutics |
| NCT03984760 | Phase 3 | Jun 30, 2019 | Changhai Hospital, China Medical University, Dalian Medical University, Daping Hospital, Guangdong Pharmaceutical University, Guangzhou Medical University, Henan Provincal People's Hospital, Jiangxi Provincial People's Hospital, Jilin University, Meihekou Central Hospital, Panion & BF Biotech Inc., People's Liberation Army of China, Qingdao University, Tonghua Central Hospital, Wuhan University |
| NCT04456803 | Phase 3 | May 24, 2019 | Sinomune Pharmaceutical Co., Ltd |
| NCT03236246 | Phase 4 | Jul 26, 2017 | Keryx |
| NCT03055598 | Phase 4 | May 11, 2017 | Baylor University, Keryx |
| NCT03256838 | Phase 4 | Apr 12, 2017 | Panion & BF Biotech Inc., Taipei Medical University |
| NCT03079869 | Phase 4 | Mar 1, 2017 | Kaiser Permanente, Keryx |
| NCT02888171 | N/A | Aug 1, 2016 | University of Alabama, Birmingham |
| NCT02661295 | Phase 4 | Jul 1, 2015 | Keryx, Winthrop University |
| NCT02492620 | Phase 3 | Mar 1, 2015 | Denver Nephrologists, P.C., Keryx |
| NCT02268994 | Phase 3 | Sep 1, 2014 | Denver Nephrology, Keryx, Northwell Health, Stanford University |
| NCT02128074 | Phase 2 | Apr 1, 2014 | Keryx |
| NCT01736397 | Phase 2 | Nov 1, 2012 | Keryx |
| NCT01554982 | Phase 3 | Aug 1, 2012 | Keryx |
Showing 20 of 24 trials
Page 1 / 2
Organizations
Research & Development (32)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Keryx | For profit | 14 | 10 | 3 | 2008 |
| Panion & BF Biotech Inc. | For profit | 4 | 4 | 2 | 2010 |
| Akebia Therapeutics | For profit | 3 | 1 | 3 | 2020 |
| USRC Kidney Research | Academic/Hospital | 2 | 2 | 2 | 2021 |
| Baylor University | Academic/Hospital | 1 | 1 | 1 | 2017 |
| Changhai Hospital | Academic/Hospital | 1 | 0 | 1 | 2019 |
| China Medical University | Academic/Hospital | 1 | 0 | 1 | 2019 |
| Dalian Medical University | Academic/Hospital | 1 | 0 | 1 | 2019 |
| Daping Hospital | Academic/Hospital | 1 | 0 | 1 | 2019 |
| Denver Nephrologists, P.C. | Academic/Hospital | 1 | 1 | 1 | 2015 |
| Denver Nephrology | Academic/Hospital | 1 | 0 | 1 | 2014 |
| Guangdong Pharmaceutical University | Academic/Hospital | 1 | 0 | 1 | 2019 |
| Guangzhou Medical University | Academic/Hospital | 1 | 0 | 1 | 2019 |
| Henan Provincal People's Hospital | Academic/Hospital | 1 | 0 | 1 | 2019 |
| Jiangxi Provincial People's Hospital | Academic/Hospital | 1 | 0 | 1 | 2019 |
| Jilin University | Academic/Hospital | 1 | 0 | 1 | 2019 |
| Kaiser Permanente | Academic/Hospital | 1 | 1 | 1 | 2017 |
| Meihekou Central Hospital | Academic/Hospital | 1 | 0 | 1 | 2019 |
| National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Government | 1 | 0 | 1 | 2021 |
| Northwell Health | Academic/Hospital | 1 | 0 | 1 | 2014 |
32 organizations
Page 1 / 2