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iron dextran

Trade name: INFeD

Small moleculeapproved

Approved

Apr 25, 1957

Sucroferric oxyhydroxide, sold under the brand name Velphoro, is a non-calcium, iron-based phosphate binder used for the control of serum phosphorus levels in adults with chronic kidney disease (CKD) on hemodialysis (HD) or peritoneal dialysis (PD). It is used in form of chewable tablets. — Wikipedia

Clinical trial activity

118 trials · 116 clinical orgs · 12 marketing orgs

Phase 1
7
Phase 2
45
Phase 3
30
Phase 4
47

Earliest trial started Feb 1, 2001 (NCT00236964)

Timeline

1950s

  1. Apr 25, 1957

    Earliest FDA Approval

  2. Apr 25, 1957

    Sanofi-Aventis — NDA Secondary Org

  3. Apr 25, 1957

    Sanofi-Aventis — Marketing Organization

1970s

  1. Apr 29, 1974

    Allergan — NDA Secondary Org

  2. Apr 29, 1974

    Allergan — Marketing Organization

1980s

  1. Mar 26, 1981

    New River Pharmaceuticals — NDA Secondary Org

  2. Mar 26, 1981

    New River Pharmaceuticals — Marketing Organization

1990s

  1. Feb 23, 1996

    Sankyo — Marketing Organization

  2. Feb 23, 1996

    Lutipold — NDA Secondary Org

  3. Feb 23, 1996

    Sankyo — NDA Secondary Org

2000s

  1. Jan 1, 2001

    Earliest Phase 3 Sponsor(trial)

  2. Jan 1, 2003

    Earliest Phase 2 Sponsor(trial)

  3. Jan 1, 2004

    Earliest Phase 1 Sponsor(trial)

2010s

  1. Mar 31, 2011

    West-Ward Pharmaceutical — Marketing Organization

  2. Mar 31, 2011

    Hikma — Marketing Organization

  3. Nov 27, 2013

    Fresenius — Marketing Organization

  4. Nov 27, 2013

    Fresenius — NDA Secondary Org

2020s

  1. Aug 8, 2025

    International Medication — Marketing Organization

  2. Aug 8, 2025

    Mylan — Marketing Organization

  3. Aug 8, 2025

    Sandoz — Marketing Organization

Indications

Approved for

Studied for

Mechanism of action

  • PhosphateBINDING AGENT

    Phosphate binding agent

  • Unspecified targetOTHER

    Supplement

  • PhosphateSEQUESTERING AGENT

    Phosphate sequestering agent

    It is a phosphate binder indicated for the control of serum phosphorus levels in patients with chronic kidney disease on dialysis

  • IronSupplementation

    Iron supplementation

Approval history

  • approvedPriority reviewApr 25, 1957

Chemistry & pharmacology

Mol. weight
398.14 g/mol
Chirality
Single Stereoisomer
Inorganic
No
Polymer
No
Delivery
Parenteral
Availability
Prescription Only

Oral

No

Parenteral

Yes

Topical

No

Sources

Also known as

  • apo-ferrous gluconate
  • dextran iron
  • dextriferron
  • eisen-sandoz
  • feg iron
  • fergon
  • fergon
  • fergon
  • ferric gluconate
  • ferric gluconate anhydrous
  • ferric gluconate, sodium salt
  • ferric gluconate trihydrate
  • ferric hydroxide sucrose complex
  • ferric hydroxide sucrose complex
  • ferric hydroxide sucrose complex
  • ferric oxide saccharated
  • ferric oxide, saccharated
  • ferric oxide, saccharated
  • ferric saccharate
  • ferric sodium gluconate complex
  • ferric sodium gluconate complex
  • ferri-saccharate
  • ferrlecit
  • ferrlecit
  • ferrlecit
  • ferrlecit
  • ferrlecit 100
  • ferroglucon
  • ferrogluconaat fna
  • ferroglyconicum
  • ferrous gluconate
  • ferrous gluconate
  • ferrous gluconate
  • ferrous gluconate
  • ferrous gluconate
  • ferrous gluconate
  • ferrum verla
  • glucoferron
  • hippiron
  • iron dextran
  • iron dextran
  • iron dextran
  • iron dextran
  • iron dextran
  • iron dextran
  • iron dextran complex
  • iron dextran complex
  • iron gluconate
  • iron(iii) hydroxide sucrose complex
  • iron(iii) hydroxide sucrose complex
  • iron(iii) hydroxide sucrose complex
  • iron(iii)-hydroxide sucrose complex
  • iron oxide saccharated
  • iron oxide saccharated
  • iron oxide saccharated
  • iron oxide (saccharated)
  • iron saccharate
  • iron saccharate
  • iron saccharate
  • iron saccharate
  • iron saccharate
  • iron-saccharate
  • iron sucrose
  • iron sucrose
  • iron sucrose
  • iron sucrose
  • iron sucrose
  • iron sucrose
  • iron sucrose complex
  • iron sucrose complex
  • iron sucrose complex
  • iron sugar
  • iron sugar
  • iron sugar
  • loesferron
  • losferron
  • low molecular weight iron dextran
  • polysaccharide iron complex
  • rulofer g
  • saccharated ferric oxide
  • saccharated ferric oxide
  • saccharated ferric oxide
  • saccharated ferric oxide
  • saccharated iron
  • saccharated iron
  • saccharated iron
  • saccharated iron oxide
  • saccharated iron oxide
  • saccharated iron oxide
  • saccharated iron oxide
  • saccharated iron oxide
  • sideromal
  • simron
  • sodium ferric gluconate
  • sodium ferric gluconate complex
  • sodium ferric gluconate complex
  • sodium ferric gluconate complex
  • sodium ferric gluconate complex
  • sodium ferric gluconate complex
  • sodium ferric gluconate complex
  • sodium ferric gluconate complex
  • sodium ferric gluconate complex
  • sodium ferric gluconate complex
  • sodium ferric gluconate complex in sucrose
  • sodium ferrigluconate
  • sodium iron(iii)gluconate
  • sucroferric oxyhydroxide
  • sucroferric oxyhydroxide
  • sucroferric oxyhydroxide
  • sucroferric oxyhydroxide
  • sucroferric oxyhydroxide
  • sucroferric oxyhydroxide
  • sucroferric oxyhydroxide
  • sucroferric oxyhydroxide
  • sucroferric oxyhydroxide
  • velphoro
  • velphoro
  • venofer
  • venofer
  • venofer
  • vitaferro brause
  • xi-921
  • xi-921

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT06366698Phase 3Nov 21, 2023University of California, Irvine
NCT06061393Phase 4Oct 30, 2023Western Galilee Hospital
NCT06012760N/AAug 30, 2023Zhejiang University
NCT05714176Phase 4Feb 1, 2023Menoufia University, Tanta University
NCT05960227Phase 2Jan 6, 2023University of Guadalajara
NCT06049693Phase 4Jan 1, 2023University of Athens
NCT05340465Phase 2Oct 10, 2022National Institutes of Health (NIH), University of Washington
NCT05292001Phase 4May 2, 2022Collins Medical Trust, Oregon Health and Science University
NCT05167734Phase 2Nov 30, 2021Mayo Clinic, National Heart, Lung, and Blood Institute (NHLBI)
NCT05047211Phase 4Oct 7, 2021University of Texas, Galveston
NCT04797832Phase 4Oct 18, 2020Technion University
NCT04587141Phase 3Jan 1, 2020Italian Group for the study of Inflammatory Bowel Disease (IG-IBD), University of Pavia
NCT04063033Phase 4Sep 1, 2019Technion University
NCT04046263Phase 4Sep 1, 2019University of Colorado, Denver
NCT03915327N/AJun 1, 2019Sichuan University
NCT03528564Phase 2Oct 1, 2018University of Toronto
NCT03438227Phase 4Apr 15, 2018Washington University in St. Louis
NCT03279536Phase 1/Phase 2 (Phase 2)Jul 1, 2017Assiut University
NCT02009943Phase 1Feb 1, 2017University of Colorado
NCT03009578Phase 3Feb 1, 2017Assiut University
Showing 20 of 118 trials
Page 1 / 6

Organizations

Research & Development (116)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Daiichi SankyoFor profit141332001
Watson PharmaceuticalsFor profit101032002
National Heart, Lung, and Blood Institute (NHLBI)Government5232004
PharmacosmosFor profit5422011
AMAG Pharmaceuticals, Inc.For profit3332010
Assiut UniversityAcademic/Hospital3322016
University of ColoradoAcademic/Hospital3332011
University of OxfordAcademic/Hospital3332008
American National Red CrossAcademic/Hospital2022011
AmgenFor profit2122004
Ben Gurion UniversityAcademic/Hospital2222005
Blood Center of WisconsinAcademic/Hospital2022011
ClinStar, LLCFor profit2012008
Duke UniversityAcademic/Hospital2222011
Emek Medical CenterAcademic/Hospital2212016
Mayo ClinicAcademic/Hospital2222006
Papageorgiou General HospitalAcademic/Hospital2212005
Rijnstate HospitalAcademic/Hospital2212014
Technion UniversityAcademic/Hospital2212019
University of BarcelonaAcademic/Hospital2212005
116 organizations
Page 1 / 6

Marketing (17)

OrganizationOrg typeRelationshipDate
AllerganFor profitNDA2Apr 29, 1974
AllerganFor profitMKTGApr 29, 1974
FreseniusFor profitMKTGNov 27, 2013
FreseniusFor profitNDA2Nov 27, 2013
HikmaFor profitMKTGMar 31, 2011
International MedicationFor profitMKTGAug 8, 2025
LutipoldFor profitNDA2Feb 23, 1996
MylanFor profitMKTGAug 8, 2025
New River PharmaceuticalsFor profitNDA2Mar 26, 1981
New River PharmaceuticalsFor profitMKTGMar 26, 1981
SandozFor profitMKTGAug 8, 2025
SankyoFor profitMKTGFeb 23, 1996
SankyoFor profitNDA2Feb 23, 1996
SanofiFor profitNDA—
Sanofi-AventisFor profitNDA2Apr 25, 1957
Sanofi-AventisFor profitMKTGApr 25, 1957
West-Ward PharmaceuticalFor profitMKTGMar 31, 2011