calcium citrate

Small moleculeexperimental

Calcium citrate is the calcium salt of citric acid. It is commonly used as a food additive (E333), usually as a preservative, but sometimes for flavor. In this sense, it is similar to sodium citrate. Calcium citrate is also found in some dietary calcium supplements. Calcium makes up 24.1% of calcium citrate (anhydrous) and 21.1% of calcium citrate (tetrahydrate) by mass. The tetrahydrate occurs in nature as the mineral Earlandite. — Wikipedia

Clinical trial activity

37 trials · 46 clinical orgs · 6 marketing orgs

Phase 1

Phase 2

Phase 3

Phase 4

Earliest trial started Feb 1, 2002 (NCT00892476)

Timeline

2000s

Jan 1, 2002
Earliest Phase 1 Sponsor(trial)
Jan 1, 2002
Earliest Phase 3 Sponsor(trial)
Jan 1, 2006
Earliest Phase 2 Sponsor(trial)

2010s

Jun 15, 2017
Fresenius — NDA Secondary Org
Oct 29, 2018
Hq Speciality Pharma — NDA Secondary Org

2020s

Oct 14, 2022
Nivagen Pharmaceuticals Inc. — Marketing Organization
Aug 21, 2023
B. Braun — Marketing Organization
Sep 5, 2023
Amneal Pharmaceuticals — Marketing Organization
Oct 19, 2023
Somerset Pharmaceuticals — Marketing Organization

Indications

Approved for

Hypocalcemia

Studied for

Mechanism of action

Unspecified targetSupplementation
Supplementation
CalciumSupplementation
Calcium supplementation

Chemistry & pharmacology

Loading structure…

SMILES

O=C([O-])[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.O=C([O-])[C@H](O)[C@@H](O)[C@H](O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O)[C@H](O)CO.[Ca+2]

Mol. weight: 592.51 g/mol
Chirality: Single Stereoisomer
Inorganic: No
Polymer: No
Availability: Prescription Only

Oral

Parenteral

Topical

Sources

Also known as

calcarea gluconica
calcarea gluconica
calcii gluconas
calcii gluconas
calciofon
calcium citrate
calcium citrate
calcium citrate
calcium citrate
calcium citrate
calcium citrate
calcium citrate
calcium citrate malate
calcium citrate malate
calcium d-gluconate
calcium d-gluconate lactobionate
calcium d-gluconate lactobionate
calcium di-gluconate
calcium di-gluconate
calcium glubionate
calcium glubionate
calcium glubionate
calcium glubionate
calcium glubionate
calcium glubionate anhydrous
calcium glubionate anhydrous
calcium glubionate hydrate
calcium glubionate hydrate
calcium glubionate monohydrate
calcium gluconate
calcium gluconate
calcium gluconate
calcium gluconate
calcium gluconate
calcium gluconate
calcium gluconate
calcium gluconate
calcium gluconate
calcium gluconate anhydrous
calcium gluconate anhydrous
calcium gluconate, anhydrous
calcium gluconate, anhydrous
calcium gluconate monohydrate
calcium médifa
calcium-sandoz
calc-sandoz
calglucon
calglucon
citracal
citracal
(d-gluconato)(lactobionato)calcium
(d-gluconato)(lactobionato)calcium
d-gluconic acid, calcium salt (2:1)
d-gluconic acid, calcium salt (2:1)
glubionate calcium
glubionate calcium
glubionate calcium
glubionate calcium monohydrate
h-f antidote
kaon
kaon
katorin
katorin
neo-calglucon
neo-calglucon
prismocitrate 18
tricalcium citrate
tricalcium citrate

Clinical trials

NCT ID	Phase	Start date	Sponsor(s)
NCT06671665	N/A	Nov 7, 2024	Cairo University
NCT05998863	Phase 3	Jan 1, 2024	The University of Texas, Dallas
NCT05399537	Phase 3	Nov 30, 2022	Baxalta
NCT05033054	Phase 1	Dec 15, 2021	The University of Texas, Dallas
NCT04620252	Early Phase 1 (Phase 1)	Jan 4, 2021	University of Michigan
NCT04369742	Phase 2	Apr 15, 2020	New York University, State University of New York, Brooklyn
NCT03994172	Phase 4	Jul 1, 2019	Department of Veteran Affairs, University of California, San Francisco
NCT04297839	Phase 3	Feb 12, 2019	University of Sao Paulo
NCT06807905	Phase 4	Feb 1, 2019	University of Ljubljana
NCT03812380	Phase 3	Jan 1, 2019	The University of Texas, Dallas
NCT03425747	Phase 4	Sep 1, 2018	Campus Bio-Medico University
NCT03634917	Phase 3	Sep 1, 2018	Technical University of Dresden
NCT03621553	Phase 4	Sep 1, 2018	The University of Texas, Dallas
NCT03424239	Phase 4	May 1, 2018	Harvard University
NCT03232034	N/A	May 1, 2017	University of Bath
NCT03565913	Phase 2/Phase 3 (Phase 3)	Jan 22, 2017	The University of Texas, Dallas
NCT02830789	N/A	Dec 31, 2016	Aarhus University
NCT02875587	Phase 2	Oct 1, 2016	Aljazeera Hospital
NCT02860130	Phase 3	Sep 1, 2016	Baxalta
NCT02580604	Early Phase 1 (Phase 1)	Nov 1, 2015	University of Colorado, Denver

Showing 20 of 37 trials

Page 1 / 2

Organizations

Research & Development (46)

Organization	Org type	Trials	As lead sponsor	Phases	Earliest year
National Cancer Institute (NCI)	Government	6	2	2	2006
Harvard University	Academic/Hospital	5	3	3	2006
The University of Texas, Dallas	Academic/Hospital	5	5	3	2017
Mayo Clinic	Academic/Hospital	4	1	1	2006
Baxalta	For profit	2	2	1	2016
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)	Government	2	1	2	2002
North Central Cancer Treatment Group	Academic/Hospital	2	0	1	2006
Texas A&M University	Academic/Hospital	2	2	1	2004
Aarhus University	Academic/Hospital	1	1	1	2016
Aljazeera Hospital	Academic/Hospital	1	1	1	2016
Cairo University	Academic/Hospital	1	1	1	2024
Campus Bio-Medico University	Academic/Hospital	1	1	1	2018
Canadian Cancer Trials Group	Academic/Hospital	1	1	1	2006
Creighton University	Academic/Hospital	1	1	1	2007
Curves International	For profit	1	0	1	2009
Department of Veteran Affairs	Government	1	1	1	2019
Eli Lilly	For profit	1	0	1	2011
Fresenius	For profit	1	1	1	2008
Herbert Irving Comprehensive Cancer Center	Academic/Hospital	1	0	1	2006
Icahn School of Medicine at Mount Sinai	Academic/Hospital	1	0	1	2012

46 organizations

Page 1 / 3

Marketing (7)

Organization	Org type	Relationship	Date
Amneal Pharmaceuticals	For profit	MKTG	Sep 5, 2023
Amneal Pharmaceuticals	For profit	SYN	Sep 5, 2023
B. Braun	For profit	MKTG	Aug 21, 2023
Fresenius	For profit	NDA2	Jun 15, 2017
Hq Speciality Pharma	For profit	NDA2	Oct 29, 2018
Nivagen Pharmaceuticals Inc.	For profit	MKTG	Oct 14, 2022
Somerset Pharmaceuticals	For profit	MKTG	Oct 19, 2023