phosphate
Phosphoric acid, also known as orthophosphoric acid, is used in dentistry and orthodontics to clean and roughen the surfaces of teeth where dental appliances or fillings will be placed. In addition, this acid is a part of product ProcalAmine, which is indicated for peripheral administration in adults to preserve body protein and improve nitrogen balance in well-nourished, mildly catabolic patients who require short-term parenteral nutrition. In combination with dextrose (glucose) and levulose (fructose), phosphoric acid relieves nausea due to upset stomach from intestinal flu, stomach flu, and food or drink indiscretions. In addition, homeopathic product, Brain power contains also phosphoric acid and this product is used to temporarily relieve symptoms of general physical weakness and listlessness, including: fatigue; sore muscles & joints; dry skin; absence of sexual desire; occasional sleeplessness. — NCATS
Clinical trial activity
31 trials · 42 clinical orgs · 0 marketing orgs
Earliest trial started Oct 1, 2004 (NCT00089804)
Timeline
Indications
Approved for
Studied for
- Alzheimer Disease · Phase 2
- Angioedema · Phase 3
- Bronchopulmonary Dysplasia · Phase 1
- Chronic Kidney Disease-Mineral and Bone Disorder · Phase 1
- COVID-19 · Phase 1/Phase 2
- COVID-19 Vaccines · Phase 1/Phase 2
- Critical Care · Phase 4
- Familial Hypophosphatemic Rickets · Phase 3
- Genetic Diseases, X-Linked · Early Phase 1
- Head and Neck Neoplasms · Phase 4
- Healthy Volunteers · Phase 1/Phase 2
- Hodgkin Disease · Phase 2
- Hypercalciuria · Early Phase 1
- Hypoparathyroidism · Phase 4
- Hypophosphatemia · Early Phase 1
- Influenza A Virus, H7N9 Subtype · Phase 1/Phase 2
- Influenza, Human · Phase 3
- Irritable Bowel Syndrome · Phase 4
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive · Phase 2
- Leukemia, Myeloid, Acute · Phase 2
- Lupus Erythematosus, Systemic · Phase 3
- Lupus Nephritis · Phase 3
- Lymphoma, Non-Hodgkin · Phase 2
- Lymphoproliferative Disorders · Phase 1
- Myelodysplastic Syndromes · Phase 2
- Neoplasms · Phase 1
- Pneumonia, Viral · Phase 1/Phase 2
- Precursor Cell Lymphoblastic Leukemia-Lymphoma · Phase 2
- Prostheses and Implants · Phase 2
- Refeeding Syndrome · Phase 4
- Renal Insufficiency, Chronic · Phase 1
- Respiratory Syncytial Viruses · Phase 2
- Respiratory Syncytial Virus Infections · Phase 3
- Rickets · Early Phase 1
- Severe Acute Respiratory Syndrome · Phase 1
- Transplantation · Phase 1
Mechanism of action
- PhosphateSupplementation
supplementation - phosphate
- Unspecified targetBuffer
buffer
Chemistry & pharmacology
SMILES
[O-]P([O-])([O-])=O- Mol. weight
- 94.9714 g/mol
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaPhosphate-buffered saline ↗
- NCATSNK08V8K8HR ↗
- WikipediaPhosphate ↗
Also known as
- phosphate
- phosphate
- phosphate buffer
- phosphate buffer
- phosphate buffered saline
- phosphate buffered saline
- phosphate-buffered saline
- phosphate-buffered saline
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07288944 | N/A | Jan 31, 2026 | Caboolture Hospital, Queensland University of Technology |
| NCT07302256 | Phase 1 | Dec 16, 2025 | China National Biotec Group Co., Ltd, Government of China |
| NCT06741072 | Phase 1 | Jul 1, 2025 | Ohio State University |
| NCT04830800 | Phase 1/Phase 2 (Phase 2) | Mar 10, 2021 | Government of Thailand, Government of Vietnam, Hanoi Medical University, Institute of Vaccines and Medical Biologicals, Vietnam |
| NCT04215965 | Phase 4 | May 2, 2020 | Aix-University of Marseille |
| NCT03857841 | Phase 1 | Jun 20, 2019 | United Therapeutics |
| NCT03771105 | Early Phase 1 (Phase 1) | Jan 1, 2019 | Yale University |
| NCT03267797 | Phase 2 | Dec 7, 2018 | Tabriz Medical University |
| NCT03369808 | Phase 1/Phase 2 (Phase 2) | Dec 29, 2017 | China National Biotec Group Co., Ltd, Government of China |
| NCT04013776 | N/A | May 1, 2017 | Queen's University, Belfast |
| NCT03026348 | Phase 2 | Jan 1, 2017 | Novavax |
| NCT02935192 | Phase 3 | Nov 28, 2016 | Cliniical Center of Serbia, Comac Medical, Institute of Virology, Vaccines and Sera, Torlak, PATH, World Health Organization |
| NCT02915705 | Phase 3 | Sep 1, 2016 | Kyowa Hakko Kirin, Ultragenyx Inc. |
| NCT02652884 | Phase 4 | Jan 1, 2016 | Hospital Italiano de Buenos Aires |
| NCT02608502 | Phase 3 | Nov 1, 2015 | Novavax |
| NCT02585700 | Phase 1 | Nov 1, 2015 | Department of Health and Human Services, Institute of Virology, Vaccines and Sera, Torlak, World Health Organization |
| NCT02593071 | Phase 2 | Oct 1, 2015 | Novavax |
| NCT02386904 | Phase 4 | Mar 1, 2015 | Dow University of Health Sciences, Nabiqasim Industries (Pvt) Ltd |
| NCT02095392 | N/A | Apr 1, 2014 | Friedrich Schiller University |
| NCT02880072 | Phase 4 | Mar 1, 2014 | University of Copenhagen |
Organizations
Research & Development (42)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| National Institute of Allergy and Infectious Diseases (NIAID) | Government | 3 | 3 | 1 | 2011 |
| Novavax | For profit | 3 | 3 | 2 | 2015 |
| China National Biotec Group Co., Ltd | For profit | 2 | 2 | 2 | 2017 |
| Government of China | Government | 2 | 0 | 2 | 2017 |
| Institute of Virology, Vaccines and Sera, Torlak | Academic/Hospital | 2 | 2 | 2 | 2015 |
| Shire | For profit | 2 | 2 | 1 | 2005 |
| World Health Organization | Government | 2 | 0 | 2 | 2015 |
| Aix-University of Marseille | Academic/Hospital | 1 | 1 | 1 | 2020 |
| Astellas | For profit | 1 | 1 | 1 | 2006 |
| Baxalta | For profit | 1 | 1 | 1 | 2007 |
| BiondVax Pharmaceuticals | For profit | 1 | 1 | 1 | 2009 |
| Caboolture Hospital | Academic/Hospital | 1 | 1 | 1 | 2026 |
| Cliniical Center of Serbia | Academic/Hospital | 1 | 0 | 1 | 2016 |
| Comac Medical | For profit | 1 | 0 | 1 | 2016 |
| Department of Health and Human Services | Government | 1 | 0 | 1 | 2015 |
| Dow University of Health Sciences | Academic/Hospital | 1 | 0 | 1 | 2015 |
| Dyax | For profit | 1 | 0 | 1 | 2007 |
| Friedrich Schiller University | Academic/Hospital | 1 | 1 | 1 | 2014 |
| Government of Thailand | Government | 1 | 0 | 1 | 2021 |
| Government of Vietnam | Government | 1 | 0 | 1 | 2021 |