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sulforaphane

Small moleculeexperimental

Sulforaphane is a phytochemical within the isothiocyanate group of organosulfur compounds. It is produced when the enzyme myrosinase transforms glucoraphanin, a glucosinolate, into sulforaphane upon damage to the plant, which allows the two compounds to mix and react. — Wikipedia

Clinical trial activity

60 trials · 63 clinical orgs · 0 marketing orgs

Phase 1
12
Phase 2
31
Phase 3
2
Phase 4
3

Earliest trial started Jan 1, 2005 (NCT00255775)

Timeline

2000s

  1. Jan 1, 2008

    Earliest Phase 1 Sponsor(trial)

  2. Jan 1, 2009

    Earliest Phase 2 Sponsor(trial)

2010s

  1. Jan 1, 2018

    Earliest Phase 3 Sponsor(trial)

Indications

Approved for

Studied for

Mechanism of action

Chemistry & pharmacology

Loading structure…

SMILES

C[S+]([O-])CCCCN=C=S
Mol. weight
177.29 g/mol
Lipinski Ro5
Pass
Rule of 3
No
Chirality
Achiral Molecule
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • 1-isothiocyanato-4-methylsulphinylbutane
  • 4-methylsulphinylbutyl glucosinolate
  • broccoli sprout extract
  • broccoli sprout extract
  • brocooli sprout extract
  • methylsulfoxybutylisothiocyanate
  • (r)-sulforaphane
  • (r)-sulforaphane
  • sfx-01
  • sulfaphane
  • sulforafan
  • sulforaphane
  • sulforaphane
  • sulforaphane
  • sulforaphane
  • (-)-sulforaphane
  • (-)-sulforaphane
  • sulforaphane, (r)-
  • sulphoraphane

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT07040280Phase 2Oct 31, 2025Eastern Cooperative Oncology Group, National Institutes of Health (NIH), University of Pittsburgh
NCT07297576N/AOct 22, 2025China Academy of Chinese Medical Sciences
NCT06594536N/ADec 1, 2024Assistance Publique - Hôpitaux de Paris
NCT07047976N/ASep 20, 2024Central South University
NCT05797506Phase 2May 3, 2023National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), University of Rochester, University of Virginia
NCT05653492Phase 2Mar 1, 2023Renal Research Institute, University of Rochester
NCT05408559Phase 1/Phase 2 (Phase 2)Jul 1, 2022Texas Tech University
NCT04848792N/AApr 1, 2022Northern Arizona University, Villanova University
NCT05224492Phase 4Feb 21, 2022Sunshine Specialty Health Care
NCT05153174Phase 1/Phase 2 (Phase 2)Dec 1, 2021National Institutes of Health (NIH), University of Rochester
NCT05084365Phase 2Oct 10, 2021Central South University
NCT04608903N/ASep 30, 2021Fluminense Federal University
NCT05233579N/AJun 25, 2021University of California, Davis
NCT04805957N/AApr 1, 2021Rutgers University
NCT04521868Phase 2Aug 31, 2020Central South University
NCT04246905Phase 2Feb 1, 2020Central South University
NCT04252261Phase 2Feb 1, 2020Central South University
NCT04213391N/AJan 1, 2020Zhejiang University
NCT04364360N/AJan 1, 2020Quadram Institute, University of Oxford
NCT05148169Phase 4Jan 1, 2020Jiao Tong University
Showing 20 of 60 trials
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Organizations

Research & Development (63)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Johns Hopkins UniversityAcademic/Hospital14932005
Central South UniversityAcademic/Hospital8732016
National Cancer Institute (NCI)Government7032005
University of PittsburghAcademic/Hospital5322011
Department of Veteran AffairsGovernment3222010
Jiao Tong UniversityAcademic/Hospital3322018
National Institutes of Health (NIH)Government3012018
Oregon Health and Science UniversityAcademic/Hospital3222009
State University of New York, BuffaloAcademic/Hospital3222010
University of RochesterAcademic/Hospital3312021
Evgen PharmaFor profit2212016
Quadram InstituteAcademic/Hospital2112019
Rutgers UniversityAcademic/Hospital2222016
Texas Tech UniversityAcademic/Hospital2212019
University of East AngliaAcademic/Hospital2112019
University of MassachusettsAcademic/Hospital2212011
University of North Carolina at Chapel HillAcademic/Hospital2222013
University of WashingtonAcademic/Hospital2222008
Assistance Publique - Hôpitaux de ParisAcademic/Hospital1112024
Breast Cancer Research FoundationAcademic/Hospital1012009
63 organizations
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