CDEK
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menaquinone

Trade name: vitamin k2

Small moleculeexperimental

Vitamin K is a fat-soluble vitamin, which exists in two different forms in nature: vitamin K1 (phylloquinone or phytonadione) and vitamin K2 (menaquinones), a feature of which is a long polyprenyl lateral chain. Menaquinone-7 (MK-7) is a form of vitamin K2 that occurs naturally in some animal-derived and is available as an ingredient of dietary supplements. A novel method of marking five different cis/trans isomers of vitamin K2 (MK-7) (including 6-CIS form) in dietary supplements recently was developed and validated. — NCATS

Clinical trial activity

44 trials · 41 clinical orgs · 0 marketing orgs

Phase 1
6
Phase 2
14
Phase 3
4
Phase 4
6

Earliest trial started Jan 1, 2007 (NCT00402974)

Timeline

2000s

  1. Jan 1, 2008

    Earliest Phase 3 Sponsor(trial)

2010s

  1. Jan 1, 2011

    Earliest Phase 2 Sponsor(trial)

  2. Jan 1, 2013

    Earliest Phase 1 Sponsor(trial)

Indications

Approved for

Studied for

Mechanism of action

Chemistry & pharmacology

Loading structure…

SMILES

CC(C)=CCC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC1=C(C)C(=O)C2=CC=CC=C2C1=O
Mol. weight
648.9992 g/mol
Lipinski Ro5
2 violation(s)
Rule of 3
No
Chirality
Achiral Molecule
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • menaquinone
  • menaquinone
  • menaquinone
  • menaquinone
  • menaquinone 7
  • menaquinone 7
  • menaquinone 7
  • menaquinone-7
  • menaquinone-7
  • menaquinone-7
  • menaquinone-7
  • vitamin k2
  • vitamin k2
  • vitamin k2
  • vitamin k2(35)
  • vitamin mk 7

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT07206537N/AApr 1, 2025Ain Shams University
NCT06707909Phase 4Nov 23, 2024Cairo University
NCT05943457N/ASep 30, 2023Lebanese American University, Lesaffre International, Omicron Pharmaceuticals
NCT05942053Phase 4Jul 15, 2023Tanta University
NCT05500443N/ANov 30, 2022University of Southern Denmark
NCT05259046N/AJun 21, 2022University of Copenhagen
NCT04010578N/AOct 1, 2019European Commission, Maastricht University
NCT05285787Phase 2Mar 1, 2019Augusta University, Epizon Pharma, Inc.
NCT03243890Phase 1Jan 12, 2018University of Southern Denmark
NCT03305536Phase 2Jan 2, 2018Hopital St. Georges, Ajaltoun, Nattopharma, Omicron Pharmaceuticals
NCT03311321Phase 1/Phase 2 (Phase 2)Sep 13, 2017Augusta University
NCT04539418Phase 4Dec 1, 2016Catholic University of Salta, Universidad Católica de Salta
NCT02976246Phase 2/Phase 3 (Phase 3)Nov 1, 2016Steno Diabetes Center Copenhagen, University of Copenhagen
NCT02959762Phase 1/Phase 2 (Phase 2)Oct 1, 2016Augusta University
NCT02917525Phase 2Aug 1, 2016Maastricht University
NCT02876354Phase 4Aug 1, 2016Saint-Joseph University
NCT02870829Phase 2Jul 1, 2016Government of Singapore, National University of Singapore, Nattopharma
NCT02839044Phase 2Jun 1, 2016Utrecht University
NCT02610933Phase 4Nov 1, 2015OLV Hospital, Aalst, Belgium, Onze Lieve Vrouw Hospital
NCT02404519N/AJun 1, 2015Maastricht University
Showing 20 of 44 trials
Page 1 / 3

Organizations

Research & Development (41)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Maastricht UniversityAcademic/Hospital131322007
Augusta UniversityAcademic/Hospital5412013
NattopharmaFor profit4012013
Omicron PharmaceuticalsFor profit3022015
Lebanese American UniversityAcademic/Hospital2222015
OLV Hospital, Aalst, BelgiumAcademic/Hospital2022011
Onze Lieve Vrouw HospitalAcademic/Hospital2222011
Tufts UniversityAcademic/Hospital2012013
University of Alabama, BirminghamAcademic/Hospital2012013
University of CopenhagenAcademic/Hospital2222016
University of Southern DenmarkAcademic/Hospital2222018
Utrecht UniversityAcademic/Hospital2222007
Yale UniversityAcademic/Hospital2012013
Aarhus UniversityAcademic/Hospital1112013
Ain Shams UniversityAcademic/Hospital1112025
AZ Sint-JanAcademic/Hospital1012011
Cairo UniversityAcademic/Hospital1112024
Catholic University of SaltaAcademic/Hospital1112016
Changhua Christian HospitalAcademic/Hospital1112011
DaniscoFor profit1112012
41 organizations
Page 1 / 3