olive

Botanicalapproved

Approved

Oct 3, 2013

The olive, is a species of subtropical evergreen tree in the family Oleaceae. Originating in Asia Minor, it is abundant throughout the Mediterranean Basin, with wild subspecies in Africa and western Asia; modern cultivars are traced primarily to the Near East, Aegean Sea, and Strait of Gibraltar. The olive is the type species for its genus, Olea, and lends its name to the Oleaceae plant family, which includes lilac, jasmine, forsythia, and ash. The olive fruit is classed botanically as a drupe, similar in structure and function to the cherry or peach. The term oil—now used to describe any viscous water-insoluble liquid—was once synonymous with olive oil, the liquid fat derived from olives. — Wikipedia

Clinical trial activity

194 trials · 247 clinical orgs · 2 marketing orgs

Phase 1
11
Phase 2
24
Phase 3
14
Phase 4
15

Earliest trial started Nov 1, 1989 (NCT01353807)

Timeline

1800s

  1. Jan 1, 1800

    Evidence of US Marketing

1990s

  1. Jan 1, 1999

    Earliest Phase 3 Sponsor(trial)

2000s

  1. Jan 1, 2006

    Earliest Phase 1 Sponsor(trial)

  2. Jan 1, 2008

    Earliest Phase 2 Sponsor(trial)

2010s

  1. Oct 3, 2013

    Baxalta — Earliest FDA Approval

  2. Oct 3, 2013

    Baxalta — NDA Secondary Org

  3. Oct 3, 2013

    Baxalta — NDA Organization

  4. Jul 13, 2016

    Fresenius — NDA Secondary Org

Indications

Studied for

Mechanism of action

  • Unspecified targetSupplementation

    supplementation

Combination products

Approval history

  • approvedPriority reviewOct 3, 2013
  • approvedPriority reviewJan 1, 1800

Chemistry & pharmacology

Chirality
Single Stereoisomer
Inorganic
No
Polymer
No
Delivery
Parenteral
Availability
Prescription Only

Oral

No

Parenteral

Yes

Topical

No

Sources

Also known as

  • olive extract
  • olive leaf extract
  • olive oil
  • olive oil
  • olive oil
  • olive oil
  • olive polyphenol

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT06880939N/AJul 15, 2025Qingdao University, Shandong Provincial Hospital, Shandong University
NCT07008586N/AJul 1, 2025Anglia Ruskin University, Antonio e Bandino Lo Franco Soc. Agr. Sempl.
NCT06990282Phase 2Jul 1, 2025Fayoum University
NCT07210099N/AMay 30, 2025Anglia Ruskin University
NCT07127705N/AMay 21, 2025Natural Immune Systems Inc
NCT06971445N/AMay 14, 2025Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes
NCT06880926Phase 2Apr 1, 2025Shandong University
NCT07197073N/AFeb 25, 2025Alexandria University
NCT06737484N/AFeb 3, 2025Inonu University, Kahramanmaras Sutcu Imam University
NCT06723886N/AJan 15, 2025Government of Spain, Universidad Complutense de Madrid
NCT06570889Phase 3Nov 30, 2024University of Copenhagen
NCT06983145N/ANov 20, 2024University of the Aegean
NCT06567951N/ASep 10, 2024Universidad de los Andes, Universidad San Sebastián
NCT07144488N/ASep 1, 2024Apostolos Loukas Medical Centre Cyprus, University of Athens, University of Crete, Yale University
NCT06285682N/AFeb 3, 2024Anglia Ruskin University
NCT06621966N/AJan 10, 2024RAK Medical and Health Sciences University
NCT06972134N/ADec 15, 2023Duhok University
NCT06070311N/AOct 31, 2023Assiut University
NCT06072625N/AOct 1, 2023Uludag University
NCT06006663Phase 2/Phase 3 (Phase 3)Aug 26, 2023Tanta University
Showing 20 of 194 trials
Page 1 / 10

Organizations

Research & Development (247)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Government of SpainGovernment10322009
BASFFor profit4022015
Northumbria UniversityAcademic/Hospital4412016
University of CopenhagenAcademic/Hospital4321990
University of GranadaAcademic/Hospital4322020
University of ReadingAcademic/Hospital4412011
Ain Shams UniversityAcademic/Hospital3232022
Anglia Ruskin UniversityAcademic/Hospital3312024
Auburn UniversityAcademic/Hospital3312017
Centre for Fetal Programming, DenmarkAcademic/Hospital3211989
NestleFor profit3212020
The University of Texas, DallasAcademic/Hospital3322010
Universidad Complutense de MadridAcademic/Hospital3312018
University of AthensAcademic/Hospital3012018
University of Sao PauloAcademic/Hospital3232010
Yale UniversityAcademic/Hospital3212019
Zhejiang UniversityAcademic/Hospital3312020
Andalusian Health ServiceAcademic/Hospital2022021
Antonio e Bandino Lo Franco Soc. Agr. Sempl.Academic/Hospital2012021
Ardabil University of Medical SciencesAcademic/Hospital2212008
247 organizations
Page 1 / 13

Marketing (3)

OrganizationOrg typeRelationshipDate
BaxaltaFor profitNDA2Oct 3, 2013
BaxaltaFor profitNDAOct 3, 2013
FreseniusFor profitNDA2Jul 13, 2016