calcium
Small moleculeapproved
Approved
Apr 30, 1974
Calcium iodide (chemical formula CaI2) is the ionic compound of calcium and iodine, used in cat food as a source of iodine This colourless deliquescent solid is a salt that is highly soluble in water. Calcium iodide properties are similar to those for related salts, such as calcium chloride. Calcium iodide is also used in photography. — NCATS
Clinical trial activity
280 trials · 316 clinical orgs · 20 marketing orgs
Phase 1
29
Phase 2
95
Phase 3
58
Phase 4
47
Earliest trial started Mar 1, 1991 (NCT00000534)
Timeline
1970s
- Apr 30, 1974
Earliest FDA Approval
- Apr 30, 1974
General Electric — NDA Secondary Org
1990s
2000s
- Jan 1, 2004
Earliest Phase 1 Sponsor(trial)
- Jan 30, 2008
Hikma — Marketing Organization
- Jan 30, 2008
West-Ward Pharmaceutical — Marketing Organization
- Nov 24, 2008
Cypress Pharmaceutical — Marketing Organization
2010s
- Apr 13, 2011
Paddock Laboratories — Marketing Organization
- Apr 13, 2011
Padagis Us — Marketing Organization
- Feb 5, 2013
Chartwell Pharmaceuticals — Marketing Organization
- Feb 7, 2013
Invagen Pharms — Marketing Organization
- Oct 6, 2014
Amneal Pharmaceuticals — Marketing Organization
- Jan 22, 2015
Heritage Pharma — Marketing Organization
- Jan 22, 2015
Emcure — Marketing Organization
- Jul 9, 2015
Lupin — Marketing Organization
- Oct 26, 2015
Nostrum Laboratories — Marketing Organization
- Jul 26, 2016
Lotus Pharmaceutical — Marketing Organization
- Jul 26, 2016
Alvogen — Marketing Organization
2020s
- Feb 21, 2020
Suven Life Sciences Limited — Marketing Organization
- Jul 21, 2020
Jazz Pharmaceuticals — NDA Secondary Org
- Mar 13, 2023
Square Pharmaceuticals — Marketing Organization
Indications
Studied for
- Accidental Falls · Phase 3
- Acupuncture · Phase 2
- Adenocarcinoma · Phase 2
- Adenomatous Polyps · Phase 3
- Aging · Phase 2
- Alveolar Bone Loss · Phase 2
- Arteriosclerosis · Phase 4
- Arthralgia · Phase 1/Phase 2
- Arthritis, Juvenile · Phase 3
- Arthritis, Rheumatoid · Phase 4
- Atrial Fibrillation · Phase 4
- Bariatric Surgery · Phase 2/Phase 3
- Bipolar Disorder · Phase 2
- Bone Diseases · Phase 3
- Bone Diseases, Metabolic · Phase 4
- Brain Death · Phase 3
- Brain Mapping · Phase 2/Phase 3
- Breast Density · Phase 1
- Breast Diseases · Phase 2
- Breast Neoplasms · Phase 3
- Burns · Phase 1
- Calcinosis · Phase 4
- Carcinoma, Non-Small-Cell Lung · Phase 4
- Carcinoma, Transitional Cell · Phase 2
- Cardiovascular Diseases · Phase 4
- Chronic Kidney Disease-Mineral and Bone Disorder · Phase 4
- Cognition Disorders · Phase 2/Phase 3
- Colles' Fracture · Phase 4
- Colonic Neoplasms · Phase 3
- Colorectal Neoplasms · Phase 3
- Coronary Disease · Phase 3
- Cystic Fibrosis · Phase 1
- Deficiency Diseases · Phase 1
- Delivery, Obstetric · Phase 3
- Dental Caries · Early Phase 1
- Diabetes Mellitus · Phase 4
- Diabetes Mellitus, Type 2 · Phase 4
- Dialysis · Phase 4
- Diarrhea · Phase 1/Phase 2
- Diet · Phase 4
- Drug-Related Side Effects and Adverse Reactions · Phase 2
- Dyslipidemias · Phase 4
- Eclampsia · Phase 3
- Endothelium · Phase 4
- Enteral Nutrition · Phase 4
- Exercise · Phase 2
- Femoral Neck Fractures · Phase 3
- Fractures, Bone · Phase 4
- Fractures, Stress · Phase 3
- Frailty · Phase 4
- General Surgery · Phase 2
- Giant Cell Tumor of Bone · Phase 2
- Giant Cell Tumors · Phase 2
- Glucocorticoids · Phase 2
- Glucose Intolerance · Phase 1/Phase 2
- Growth · Phase 1
- Headache · Phase 1/Phase 2
- Healthy Volunteers · Phase 2/Phase 3
- Heart Arrest · Phase 2/Phase 3
- Heart Diseases · Phase 3
- Heart Failure · Phase 3
- HELLP Syndrome · Phase 3
- HIV · Phase 4
- HIV Infections · Phase 4
- Hypercalcemia · Phase 2
- Hypercholesterolemia · Phase 4
- Hyperparathyroidism · Phase 2
- Hyperparathyroidism, Primary · Phase 4
- Hyperparathyroidism, Secondary · Phase 4
- Hyperphosphatemia · Phase 3
- Hyperpigmentation · Phase 1/Phase 2
- Hypertension · Phase 4
- Hypertension, Pregnancy-Induced · Phase 4
- Hypertrophy, Left Ventricular · Phase 4
- Hypocalcemia · Phase 4
- Hypoparathyroidism · Phase 2
- Hypotension · Phase 2
- Hypothyroidism · Phase 2
- Infant, Low Birth Weight · Phase 3
- Infant, Premature, Diseases · Phase 2
- Infertility · Phase 2
- Infertility, Male · Phase 2/Phase 3
- Insulin Resistance · Phase 4
- Kidney Diseases · Phase 4
- Kidney Neoplasms · Phase 2
- Leukemia · Phase 3
- Lung Neoplasms · Phase 3
- Lupus Erythematosus, Systemic · Phase 4
- Lymphoma · Phase 3
- Malnutrition · Phase 1
- Menstruation Disturbances · Phase 2
- Metabolic Syndrome · Phase 1/Phase 2
- Metabolism · Phase 2
- Multiple Myeloma · Phase 3
- Multiple Sclerosis · Phase 3
- Musculoskeletal Diseases · Early Phase 1
- Myelodysplastic Syndromes · Phase 2
- Myocardial Ischemia · Phase 3
- Neoplasm Metastasis · Phase 4
- Neoplasms · Phase 3
- Obesity · Phase 3
- Obstetric Labor, Premature · Phase 3
- Osteitis Deformans · Phase 3
- Osteoarthritis · Phase 2
- Osteogenesis Imperfecta · Phase 2
- Osteoporosis · Phase 4
- Osteoporosis, Postmenopausal · Phase 4
- Osteoporotic Fractures · Phase 4
- Ovarian Hyperstimulation Syndrome · Phase 3
- Ovarian Neoplasms · Phase 2
- Ovulation Induction · Phase 3
- Paget Disease, Extramammary · Phase 4
- Pain · Phase 3
- Pancreatic Neoplasms · Phase 2
- Parkinson Disease · Phase 2
- Perinatal Death · Phase 3
- Periodontitis · Phase 1
- Peritoneal Dialysis · Phase 3
- Polycystic Ovary Syndrome · Phase 2
- Postmenopause · Phase 4
- Pre-Eclampsia · Phase 4
- Pregnancy · Phase 3
- Pregnancy Complications · Phase 3
- Prostatic Neoplasms · Phase 3
- Pulmonary Disease, Chronic Obstructive · Phase 1
- Recurrence · Phase 2
- Renal Insufficiency · Phase 3
- Renal Insufficiency, Chronic · Phase 4
- Scoliosis · Phase 3
- Spinal Cord Injuries · Phase 2
- Spinal Injuries · Phase 4
- Sprains and Strains · Phase 3
- Tendinopathy · Phase 3
- Thyroiditis, Autoimmune · Phase 2
- Thyroid Neoplasms · Phase 2
- Tuberculosis · Phase 4
- Tuberculosis, Pulmonary · Phase 4
- Ureteral Neoplasms · Phase 2
- Urinary Bladder Neoplasms · Phase 2
- Vascular Diseases · Phase 4
- Vascular Stiffness · Phase 2
- Vitamin D · Phase 4
- Vitamin D Deficiency · Phase 4
Mechanism of action
- PhosphateSEQUESTERING AGENT
Phosphate sequestering agent
Combination products
isopaque
with meglumine, metrizoic acid
procalamine
with glycerin, potassium chloride, phosphoric acid, sodium acetate, amino acids, sodium chloride, magnesium
Approval history
- approvedApr 30, 1974
Chemistry & pharmacology
Loading structure…
SMILES
[Ca++]- Mol. weight
- 40.078 g/mol
- Chirality
- Achiral Molecule
- Inorganic
- Yes
- Polymer
- No
- Delivery
- Parenteral
- Availability
- Discontinued
Oral
No
Parenteral
Yes
Topical
No
Sources
- WikipediaCalcium ↗
- NCATS2M83C4R6ZB ↗
- ChEMBLCHEMBL1200800 ↗
- ChEMBLCHEMBL5072826 ↗
- WikipediaCalcium acetate ↗
- ChEMBLCHEMBL1200496 ↗
- ChEMBLCHEMBL2146121 ↗
Also known as
- acetate of lime
- acetate of lime
- acetic acid calcium salt
- acetic acid, calcium salt
- acetic acid, calcium salt (2:1)
- brown acetate of lime
- brown acetate of lime
- calcium
- calcium
- calcium
- calcium
- calcium acetate
- calcium acetate
- calcium acetate
- calcium acetate
- calcium acetate
- calcium acetate
- calcium acetate
- calcium acetate
- calcium acetate
- calcium acetate and magnesium carbonate
- calcium acetate anhydrous
- calcium diacetate
- calcium dialysate
- calcium ethanoate
- calcium ethanoate
- calcium(ii) acetate
- calcium(ii) acetate
- ca(oac)2
- ca(oac)2
- e263
- e263
- eliphos
- eliphos
- everose
- gray acetate of lime
- gray acetate of lime
- lime acetate
- lime acetate
- lime pyrolignite
- lime pyrolignite
- phosex
- phoslo
- phoslo
- phoslo
- phoslo gelcaps
- phoslo gelcaps
- phoslyra
- phoslyra
- renacet
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07120997 | N/A | Sep 30, 2025 | California Dried Plum Board, Pennsylvania State University, United States Department of Agriculture, University of Georgia |
| NCT06930391 | N/A | Sep 15, 2025 | Icahn School of Medicine at Mount Sinai |
| NCT07013656 | N/A | Jun 28, 2025 | University of Adelaide |
| NCT06942195 | N/A | May 28, 2025 | University of Adelaide |
| NCT05933499 | Phase 2 | Oct 1, 2023 | Harvard University |
| NCT05612984 | Phase 3 | Sep 30, 2023 | Aga Khan University, Columbia University, Johns Hopkins University, Thomas Jefferson University, Zvitambo Institute for Maternal and Child Health Research |
| NCT06022237 | N/A | Sep 1, 2023 | Institute of Liver and Biliary Sciences, India |
| NCT05884372 | Phase 4 | Aug 31, 2023 | Chugai, Jiao Tong University |
| NCT05860062 | N/A | Apr 18, 2023 | Instituto Mexicano del Seguro Social |
| NCT05795504 | N/A | Mar 1, 2023 | Cairo University |
| NCT05691959 | Phase 2 | Jan 26, 2023 | Ascension Health |
| NCT06494007 | Phase 4 | Jan 1, 2023 | Haseki Training and Research Hospital |
| NCT05661942 | Phase 4 | Nov 30, 2022 | University of Wisconsin, Wake Forest University |
| NCT05630768 | Phase 4 | Nov 30, 2022 | Dong-A Pharmaceutical |
| NCT05523609 | Phase 2/Phase 3 (Phase 3) | Nov 1, 2022 | Tanta University |
| NCT05424263 | Phase 2 | Sep 29, 2022 | University of Colorado, University of Colorado, Denver |
| NCT06087068 | Phase 2 | Aug 1, 2022 | Chinese Academy of Medical Sciences |
| NCT05421819 | N/A | Jun 15, 2022 | National Hellenic Research Foundation, University of Athens |
| NCT05392790 | N/A | May 23, 2022 | Cairo University |
| NCT05381168 | N/A | May 20, 2022 | Chulalongkorn University |
Showing 20 of 280 trials
Page 1 / 14
Organizations
Research & Development (316)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| National Institutes of Health (NIH) | Government | 13 | 3 | 4 | 1991 |
| Novartis | For profit | 10 | 7 | 4 | 2000 |
| Eli Lilly | For profit | 9 | 7 | 4 | 1996 |
| University of Copenhagen | Academic/Hospital | 8 | 8 | 3 | 2008 |
| Amgen | For profit | 6 | 2 | 4 | 2006 |
| National Institute on Aging (NIA) | Government | 6 | 0 | 3 | 1999 |
| Cairo University | Academic/Hospital | 5 | 5 | 3 | 2011 |
| Fresenius | For profit | 5 | 3 | 4 | 2005 |
| Merck | For profit | 5 | 5 | 3 | 2008 |
| National Cancer Institute (NCI) | Government | 5 | 1 | 2 | 1999 |
| National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) | Government | 5 | 0 | 2 | 1991 |
| Pfizer | For profit | 5 | 3 | 2 | 2007 |
| University of Pittsburgh | Academic/Hospital | 5 | 4 | 3 | 2007 |
| Aarhus University | Academic/Hospital | 4 | 3 | 3 | 2008 |
| Creighton University | Academic/Hospital | 4 | 4 | 3 | 1995 |
| GlaxoSmithKline | For profit | 4 | 1 | 3 | 2000 |
| Harvard University | Academic/Hospital | 4 | 3 | 3 | 2004 |
| Jiao Tong University | Academic/Hospital | 4 | 4 | 3 | 2013 |
| Johns Hopkins University | Academic/Hospital | 4 | 2 | 3 | 2011 |
| Northumbria University | Academic/Hospital | 4 | 4 | 1 | 2011 |
316 organizations
Page 1 / 16
Marketing (25)
| Organization | Org type | Relationship | Date |
|---|---|---|---|
| Alvogen | For profit | MKTG | Jul 26, 2016 |
| Amneal Pharmaceuticals | For profit | MKTG | Oct 6, 2014 |
| B. Braun | For profit | MKTG | May 6, 1982 |
| B. Braun | For profit | NDA2 | May 6, 1982 |
| Chartwell Pharmaceuticals | For profit | MKTG | Feb 5, 2013 |
| Chartwell Pharmaceuticals | For profit | SYN | Jun 1, 2012 |
| Cypress Pharmaceutical | For profit | MKTG | Nov 24, 2008 |
| Emcure | For profit | MKTG | Jan 22, 2015 |
| Fresenius | For profit | NDA2 | Dec 10, 1990 |
| Fresenius | For profit | NDA | Jan 1, 1990 |
| General Electric | For profit | NDA2 | Apr 30, 1974 |
| Heritage Pharma | For profit | MKTG | Jan 22, 2015 |
| Hikma | For profit | MKTG | Jan 30, 2008 |
| Hikma | For profit | MKTG | Jan 30, 2008 |
| Invagen Pharms | For profit | MKTG | Feb 7, 2013 |
| Jazz Pharmaceuticals | For profit | NDA2 | Jul 21, 2020 |
| Lotus Pharmaceutical | For profit | MKTG | Jul 26, 2016 |
| Lupin | For profit | MKTG | Jul 9, 2015 |
| Nostrum Laboratories | For profit | MKTG | Oct 26, 2015 |
| Padagis Us | For profit | MKTG | Apr 13, 2011 |
| Paddock Laboratories | For profit | MKTG | Apr 13, 2011 |
| Square Pharmaceuticals | For profit | MKTG | Mar 13, 2023 |
| Suven Life Sciences Limited | For profit | MKTG | Feb 21, 2020 |
| Suven Life Sciences Limited | For profit | SYN | Feb 21, 2020 |
| West-Ward Pharmaceutical | For profit | MKTG | Jan 30, 2008 |