← All indications
Malaria
A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.
Subtype terms (4)
More specific conditions that are subtypes of Malaria in the MeSH hierarchy.
- Malaria, Avian
- Malaria, Cerebral
8 drugs (7 approved, 1 experimental)
- Malaria, Falciparum
132 drugs (44 approved, 88 experimental)
- Malaria, Vivax
38 drugs (17 approved, 21 experimental)
Drugs by status
Approved for this indication (21)
Phase 4 trials (18)
Phase 3 trials (47)
- efavirenz
- vitamin e
- plasmodium falciparum malaria vaccine
- dehydroepiandrosterone
- prednisone
- fosmidomycin
- gsk 257049
- tenofovir
- ritonavir
- hydroxyurea
- inactivated rabies vaccine
- lamivudine
- meningococcal (groups A, C, Y, W) CRM197 conjugate vaccine
- nevirapine
- hepatitis b vaccine (recombinant)
- rabies vaccine (purified chick embryo cell vaccine)
- lopinavir
- s-1
- emtricitabine
- yellow fever vaccine 17d strain
- attenuated measles vaccine - Edmonston strain
- inactivated influenza vaccine
- Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed and Inactivated Poliovirus Vaccine
- live oral poliovirus type 1, 2 and 3
- measles-rubella vaccine
- 10-valent Pneumococcal Conjugate Vaccine
- zinc dichloride
- abamectin
- fenperoximate
- gimeracil
- +17 more
Phase 2 trials (74)
- aminolevulinic acid
- aq-13
- artefenomel
- cetirizine
- chad63 me-trap
- ad35.cs.01
- cyclizine lactate
- ibuprofen
- dsm265
- ferroquine
- cipargamin
- Ganaplacide
- mepolizumab
- mmv390048
- momordica charantia
- mva me-trap
- nitric oxide
- aluminum hydroxide
- pneumococcal 13-valent conjugate vaccine
- methylene blue
- rouvax
- typhoid vi polysaccharide vaccine
- sar97276a
- tetracthib
- tritanrix-hepb
- hepatitis a vaccine, inactivated
- adch63 ama1
- adenovirus-vectored malaria vaccines encoding plasmodium falciparum circumsporozoite protein and apical membrane antigen 1
- ama1-c1
- as01
- +44 more
Phase 1 trials (70)
- metformin
- argemone mexicana
- gap3ko
- naltrexone
- dolutegravir
- n-tert-butylisoquine
- rosuvastatin
- p218
- repaglinide
- sitagliptin
- ruxolitinib
- (+)-sj000557733
- gla-se
- itraconazole
- ama1
- chad63 pvdbp
- chad63 rh5
- fp9 cs
- gla-lsq
- gmz2
- hdcrv
- malaria transmission-blocking pfs25-pfs25 conjugate vaccine
- msp3
- msp3 vaccine
- mva cs
- mva pvdbp
- mva rh5
- nmrc-m3v-ad-pfca
- p27a vaccine candidate
- pamvac
- +40 more
Organizations
Organization Involved with Phase 4 Indications (166)
- Sanofi
- Institut Pasteur
- Mepha Ltd.
- Dafra Pharma
- Epicentre
- Bandim Health Project
- FHI 360
- German Research Foundation
- Malaria Consortium
- Malaria Consortium, UK
- Medicines for Malaria Venture
- National Institutes of Health (NIH)
- Global Emerging Infections Surveillance and Response System
- Medical Research Council
- National Heart, Lung, and Blood Institute (NHLBI)
- National Institute for Medical Research, Tanzania
- National Institute of Allergy and Infectious Diseases (NIAID)
- National Institute of Malariology, Parasitology and Entomology, Vietnam
- Pan American Health Organization
- United States Army
- United States Navy
- Centre for Global Health Research, Ghana
- World Health Organization
- Centre Muraz
- Centre Hospitalier Universitaire Vaudois
- Albert Schweitzer Hospital
- Armauer Hansen Research Institute, Ethiopia
- Boston University
- Cheikh Anta Diop University, Senegal
- University of London
- +136 more
Organization Involved with Phase 3 Indications (108)
- Pfizer
- Sanofi-Synthelabo
- Proto Pharma Ltd
- Malaria Consortium, Uganda
- Tropical Diseases Research Centre, Zambia
- International Atomic Energy Agency
- KEMRI-Wellcome Trust Collaborative Research Program
- Fundação de Medicina Tropical Dr. Heitor Vieira Dourado
- Addis Ababa University
- Cameroon Baptist Convention Health
- Centro Internacional de Entrenamiento e Investigaciones Médicas
- INDEPTH Network
- Indiana University
- Johns Hopkins University
- Lihir Medical Centre
- Mbarara University of Science and Technology
- Michigan State University
- Myanmar Oxford Clinical Research Unit
- Royal Tropical Institute
- Tropical Medicine Research Institute
- University of Ghana
- University of Maryland
- University of Tampere
- University of Toronto
- University of Bamako
- University of Bordeaux
- Centre de Recherche Médicale de Lambaréné
- Colorado State University
- Department of Medical Research, Lower Myanmar
- Ethiopian Public Health Institute
- +78 more
Organization Involved with Phase 2 Indications (65)
- Zentopharm GmbH
- SmithKline Beecham
- Crucell
- HuLow
- Immtech Pharmaceuticals, Inc
- Leadiant Biosciences, Inc.
- Modus Therapeutics AB
- Parexel
- Sanaria Inc.
- Vac4All
- Jomaa Pharma GmbH
- Pevion Biotech Ltd
- African Malaria Network Trust
- National Institute of Neurological Disorders and Stroke (NINDS)
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Harvard University
- European Malaria Vaccine Initiative
- University of Washington
- Malaria Vaccine and Drug Development Center
- Marquette University
- Policlinique Médicale Universitaire
- Thammasat University
- Tulane University
- University of Rochester
- University of Sydney
- Purdue University
- University of Utah
- Worcester Polytechnic Institute
- University of Vienna
- Hue University
- +35 more
Organization Involved with Phase 1 Indications (65)
- Actelion
- Eisai
- ViiV Healthcare
- Merck KGaA
- FGK Clinical Research GmbH
- Immune Design
- Mymetics Corporation
- Shanghai Wanxing Bio-Pharmaceutical Co. Ltd.
- National Cancer Institute (NCI)
- National Center for Complementary and Integrative Health (NCCIH)
- National Institute of Dental and Craniofacial Research (NIDCR)
- Deakin University
- Institut National de la Santé Et de la Recherche Médicale, France
- New York University
- RTI International
- Universidad Autonoma de Madrid
- University of Ibadan
- University of South Florida
- University of Bern
- Royal College of Surgeons, Ireland
- University of Cambridge
- Celerion
- Hammersmith Medicines Research
- Nucleus Network Ltd
- Covance
- SGS Life Sciences
- Jiao Tong University
- Quotient
- Bagamoyo Research and Training Center
- Richmond Pharmacology
- +35 more
Organization Involved with Other Experimental Indications (44)
- Alliance for International Medical Action
- Save the Children
- ZonMw: The Netherlands Organisation for Health Research and Development
- Medical Research Council, South Africa
- Swiss Federal Institute of Technology
- Armed Forces Research Institute of Medical Sciences, Thailand
- Aarhus University
- Case Western Reserve University
- Gadjah Mada University
- Sheffield Hallam University
- Universidade Nova de Lisboa
- University of Manchester
- University of Ottawa
- Noguchi Memorial Institute for Medical Research
- University of California, Irvine
- The Alliance for International Medical Action (ALIMA)
- John Snow, Inc.
- National Malaria Research and Training Center, Burkina Faso
- Research Institute for Tropical Medicine, Alabang, Muntinlupa, Metro Manila, Philippines
- National Malaria Control Programme Cambodia
- National Insitute for Medical Research, Mwanza, Tanzania
- Kumasi University
- RITM, DOH, Philippines
- Laboratoire National de Sante Publique
- Uganda AIDS Commission
- Department of Veteran Affairs
- Programme national de lutte contre le paludisme, Mali
- Federal Ministry of Health, Nigeria
- Pharmacy Board of Sierra Leone
- Family Health International, Cambodia
- +14 more