abamectin
Abamectin (also called avermectin B1) is a widely used insecticide and anthelmintic. Abamectin, is a member of the avermectin family and is a natural fermentation product of soil dwelling actinomycete Streptomyces avermitilis. Abamectin differs from ivermectin, the popular member of the avermectin family, by a double bond between carbons 22 and 23. Fermentation of Streptomyces avermitilis yields eight closely related avermectin homologs, with the B1a and B1b forms comprising the majority of the fermentation. The non-proprietary name, abamectin, refers to a mixture of B1a (~80%) and B1b (~20%). Out of all the avermectins, abamectin is the only one that is used both in agriculture and pharmaceuticals. — Wikipedia
Clinical trial activity
1 trials · 6 clinical orgs · 0 marketing orgs
Earliest trial started Nov 9, 2015 (NCT02533336)
Timeline
2010s
- Jan 1, 2015
Earliest Phase 3 Sponsor(trial)
Indications
Studied for
Mechanism of action
- Unspecified targetUnclear
unclear
Chemistry & pharmacology
SMILES
CC[C@H](C)[C@H]1O[C@]2(C=C[C@@H]1C)C[C@@H]1C[C@@H](C/C=C(\C)[C@@H](O[C@H]3C[C@H](OC)[C@@H](O[C@H]4C[C@H](OC)[C@@H](O)[C@H](C)O4)[C@H](C)O3)[C@@H](C)/C=C/C=C3\CO[C@@H]4[C@H](O)C(C)=C[C@@H](C(=O)O1)[C@]34O)O2.CO[C@H]1C[C@H](O[C@H]2[C@H](C)O[C@@H](O[C@@H]3/C(C)=C/C[C@@H]4C[C@@H](C[C@]5(C=C[C@H](C)[C@@H](C(C)C)O5)O4)OC(=O)[C@@H]4C=C(C)[C@@H](O)[C@H]5OC/C(=C\C=C\[C@@H]3C)[C@]54O)C[C@@H]2OC)O[C@@H](C)[C@@H]1O- Mol. weight
- 1732.15 g/mol
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaAbamectin ↗
- ChEMBLCHEMBL3215298 ↗
Also known as
- abamectin
- abamectin
- abamectin
- abamectin
- avermectin b1
- endecto
- enzec
- enzek
- l 676
- l-676
- l-676,863
- mk-0936
- mk-0936
- mk 936
- mk-936
- parafoil
- vertimec 18ec
- vertimil
- zectin
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT02533336 | Phase 3 | Nov 9, 2015 | Brandeis University, Centers for Disease Control and Prevention (CDC), Kilimanjaro Christian Medical College, Tanzania, National Institute for Medical Research, Tanzania, United States Agency for International Development, University of London |
Organizations
Research & Development (6)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Brandeis University | Academic/Hospital | 1 | 0 | 1 | 2015 |
| Centers for Disease Control and Prevention (CDC) | Government | 1 | 0 | 1 | 2015 |
| Kilimanjaro Christian Medical College, Tanzania | Academic/Hospital | 1 | 0 | 1 | 2015 |
| National Institute for Medical Research, Tanzania | Government | 1 | 1 | 1 | 2015 |
| United States Agency for International Development | Government | 1 | 0 | 1 | 2015 |
| University of London | Academic/Hospital | 1 | 0 | 1 | 2015 |