yellow fever vaccine 17d strain
Approved
May 22, 1953
Yellow fever vaccine is a vaccine that protects against yellow fever. Yellow fever is a viral infection that occurs in Africa and South America. Most people begin to develop immunity within ten days of vaccination and are 99% protected within one month, and this appears to be lifelong. The vaccine can be used to control outbreaks of disease. It is given either by injection into a muscle or just under the skin. — Wikipedia
Clinical trial activity
47 trials · 53 clinical orgs · 1 marketing orgs
Earliest trial started Jul 1, 2004 (NCT00982137)
Timeline
1930s
- Jul 1, 1935
Evidence of US Marketing
1950s
- May 22, 1953
Earliest FDA Approval
1990s
- Dec 9, 1999
Sanofi-Aventis — First NDA Organization
- Dec 9, 1999
Sanofi-Aventis — NDA Secondary Org
- Dec 9, 1999
Sanofi-Aventis — NDA Organization
2010s
- Jan 1, 2011
Earliest Phase 3 Sponsor(trial)
Indications
Approved for
Studied for
- Communicable Diseases · Phase 2
- Dengue · Phase 3
- Dermatitis, Atopic · Phase 1/Phase 2
- Drug-Related Side Effects and Adverse Reactions · Phase 4
- Encephalitis, Japanese · Phase 2
- Healthy Volunteers · Phase 4
- HIV Infections · Phase 4
- Immunity · Phase 4
- Immunization · Phase 1/Phase 2
- Malaria · Phase 3
- Malaria, Falciparum · Early Phase 1
- Malaria Vaccines · Phase 3
- Measles · Phase 3
- Measles-Mumps-Rubella Vaccine · Phase 3
- Rotavirus Infections · Phase 4
- Rubella · Phase 3
- Salmonella Infections · Phase 2
- Severe Dengue · Phase 2
- Streptococcal Infections · Phase 2
- Vaccines · Phase 4
- Viremia · Phase 1
- Virus Diseases · Phase 2
- Yellow Fever · Phase 4
- Yellow Fever Vaccine · Phase 4
- Zika Virus Infection · Phase 1
Mechanism of action
- Unspecified targetOTHER
Biological vaccine - induces immune response
- Yellow fever virusImmunity, active
Yellow fever virus immunity, active
Approval history
- approvedMay 22, 1953
- approvedJul 1, 1935
Chemistry & pharmacology
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaYellow fever vaccine ↗
- NCATSPY4EET359T ↗
- ChEMBLCHEMBL2108816 ↗
Also known as
- flavivirus yellow fever virus 17d-204 whole
- inactivated yellow fever vaccine
- live attenuated yellow fever vaccine
- mva-bn yellow fever vaccine
- stamaril
- yellow fever, live attenuated
- yellow fever, live attenuated
- yellow fever vaccine
- yellow fever vaccine
- yellow fever vaccine
- yellow fever vaccine
- yellow fever vaccine 17d strain
- yellow fever vaccine, live, 17d
- yellow fever virus 17d/tiantan live antigen
- yellow fever virus live antigen, a
- yellow fever virus strain 17d-204 live antigen
- yellow fever virus strain 17d-204 live (attenuated) antigen
- yellow fever virus strain 17d (live, attenuated)
- yellow fever virus vaccine
- yfv-17d
- yf-vax
- yf-vax
- yf-vax
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07222059 | Phase 3 | Oct 23, 2025 | Sanofi-Aventis |
| NCT07103148 | Phase 3 | Jul 11, 2025 | Sanofi |
| NCT06879327 | Phase 2 | May 30, 2025 | PATH, Pharmassist Ltd |
| NCT07002060 | Phase 3 | May 22, 2025 | Sanofi |
| NCT06815835 | Phase 3 | Apr 1, 2025 | International Center for Diarrheal Disease Research, Zydus Discovery DMCC |
| NCT06399003 | Phase 3 | Jun 28, 2024 | China National Biotec Group Co., Ltd |
| NCT06213506 | Phase 2 | Jan 15, 2024 | GlaxoSmithKline, Kwame Nkrumah University of Science and Technology |
| NCT06148025 | Phase 4 | Nov 30, 2023 | Flinders University, South Australian Health and Medical Research Institute, Telethon Kids Institute, University of Adelaide, University of Sydney |
| NCT05859490 | Phase 1/Phase 2 (Phase 2) | Aug 1, 2023 | Oregon Health and Science University |
| NCT05801978 | Phase 4 | Apr 11, 2023 | Defense Advanced Research Projects Agency, Emory University |
| NCT05901454 | N/A | Feb 17, 2023 | Leiden University |
| NCT05468606 | Early Phase 1 (Phase 1) | Jan 31, 2023 | Leiden University |
| NCT05568953 | Phase 2 | Oct 31, 2022 | Duke University, Singapore General Hospital |
| NCT05447377 | Phase 3 | Jul 30, 2022 | Serum Institute of India Pvt. Ltd. |
| NCT05421611 | Phase 3 | Jul 25, 2022 | Serum Institute of India Pvt. Ltd. |
| NCT05450770 | N/A | Jul 1, 2022 | Government of France, University of Paris |
| NCT05332197 | Phase 3 | May 16, 2022 | University of London |
| NCT05155579 | Phase 1 | Feb 28, 2022 | Malaria Research and Training Center, Bamako, Mali, University of Oxford |
| NCT05011123 | Phase 2 | Oct 7, 2021 | Sanofi, Sanofi-Aventis |
| NCT04942210 | Phase 2 | Jul 1, 2021 | Sanofi-Aventis |
Organizations
Research & Development (53)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Sanofi-Aventis | For profit | 6 | 4 | 3 | 2006 |
| Sanofi | For profit | 5 | 4 | 2 | 2004 |
| Emory University | Academic/Hospital | 4 | 4 | 3 | 2006 |
| GlaxoSmithKline | For profit | 4 | 4 | 2 | 2007 |
| National Institute of Allergy and Infectious Diseases (NIAID) | Government | 4 | 3 | 2 | 2008 |
| Centers for Disease Control and Prevention (CDC) | Government | 3 | 1 | 2 | 2006 |
| PATH | Academic/Hospital | 3 | 2 | 2 | 2011 |
| Epicentre | For profit | 2 | 1 | 1 | 2017 |
| Leiden University | Academic/Hospital | 2 | 2 | 2 | 2023 |
| Medical Research Council-UVRI Uganda Research Unit on AIDS | Academic/Hospital | 2 | 0 | 1 | 2018 |
| Oregon Health and Science University | Academic/Hospital | 2 | 1 | 1 | 2008 |
| Oswaldo Cruz Foundation | Academic/Hospital | 2 | 2 | 1 | 2016 |
| Serum Institute of India Pvt. Ltd. | For profit | 2 | 2 | 1 | 2022 |
| Singapore General Hospital | Academic/Hospital | 2 | 2 | 1 | 2017 |
| University of London | Academic/Hospital | 2 | 1 | 2 | 2011 |
| University of Oxford | Academic/Hospital | 2 | 2 | 2 | 2019 |
| University of Paris | Academic/Hospital | 2 | 0 | 2 | 2011 |
| Aarhus University | Academic/Hospital | 1 | 1 | 1 | 2019 |
| Centre for Vaccine Development, Mali | Academic/Hospital | 1 | 0 | 1 | 2014 |
| China National Biotec Group Co., Ltd | For profit | 1 | 1 | 1 | 2024 |
Marketing (2)
| Organization | Org type | Relationship | Date |
|---|---|---|---|
| Sanofi-Aventis | For profit | NDA2 | Dec 9, 1999 |
| Sanofi-Aventis | For profit | NDA | Dec 9, 1999 |