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artemisinin

Small moleculeexperimental

Artemisinin and its semisynthetic derivatives are a group of drugs used in the treatment of malaria due to Plasmodium falciparum. It was discovered in 1972 by Tu Youyou, who shared the 2015 Nobel Prize in Physiology or Medicine for her discovery. Artemisinin-based combination therapies (ACTs) have become standard treatment worldwide for P. falciparum malaria as well as malaria due to other species of Plasmodium. Artemisinin can be extracted from the herb Artemisia annua, which is used in traditional Chinese medicine. Alternatively, it can be prepared by a semi-synthetic method from a precursor compound that can be produced using a genetically engineered yeast, which is much more efficient than extraction from the plant. — Wikipedia

Clinical trial activity

25 trials · 41 clinical orgs · 0 marketing orgs

Phase 1
1
Phase 2
12
Phase 3
6
Phase 4
5

Earliest trial started Aug 31, 2008 (NCT00753506)

Timeline

2000s

  1. Jan 1, 2008

    Earliest Phase 3 Sponsor(trial)

  2. Jan 1, 2009

    Earliest Phase 2 Sponsor(trial)

2010s

  1. Jan 1, 2015

    Earliest Phase 1 Sponsor(trial)

Indications

Approved for

Studied for

Mechanism of action

  • Unspecified targetOTHER

    Unknown

Chemistry & pharmacology

Loading structure…

SMILES

C[C@@H]1CC[C@H]2[C@@H](C)C(=O)O[C@@H]3O[C@@]4(C)CC[C@@H]1[C@]32OO4
Mol. weight
282.34 g/mol
Lipinski Ro5
Pass
Rule of 3
No
Chirality
Single Stereoisomer
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

First in class

Sources

Also known as

  • arteannuin
  • arteannuin
  • artemef
  • artemisin
  • artemisin
  • artemisine
  • artemisinin
  • artemisinin
  • artemisinin
  • artemisinin
  • artemisinin
  • artemisinin
  • artemisinin
  • artemisinin
  • (+)-artemisinin
  • (+)-artemisinin
  • (+)-artemisinin
  • artemisinine
  • artemisinine
  • artemisinine
  • gnf-pf-5341
  • gnf-pf-5341
  • qinghaosu
  • quinghaosu
  • quing hau sau

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT06173206Phase 3Mar 15, 2024University of London
NCT06166498Phase 3Feb 15, 2024University of London
NCT06206564Phase 2Jan 12, 2024Anal Dysplasia Clinic MidWest, Frantz Medical
NCT06075264Phase 2Dec 6, 2023Frantz Medical, The Cleveland Clinic
NCT04802382Phase 3Jun 11, 2021MGC Pharmaceuticals
NCT04801017Phase 2Apr 30, 2021Oncotelic Inc.
NCT04428385N/AOct 31, 2020Clinton Health Access Initiative, USA, Duke University, Moi Univeristy, National Institute of Allergy and Infectious Diseases (NIAID)
NCT04428307N/AOct 31, 2020Clinton Health Access Initiative, USA, Duke University, Moi Univeristy, National Institute of Allergy and Infectious Diseases (NIAID)
NCT05004753Phase 4Sep 30, 2020Mateon Therapeutics, Windlas Healthcare
NCT04387240Phase 2Jun 30, 2020Princess Nourah Bint Abdulrahman University
NCT04382040Phase 2May 8, 2020MGC Pharmaceuticals
NCT04020653Phase 2Sep 6, 2019Neopharma, Parexel
NCT03951259Phase 2May 15, 2019Jiangsu ZuoYou Medicine Co., Ltd., Jiao Tong University
NCT04167566N/AJul 1, 2017Noguchi Memorial Institute for Medical Research, World Health Organization
NCT02653898Phase 4Jan 1, 2016Government of Cambodia, Government of Thailand, National Center for Parasitology, Entomology and Malaria Control
NCT02568098Phase 1Oct 1, 2015Mahidol University, University of Oxford
NCT02604966Phase 4Apr 1, 2015Institute of Tropical Medicine, Belgium, National Institute of Malariology, Parasitology and Entomology, Vietnam, University of Antwerp
NCT02118090Phase 4May 1, 2014Institut Pasteur, National Institute of Allergy and Infectious Diseases (NIAID)
NCT01930331Phase 4Sep 1, 2013Ifakara Health Institute
NCT01838902Phase 3Aug 1, 2013Medical Research Council, Medical Research Council, The Gambia
Showing 20 of 25 trials
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Organizations

Research & Development (41)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Government of ThailandGovernment3222012
National Institute of Allergy and Infectious Diseases (NIAID)Government3022014
University of LondonAcademic/Hospital3312009
Clinton Health Access Initiative, USAAcademic/Hospital2012020
Duke UniversityAcademic/Hospital2212020
Frantz MedicalFor profit2212023
MGC PharmaceuticalsFor profit2222020
Moi UniveristyAcademic/Hospital2012020
National Centre for Parasitology, Entomology and Malaria Control, CambodiaAcademic/Hospital2012012
Royal Cambodian Armed ForcesGovernment2012012
Stanley Medical Research InstituteAcademic/Hospital2022008
United States ArmyGovernment2012012
Anal Dysplasia Clinic MidWestAcademic/Hospital1012024
Armed Forces Research Institute of Medical Sciences, ThailandAcademic/Hospital1112012
BEIJING HOLLEY-COTEC PHARMACEUTICALS CO. LTD.For profit1012009
Department of Veteran AffairsGovernment1012012
Government of CambodiaGovernment1012016
Ifakara Health InstituteAcademic/Hospital1112013
Institute of Tropical Medicine, BelgiumAcademic/Hospital1012015
Institut PasteurAcademic/Hospital1112014
41 organizations
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