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zinc dichloride

Small moleculeapproved

Approved

Jul 29, 1955

Gluconic acid is a natural compound produced from glucose through a simple dehydrogenation reaction catalysed by glucose oxidase. Gluconic acid and its salts are used in the formulation of food, pharmaceutical and hygienic products. — NCATS

Clinical trial activity

109 trials · 142 clinical orgs · 18 marketing orgs

Phase 1
13
Phase 2
44
Phase 3
30
Phase 4
16

Earliest trial started Oct 1, 1993 (NCT00004338)

Timeline

1950s

  1. Jul 29, 1955

    Earliest FDA Approval

1980s

  1. Feb 22, 1980

    Armour & Company — Marketing Organization

  2. Feb 22, 1980

    Armour & Company — NDA Secondary Org

  3. Jun 26, 1986

    Hospira — NDA Secondary Org

  4. May 5, 1987

    Abraxis — NDA Secondary Org

1990s

  1. Jan 28, 1997

    Teva — First NDA Organization

  2. Jan 28, 1997

    Teva — NDA Secondary Org

  3. Jan 28, 1997

    Teva — NDA Organization

  4. Jan 28, 1997

    Eton Pharmaceuticals, Inc. — Marketing Organization

  5. Jan 1, 1999

    Earliest Phase 3 Sponsor(trial)

2000s

  1. Jan 1, 2003

    Earliest Phase 2 Sponsor(trial)

  2. Jan 1, 2005

    Earliest Phase 1 Sponsor(trial)

2010s

  1. Jul 18, 2019

    Sankyo — Marketing Organization

  2. Jul 18, 2019

    Daiichi Sankyo — NDA Secondary Org

2020s

  1. May 21, 2021

    Exela Pharma Sciences, LLC. — Marketing Organization

  2. May 3, 2022

    Gland Pharma Ltd — Marketing Organization

  3. May 3, 2022

    Fosun — Marketing Organization

  4. Dec 27, 2022

    Fresenius — Marketing Organization

  5. Aug 22, 2023

    Zydus Discovery DMCC — Marketing Organization

  6. Jun 10, 2024

    Apotex — Marketing Organization

  7. Jul 5, 2024

    Nivagen Pharmaceuticals Inc. — Marketing Organization

  8. Jul 17, 2024

    Somerset Pharmaceuticals — Marketing Organization

  9. Apr 14, 2025

    Apicore — Marketing Organization

  10. May 1, 2025

    Aspiro — Marketing Organization

  11. Jun 10, 2025

    STIRA — Marketing Organization

Indications

Approved for

Studied for

Mechanism of action

Combination products

Approval history

  • approvedJul 29, 1955

Chemistry & pharmacology

Loading structure…

SMILES

O.O.O=C([O-])[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.O=C([O-])[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.[Mg+2]
Mol. weight
450.63 g/mol
Lipinski Ro5
Pass
Rule of 3
Yes
Chirality
Single Stereoisomer
Inorganic
No
Polymer
No
Availability
Discontinued

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • almora
  • almora
  • anusol
  • anusol
  • bis(n-oxopyridine-2-thionato)zinc (ii)
  • boron gluconate
  • chelated zinc
  • curash
  • dan-gard
  • de-squaman
  • dextronic acid
  • dextronic acid
  • dextronic acid
  • dextronic acid
  • d-gluconate
  • d-gluconic acid
  • d-gluconic acid
  • d-gluconic acid
  • d-gluconic acid
  • d-gluconic acid
  • d-gluconic acid, monosodium salt
  • dr.elsoms
  • e576
  • e576
  • e650
  • e650
  • galzin
  • galzin
  • galzin
  • glucomag
  • gluconate
  • gluconate
  • gluconate
  • gluconic acid
  • gluconic acid
  • gluconic acid
  • gluconic acid
  • gluconic acid
  • gluconic acid
  • gluconic acid, (113)indium-labeled
  • gluconic acid, 1-(14)c-labeled
  • gluconic acid, (14)c-labeled
  • gluconic acid, (159)dysprosium-labeled salt
  • gluconic acid, 6-(14)c-labeled
  • gluconic acid, (99)technecium (5+) salt
  • gluconic acid, aluminum (3:1) salt
  • gluconic acid, ammonium salt
  • gluconic acid, calcium salt
  • gluconic acid, cesium(+3) salt
  • gluconic acid, cobalt (2:1) salt
  • gluconic acid, copper salt
  • gluconic acid, fe(+2) salt, dihydrate
  • gluconic acid, lanthanum(+3) salt
  • gluconic acid, magnesium (2:1) salt
  • gluconic acid, manganese (2:1) salt
  • gluconic acid, monolithium salt
  • gluconic acid, monopotassium salt
  • gluconic acid, monosodium salt
  • gluconic acid, potassium salt
  • gluconic acid sodium salt
  • gluconic acid, sodium salt
  • gluconic acid, strontium (2:1) salt
  • gluconic acid, tin(+2) salt
  • gluconic acid, zinc salt
  • glycogenic acid
  • glyconic acid
  • head & shoulders conditioner
  • hexite
  • lithium gluconate
  • lithium gluconate
  • lithium gluconate
  • magnerot
  • magnesium d-gluconate
  • magnesium d-gluconate
  • magnesium d-gluconate
  • magnesium d-gluconate
  • magnesium gluconate
  • magnesium gluconate
  • magnesium gluconate
  • magnesium gluconate
  • magnesium gluconate
  • magnesium gluconate
  • maltonic acid
  • maltonic acid
  • maltonic acid
  • maltonic acid
  • manganese gluconate
  • monosodium d-gluconate
  • monosodium d-gluconate
  • monosodium d-gluconate
  • monosodium d-gluconate
  • monosodium d-gluconate
  • óxido de cinc
  • óxido de cinc
  • oxyde de zinc
  • oxyde de zinc
  • pate a l'eau
  • pennine
  • pentahydroxycaproic acid
  • polano's
  • pyrithione zinc
  • pyrithione zinc
  • pyrithione zinc
  • pyrithione zinc
  • revlon zp11
  • sebulon
  • sodium gluconate
  • sodium gluconate
  • sodium gluconate
  • sodium gluconate
  • sodium gluconate
  • solvazinc
  • sootheye
  • stiefel brand 1 of zinc pyrithione
  • stiefel brand 2 of zinc pyrithione
  • sudocrem
  • sulfuric acid zinc salt
  • (t-4)-bis(1-hydroxy-2(1h)- pyridinethionato-o,s)zinc
  • vision
  • vision
  • white vitriol
  • white vitriol
  • wilzin
  • wilzin
  • z.e.b.
  • zinc acetate
  • zinc acetate
  • zinc acetate
  • zinc acetate
  • zinc acetate
  • zinc acetate
  • zinc acetate
  • zinc acetate anhydrous
  • zinc acetate anhydrous
  • zinc acetate anhydrous
  • zinc acetate anhydrous
  • zinc acetate dihydrate
  • zinc (as oxide)
  • zinc (as oxide)
  • zinc (as zinc oxide)
  • zinc (as zinc oxide)
  • zincate
  • zinc bromide
  • zinc bromide
  • zinc carbonate
  • zinc carbonate
  • zinc carbonate
  • zinc chloride
  • zinc chloride
  • zinc chloride
  • zinc chloride
  • zinc chloride
  • zinc chloride
  • zinc chloride
  • zinc chloride
  • zinc chloride, (65)zn-labeled
  • zinc citrate
  • zinc citrate
  • zinc citrate
  • zinc diacetate
  • zinc dichloride
  • zincfrin
  • zincfrin
  • zinc gluconate
  • zinc gluconate
  • zinc gluconate
  • zinc gluconate
  • zinc gluconate
  • zinc gluconate trihydrate
  • zinc gluconate trihydrate
  • zinc gluconate trihydrate
  • zinci oxydum
  • zinci oxydum
  • zinc lactate
  • zinc lactate
  • zinc oleate
  • zinc oleate
  • zincomed
  • zincomed
  • zincon (zinc pyrithione)
  • zincosol
  • zinc oxide
  • zinc oxide
  • zinc oxide
  • zinc oxide
  • zinc oxide
  • zinc oxide
  • zinc oxide
  • zinc oxide
  • zinc oxide
  • zinc oxide
  • zinc oxide
  • zinc oxide.
  • zinc oxide.
  • zinc phenolsulphonate
  • zinc phenolsulphonate
  • zincpolyanemine
  • zinc pyridinethione
  • zinc pyrithione
  • zinc pyrithione
  • zinc pyrithione
  • zinc pyrithione
  • zinc sulfate
  • zinc sulfate
  • zinc sulfate
  • zinc sulfate
  • zinc sulfate
  • zinc sulfate
  • zinc sulfate
  • zinc sulfate heptahydrate
  • zinc sulfate heptahydrate
  • zinc sulfate heptahydrate
  • zinc sulfate heptahydrate
  • zinc sulfate heptahydrate
  • zinc sulfate heptahydrate
  • zinc sulfite
  • zinc sulfite
  • zinc sulphate
  • zinc sulphate
  • zinc sulphate
  • zincum oxydatum
  • zincum oxydatum
  • zinc undecylenate
  • zinc undecylenate
  • zinc undecylenate
  • zinc white
  • zinc white
  • zindole
  • zind sulfate
  • zing
  • zinkoxid
  • zinkoxid
  • zn co
  • znp
  • zn sulf co
  • zpt
  • z span

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT06075134N/ANov 30, 2023Cairo University
NCT06042010N/AJan 5, 2023Alexandria University
NCT05465434Phase 3Aug 1, 2022Tanta University
NCT05605886Early Phase 1 (Phase 1)May 20, 2022Cairo University
NCT05157711Phase 3Nov 25, 2021Church & Dwight Company, Inc.
NCT05543603N/AApr 13, 2021Hospital Universitario Infanta Elena, Universidad Autonoma de Madrid, University of Valencia
NCT04371406Phase 3May 2, 2020Assistance Publique - Hôpitaux de Paris
NCT03406793N/AFeb 20, 2018International Center for Diarrheal Disease Research, Johns Hopkins University, University of California, San Francisco, University of Colorado, Denver
NCT03283813Phase 4Feb 5, 2018University of Eastern Piedmont
NCT03158168Phase 3Nov 1, 2017Assiut University
NCT02422368Phase 2/Phase 3 (Phase 3)Sep 1, 2017Isfahan University
NCT03135522Phase 2Jun 15, 2017American Lung Association, Johns Hopkins University, National Heart, Lung, and Blood Institute (NHLBI)
NCT03098810Phase 4Apr 1, 2017Ain Shams University
NCT03078842N/AJan 23, 2017Harvard University, Muhimbili University, World Health Organization
NCT03672513N/ASep 8, 2016University of Granada
NCT02856269N/ASep 1, 2016Case Western Reserve University, National Institutes of Health (NIH), University Hospitals Cleveland Medical Center
NCT02805257Phase 2Jun 1, 2016Asociación para Evitar la Ceguera en México, Bascom Palmer Eye Institute, Sun Yat-Sen University, University of California, San Francisco, University of Colorado, Denver, University of Maryland, University of North Carolina at Chapel Hill
NCT02715466Phase 4Apr 1, 2016B. Braun
NCT02751320N/AFeb 1, 2016GlaxoSmithKline
NCT03112382Phase 4Nov 1, 2015Cairo University
Showing 20 of 109 trials
Page 1 / 6

Organizations

Research & Development (142)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
All India Institute of Medical SciencesAcademic/Hospital5122003
International Center for Diarrheal Disease ResearchAcademic/Hospital5431999
Johns Hopkins UniversityAcademic/Hospital5232000
AlconFor profit3222008
Baylor UniversityAcademic/Hospital3122004
Cairo UniversityAcademic/Hospital3332015
Mayo ClinicAcademic/Hospital3222002
National Institutes of Health (NIH)Government3132001
University of BergenAcademic/Hospital3312003
University of California, San FranciscoAcademic/Hospital3322008
University of Sao PauloAcademic/Hospital3312007
Aga Khan UniversityAcademic/Hospital2212007
Ain Shams UniversityAcademic/Hospital2222014
Allegro Ophthalmics, LLCFor profit2212014
Assiut UniversityAcademic/Hospital2222014
Babylon UniversityAcademic/Hospital2112011
B. BraunFor profit2212010
Bill and Melinda Gates FoundationAcademic/Hospital2012001
Boston UniversityAcademic/Hospital2112007
Duke UniversityAcademic/Hospital2112014
142 organizations
Page 1 / 8

Marketing (22)

OrganizationOrg typeRelationshipDate
AbraxisFor profitNDA2May 5, 1987
ApicoreFor profitMKTGApr 14, 2025
ApotexFor profitMKTGJun 10, 2024
Armour & CompanyFor profitMKTGFeb 22, 1980
Armour & CompanyFor profitNDA2Feb 22, 1980
AspiroFor profitMKTGMay 1, 2025
Daiichi SankyoFor profitNDA2Jul 18, 2019
Eton Pharmaceuticals, Inc.For profitMKTGJan 28, 1997
Exela Pharma Sciences, LLC.For profitMKTGMay 21, 2021
FosunFor profitMKTGMay 3, 2022
FreseniusFor profitMKTGDec 27, 2022
Gland Pharma LtdFor profitMKTGMay 3, 2022
Gland Pharma LtdFor profitSYNMay 3, 2022
HospiraFor profitNDA2Jun 26, 1986
Nivagen Pharmaceuticals Inc.For profitMKTGJul 5, 2024
STIRAFor profitMKTGJun 10, 2025
SankyoFor profitMKTGJul 18, 2019
Somerset PharmaceuticalsFor profitSYNOct 16, 2024
Somerset PharmaceuticalsFor profitMKTGJul 17, 2024
TevaFor profitNDA2Jan 28, 1997
TevaFor profitNDAJan 28, 1997
Zydus Discovery DMCCFor profitMKTGAug 22, 2023