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live oral poliovirus type 1, 2 and 3

Trade name: Trivalent oral polio vaccine - Sabin

Vaccineapproved

Approved

Jun 25, 1963

Clinical trial activity

32 trials · 39 clinical orgs · 0 marketing orgs

Phase 1
4
Phase 2
17
Phase 3
12
Phase 4
12

Earliest trial started Mar 1, 2005 (NCT00263666)

Timeline

1960s

  1. Jun 25, 1963

    Earliest FDA Approval

2000s

  1. Jan 1, 2005

    Earliest Phase 2 Sponsor(trial)

  2. Jan 1, 2006

    Earliest Phase 3 Sponsor(trial)

2010s

  1. Jan 1, 2011

    Earliest Phase 1 Sponsor(trial)

Indications

Approved for

Studied for

Mechanism of action

  • PoliovirusImmunity, active

    Poliovirus immunity, active

Approval history

  • approvedJun 25, 1963

Chemistry & pharmacology

Oral

No

Parenteral

No

Topical

No

Also known as

  • live attenuated poliomyelitis vaccine
  • live oral poliovirus type 1, 2 and 3
  • oral polio vaccine (opv) (also called trivalent oral polio vaccine or sabin vaccine)
  • polio sabin
  • sabin ipv
  • sabin-ipv
  • trivalent opv
  • trivalent oral polio vaccine

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT06266754Phase 4Jan 29, 2024Bandim Health Project, Radboud University
NCT05850364Phase 3May 22, 2023International Center for Diarrheal Disease Research, Sinovac Biotech Co., Ltd
NCT04529538Phase 1Jan 31, 2021Bill and Melinda Gates Foundation, Centers for Disease Control and Prevention (CDC), Dartmouth University, PATH, The EMMES Corporation, University of North Carolina at Chapel Hill, University of Vermont, Viroclinics Biosciences B.V.
NCT04054882Phase 4Aug 31, 2019Beijing Tiantan Bio Co., Ltd, Chengdu Institute of Biological Products Co.,Ltd., China National Biotec Group Co., Ltd, Government of China, Peking University
NCT04053010Phase 4Aug 10, 2019Beijing Tiantan Bio Co., Ltd, China National Biotec Group Co., Ltd, Government of China, Wuhan Institute of Biological Products Co., Ltd
NCT03581734Phase 3Jul 1, 2018Centers for Disease Control and Prevention (CDC), International Center for Diarrheal Disease Research, Stanford University
NCT03597919Phase 4May 28, 2018Centers for Disease Control and Prevention, China, Government of China, World Health Organization
NCT03546634Phase 4May 28, 2018Centers for Disease Control and Prevention, China, Government of China
NCT03092791Phase 1/Phase 2 (Phase 2)Jun 7, 2017Takeda
NCT03147560Phase 4May 2, 2017China National Biotec Group Co., Ltd, Government of China
NCT03460002Phase 4Nov 30, 2016Bandim Health Project, Statens Serum Institut
NCT02582255Phase 4Nov 1, 2015Bill and Melinda Gates Foundation, Fidec Corporation, Vilnius University
NCT02521974Phase 4Oct 1, 2015Bill and Melinda Gates Foundation, Fidec Corporation
NCT02207816Phase 3Sep 18, 2014GlaxoSmithKline
NCT01870206Phase 3Jun 1, 2013Laboratorios de Biologicos y Reactivos de México, S.A. de C.V.
NCT01831050Phase 4May 1, 2013Bill and Melinda Gates Foundation, Centers for Disease Control and Prevention (CDC), Fidec Corporation, University of Colorado, Denver
NCT01813604Phase 3Nov 1, 2012Centers for Disease Control and Prevention (CDC), Government of Bangladesh, International Center for Diarrheal Disease Research, NanoPass Technologies Ltd
NCT01633216Phase 4May 1, 2012International Center for Diarrheal Disease Research
NCT01709071Phase 1/Phase 2 (Phase 2)Feb 1, 2012National Institute for Public Health and the Environment (RIVM), National Institute for Public Health and the Environment, RIVM, Holland, World Health Organization
NCT01345240Phase 3Nov 1, 2011GlaxoSmithKline
Showing 20 of 32 trials
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Organizations

Research & Development (39)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
GlaxoSmithKlineFor profit111122005
Government of ChinaGovernment6122011
Bill and Melinda Gates FoundationAcademic/Hospital4022013
Centers for Disease Control and Prevention (CDC)Government4132012
International Center for Diarrheal Disease ResearchAcademic/Hospital4222012
China National Biotec Group Co., LtdFor profit3212017
Fidec CorporationAcademic/Hospital3312013
PATHAcademic/Hospital3132009
World Health OrganizationGovernment3032011
Bandim Health ProjectGovernment2212016
Beijing Tiantan Bio Co., LtdFor profit2012019
Centers for Disease Control and Prevention, ChinaGovernment2212018
National Institute for Public Health and the Environment (RIVM)Academic/Hospital2222011
AerasAcademic/Hospital1012010
Chengdu Institute of Biological Products Co.,Ltd.Government1012019
Chinese Academy of Medical SciencesAcademic/Hospital1112011
Dartmouth UniversityAcademic/Hospital1012021
Department of State for Health and Social Welfare, The GambiaAcademic/Hospital1012011
Government of BangladeshAcademic/Hospital1012012
Laboratorios de Biologicos y Reactivos de México, S.A. de C.V.Academic/Hospital1112013
39 organizations
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