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pyronaridine

Small moleculeexperimental

Pyronaridine is an antimalarial drug. It was first made in 1970 and has been in clinical use in China since the 1980s. — Wikipedia

Clinical trial activity

36 trials · 43 clinical orgs · 0 marketing orgs

Phase 1
10
Phase 2
23
Phase 3
12
Phase 4
3

Earliest trial started Jul 1, 2005 (NCT01594931)

Timeline

2000s

  1. Jan 1, 2005

    Earliest Phase 2 Sponsor(trial)

  2. Jan 1, 2007

    Earliest Phase 1 Sponsor(trial)

  3. Jan 1, 2007

    Earliest Phase 3 Sponsor(trial)

Indications

Approved for

Studied for

Mechanism of action

Chemistry & pharmacology

Loading structure…

SMILES

COc1ccc2nc3cc(Cl)ccc3c(Nc3cc(CN4CCCC4)c(O)c(CN4CCCC4)c3)c2n1
Mol. weight
518.06 g/mol
Lipinski Ro5
2 violation(s)
Rule of 3
No
Chirality
Achiral Molecule
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • 2-methoxy-7-chloro-10-(3',5'-bis(pyrrolin-1-ylmethyl)-4'-hydroxyphenylamino)benzo(b)-1,5-naphthyridine
  • 4-((7-chloro-2-methoxybenzo(b)-1,5-naphthyridin-10-yl)amino)-2,6-bis(1-pyrrolidinylmethyl)phenol
  • 4-((7-chloro-2-methoxybenzo(b)(1,5)naphthyridin-10-yl)amino)-2,6-bis((pyrrolidin-1-yl)methyl)phenol
  • benzonaphthyridine 7351
  • malaridine
  • malaridine
  • phenol, 4-((7-chloro-2-methoxybenzo(b)-1,5-naphthyridin-10-yl)amino)-2,6-bis(1-pyrrolidinylmethyl)-
  • phenol, 4-((7-chloro-2-methoxybenzo(b)-1,5-naphthyridin-10-yl)amino)-2,6-bis(1-pyrrolidinylmethyl)-, phosphate (1:4)
  • pyonaridine
  • pyronaridine
  • pyronaridine
  • pyronaridine
  • pyronaridine
  • pyronaridine
  • pyronaridine
  • pyronaridine
  • pyronaridine phosphate salt
  • pyronaridine tetraphosphate
  • pyronaridine tetraphosphate
  • pyronaridine tetraphosphate
  • pyronaridine tetraphosphate

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT06962319Phase 3Sep 30, 2025Medicines for Malaria Venture, University of Liverpool
NCT05974267Phase 2Nov 28, 2023Merck KGaA
NCT05929157Phase 1/Phase 2 (Phase 2)Sep 1, 2023Centre de Recherche Médicale de Lambaréné, University of Tuebingen
NCT05689047Phase 2Mar 29, 2023Merck KGaA
NCT05291390Phase 2Nov 21, 2022African Center for Cancer Research and End of Life Care (ACREOL), Rwanda, Armaceutica, Inc., Ifakara Health Institute, Uganda Cancer Institute
NCT05441410Phase 1/Phase 2 (Phase 2)Oct 1, 2022Sanaria Inc., University of Oxford, University of Tuebingen
NCT05633420Phase 2Jul 24, 2022Inha University, Inje University, Shin Poong Pharmaceuticals
NCT05287893Phase 1Apr 4, 2022Medicines for Malaria Venture, Southern Star Research Pty Ltd., Swiss BioQuant A.G., Switzerland, University of Queensland
NCT05160363Phase 1Jan 31, 2022Medicines for Malaria Venture, PharmaKinetics Laboratories Inc., Richmond Pharmacology
NCT05084911Phase 3Oct 18, 2021Shin Poong Pharmaceuticals
NCT04783051Phase 3May 6, 2021European and Developing Countries Clinical Trials Partnership (EDCTP), Novartis, University of Kinshasa
NCT04701606Phase 2/Phase 3 (Phase 3)Mar 29, 2021Shin Poong Pharmaceuticals, University of the Philippines
NCT04695197Phase 3Jan 8, 2021Bill and Melinda Gates Foundation, Centers for Disease Control and Prevention (CDC), Government of Kenya, Groupe de Recherche Action en Santé (GRAS), Burkina Faso, Kenya Medical Research Institute, University of Liverpool, University of London
NCT04532931Phase 2Sep 3, 2020Medicines for Malaria Venture, Shin Poong Pharmaceuticals
NCT04475107Phase 2Jul 9, 2020Shin Poong Pharmaceuticals
NCT04049916Phase 4Aug 31, 2019Malaria Research and Training Center, Bamako, Mali, Radboud University, University of London
NCT05192265Phase 2/Phase 3 (Phase 3)May 20, 2019Shin Poong Pharmaceuticals, University of Ibadan
NCT03726593Phase 4Oct 4, 2018Government of Thailand, National Center for Parasitology, Entomology and Malaria Control
NCT03814616Phase 2Oct 3, 2018Medicines for Malaria Venture, Shin Poong Pharmaceuticals
NCT04264130Phase 2Jul 31, 2018Centre de Recherche Médicale de Lambaréné
Showing 20 of 36 trials
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Organizations

Research & Development (43)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Shin Poong PharmaceuticalsFor profit20742005
Medicines for Malaria VentureAcademic/Hospital181442005
University of OxfordAcademic/Hospital3222012
University of TuebingenAcademic/Hospital3112006
Centre de Recherche Médicale de LambarénéAcademic/Hospital2212018
Mahidol UniversityAcademic/Hospital2022005
Merck KGaAFor profit2212023
University of LiverpoolAcademic/Hospital2212021
University of LondonAcademic/Hospital2122019
African Center for Cancer Research and End of Life Care (ACREOL), RwandaAcademic/Hospital1012022
Armaceutica, Inc.For profit1112022
Bethesda Hospital, Tomohon, North Sulawasi, IndonesiaAcademic/Hospital1012005
Bill and Melinda Gates FoundationAcademic/Hospital1012021
Centers for Disease Control and Prevention (CDC)Government1012021
CovanceFor profit1012012
European and Developing Countries Clinical Trials Partnership (EDCTP)Academic/Hospital1012021
Government of CambodiaGovernment1012015
Government of KenyaGovernment1012021
Government of ThailandGovernment1112018
Groupe de Recherche Action en Santé (GRAS), Burkina FasoAcademic/Hospital1012021
43 organizations
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