← Mechanisms of action
GABA-A receptor; anion channel
PROTEIN COMPLEX GROUPHomo sapiens
Linked proteins
- Gamma-aminobutyric acid receptor subunit alpha-1 (GABRA1) ↗
- Gamma-aminobutyric acid receptor subunit beta-2 (GABRB2) ↗
- Gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2) ↗
- Gamma-aminobutyric acid receptor subunit beta-3 (GABRB3) ↗
- Gamma-aminobutyric acid receptor subunit alpha-4 (GABRA4) ↗
- Gamma-aminobutyric acid receptor subunit gamma-3 (GABRG3) ↗
- Gamma-aminobutyric acid receptor subunit theta (GABRQ) ↗
- Gamma-aminobutyric acid receptor subunit alpha-3 (GABRA3) ↗
- Gamma-aminobutyric acid receptor subunit pi (GABRP) ↗
- Gamma-aminobutyric acid receptor subunit delta (GABRD) ↗
- Gamma-aminobutyric acid receptor subunit gamma-1 (GABRG1) ↗
- Gamma-aminobutyric acid receptor subunit beta-1 (GABRB1) ↗
- Gamma-aminobutyric acid receptor subunit epsilon (GABRE) ↗
- Gamma-aminobutyric acid receptor subunit alpha-2 (GABRA2) ↗
- Gamma-aminobutyric acid receptor subunit alpha-5 (GABRA5) ↗
- Gamma-aminobutyric acid receptor subunit alpha-6 (GABRA6) ↗
Drugs acting on this target (59)
| Active Pharmaceutical Ingredient | Mechanism Type ▲ | Approval Status | API Type | Mechanism of Action |
|---|---|---|---|---|
| abp-700 | Agonist | experimental | Small molecule | GABA-A receptor; anion channel agonist |
| cvl-865 | Agonist | experimental | Small molecule | GABA-A receptor; anion channel agonist |
| pf-06372865 | Agonist | experimental | Small molecule | GABA-A receptor; anion channel agonist |
| propofol (diprivan) | Agonist | approved | Small molecule | GABA-A receptor; anion channel agonist |
| flumazenil (mazicon ) | Allosteric antagonist | approved | Small molecule | GABA-A receptor; anion channel allosteric antagonist |
| etifoxine (Stresam) | Antagonist | experimental | Small molecule | GABA-A receptor; anion channel antagonist |
| radequinil | Inverse agonist | experimental | Small molecule | GABA-A receptor; anion channel inverse agonist |
| adipiplon | Partial agonist | experimental | Small molecule | GABA-A receptor; anion channel partial agonist |
| padsevonil | Partial agonist | experimental | Small molecule | GABA-A receptor; anion channel partial agonist |
| alprazolam | Positive allosteric modulator | approved | Small molecule | GABA-A receptor; anion channel positive allosteric modulator |
| brexanolone (Zulresso) | Positive allosteric modulator | approved | Small molecule | GABA-A receptor; anion channel positive allosteric modulator |
| butabarbital (neonal) | Positive allosteric modulator | approved | Small molecule | GABA-A receptor; anion channel positive allosteric modulator |
| butalbital (fiornal) | Positive allosteric modulator | approved | Small molecule | GABA-A receptor; anion channel positive allosteric modulator |
| cenobamate (Xcopri) | Positive allosteric modulator | approved | Small molecule | GABA-A receptor; anion channel positive allosteric modulator |
| chlordiazepoxide (librium) | Positive allosteric modulator | approved | Small molecule | GABA-A receptor; anion channel positive allosteric modulator |
| clobazam (onfi) | Positive allosteric modulator | approved | Small molecule | GABA-A receptor; anion channel positive allosteric modulator |
| clonazepam (klonopin) | Positive allosteric modulator | approved | Small molecule | GABA-A receptor; anion channel positive allosteric modulator |
| clorazepate (tranxene) | Positive allosteric modulator | approved | Small molecule | GABA-A receptor; anion channel positive allosteric modulator |
| clotiazepam | Positive allosteric modulator | experimental | Small molecule | GABA-A receptor; anion channel positive allosteric modulator |
| desflurane (suprane) | Positive allosteric modulator | approved | Small molecule | GABA-A receptor; anion channel positive allosteric modulator |
| diazepam (valium) | Positive allosteric modulator | approved | Small molecule | GABA-A receptor; anion channel positive allosteric modulator |
| emineurina | Positive allosteric modulator | experimental | Small molecule | GABA-A receptor; anion channel positive allosteric modulator |
| estazolam (prosom) | Positive allosteric modulator | approved | Small molecule | GABA-A receptor; anion channel positive allosteric modulator |
| eszopiclone (lunesta) | Positive allosteric modulator | approved | Small molecule | GABA-A receptor; anion channel positive allosteric modulator |
| flunitrazepam | Positive allosteric modulator | experimental | Small molecule | GABA-A receptor; anion channel positive allosteric modulator |
| flurazepam (dalmane) | Positive allosteric modulator | approved | Small molecule | GABA-A receptor; anion channel positive allosteric modulator |
| ganaxolone (Ztalmy) | Positive allosteric modulator | approved | Small molecule | GABA-A receptor; anion channel positive allosteric modulator |
| halazepam (paxipam) | Positive allosteric modulator | approved | Small molecule | GABA-A receptor; anion channel positive allosteric modulator |
| halothane (fluothane) | Positive allosteric modulator | approved | Small molecule | GABA-A receptor; anion channel positive allosteric modulator |
| isoflurane (forane) | Positive allosteric modulator | approved | Small molecule | GABA-A receptor; anion channel positive allosteric modulator |
| methaqualone | Positive allosteric modulator | approved | Small molecule | GABA-A receptor; anion channel positive allosteric modulator |
| metharbital (gemonil) | Positive allosteric modulator | approved | Small molecule | GABA-A receptor; anion channel positive allosteric modulator |
| methohexital sodium (brevital sodium) | Positive allosteric modulator | approved | Small molecule | GABA-A receptor; anion channel positive allosteric modulator |
| methyprylon (noludar) | Positive allosteric modulator | approved | Small molecule | GABA-A receptor; anion channel positive allosteric modulator |
| midazolam (versed) | Positive allosteric modulator | approved | Small molecule | GABA-A receptor; anion channel positive allosteric modulator |
| oxazepam (serax) | Positive allosteric modulator | approved | Small molecule | GABA-A receptor; anion channel positive allosteric modulator |
| pagoclone | Positive allosteric modulator | experimental | Small molecule | GABA-A receptor; anion channel positive allosteric modulator |
| pentobarbital (nembutal) | Positive allosteric modulator | approved | Small molecule | GABA-A receptor; anion channel positive allosteric modulator |
| prazepam (centrax) | Positive allosteric modulator | approved | Small molecule | GABA-A receptor; anion channel positive allosteric modulator |
| primidone (mysoline) | Positive allosteric modulator | approved | Small molecule | GABA-A receptor; anion channel positive allosteric modulator |
| propofol (diprivan) | Positive allosteric modulator | approved | Small molecule | GABA-A receptor; anion channel positive allosteric modulator |
| quazepam (doral) | Positive allosteric modulator | approved | Small molecule | GABA-A receptor; anion channel positive allosteric modulator |
| remimazolam (Byfavo) | Positive allosteric modulator | approved | Small molecule | GABA-A receptor; anion channel positive allosteric modulator |
| sevoflurane (ultane) | Positive allosteric modulator | approved | Small molecule | GABA-A receptor; anion channel positive allosteric modulator |
| talbutal (lotusate) | Positive allosteric modulator | approved | Small molecule | GABA-A receptor; anion channel positive allosteric modulator |
| temazepam (restoril) | Positive allosteric modulator | approved | Small molecule | GABA-A receptor; anion channel positive allosteric modulator |
| tetrazepam | Positive allosteric modulator | experimental | Small molecule | GABA-A receptor; anion channel positive allosteric modulator |
| thiamylal (surital) | Positive allosteric modulator | approved | Small molecule | GABA-A receptor; anion channel positive allosteric modulator |
| thiopental (pentothal) | Positive allosteric modulator | approved | Small molecule | GABA-A receptor; anion channel positive allosteric modulator |
| triazolam (halcion) | Positive allosteric modulator | approved | Small molecule | GABA-A receptor; anion channel positive allosteric modulator |
| zuranolone (ZURZUVAE) | Positive allosteric modulator | approved | Small molecule | GABA-A receptor; anion channel positive allosteric modulator |
| acamprosate (campral) | Positive modulator | approved | Small molecule | GABA-A receptor; anion channel positive modulator |
| enflurane (ethrane) | Positive modulator | approved | Small molecule | GABA-A receptor; anion channel positive modulator |
| ethchlorvynol (placidyl) | Positive modulator | approved | Small molecule | GABA-A receptor; anion channel positive modulator |
| etomidate (amidate) | Positive modulator | approved | Small molecule | GABA-A receptor; anion channel positive modulator |
| glutethimide (doriden) | Positive modulator | approved | Small molecule | GABA-A receptor; anion channel positive modulator |
| methoxyflurane (penthrane) | Positive modulator | approved | Small molecule | GABA-A receptor; anion channel positive modulator |
| topiramate (topamax) | Positive modulator | approved | Small molecule | GABA-A receptor; anion channel positive modulator |
| triclofos (triclos) | Positive modulator | approved | Small molecule | GABA-A receptor; anion channel positive modulator |