d-aspartate
Small moleculeexperimental
Aspartic acid, is an α-amino acid that is used in the biosynthesis of proteins. The L-isomer of aspartic acid is one of the 22 proteinogenic amino acids, i.e., the building blocks of proteins. D-aspartic acid is one of two D-amino acids commonly found in mammals. Apart from a few rare exceptions, D-aspartic acid is not used for protein synthesis but is incorporated into some peptides and plays a role as a neurotransmitter/neuromodulator. — Wikipedia
Clinical trial activity
2 trials · 2 clinical orgs · 0 marketing orgs
Phase 1
1
Phase 2
1
Phase 3
0
Phase 4
0
Earliest trial started Nov 22, 2017 (NCT03228524)
Timeline
Indications
Mechanism of action
- Metabotropic glutamate receptor 5ACTIVATOR
GRM5 activator
Chemistry & pharmacology
Loading structure…
SMILES
N[C@H](CC(=O)O)C(=O)O- Mol. weight
- 133.1 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaAspartic acid ↗
- ChEMBLCHEMBL29757 ↗
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT03387046 | Phase 2 | Mar 26, 2018 | Merck KGaA |
| NCT03228524 | Early Phase 1 (Phase 1) | Nov 22, 2017 | Neuromed IRCCS |
Showing 2 of 2 trials
Page 1 / 1
Organizations
Research & Development (2)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Merck KGaA | For profit | 1 | 1 | 1 | 2018 |
| Neuromed IRCCS | Academic/Hospital | 1 | 1 | 1 | 2017 |
2 organizations
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