Anti-thymocyte Globulin (Rabbit)
Trade name: Thymoglobulin
Animal productapproved
Approved
Dec 30, 1998
Thymoglobulin is an anti-human thymocyte immunoglobulin preparation made of purified polyclonal antibodies derived from rabbits. While these antibodies have a variety of specificities, their main mechanism of immunosuppression is through depletion of T cells. Thymoglobulin is currently approved for clinical use in Europe and the United States for renal allograft rejection, prevention of graft-vs.-host disease, and conditions involving bone marrow failure, including aplastic anemia and has additional off-label uses. — Wikipedia
Clinical trial activity
544 trials · 304 clinical orgs · 1 marketing orgs
Phase 1
109
Phase 2
356
Phase 3
62
Phase 4
68
Earliest trial started May 1, 1993 (NCT00002534)
Timeline
Indications
Approved for
Studied for
- Acne Vulgaris · Phase 3
- Adrenoleukodystrophy · Phase 2/Phase 3
- Allergy and Immunology · Phase 2/Phase 3
- Allogeneic Cells · Phase 2
- Allografts · Phase 2
- Anaplasia · Phase 2
- Anemia · Phase 4
- Anemia, Aplastic · Phase 4
- Anemia, Diamond-Blackfan · Phase 2/Phase 3
- Anemia, Hemolytic, Autoimmune · Phase 2/Phase 3
- Anemia, Sickle Cell · Phase 2/Phase 3
- Antilymphocyte Serum · Phase 2
- Autoimmune Diseases · Phase 2
- Autoimmune Diseases of the Nervous System · Phase 2
- beta-Thalassemia · Phase 4
- Bone Marrow Cells · Phase 2
- Bone Marrow Failure Disorders · Phase 3
- Bone Marrow Transplantation · Phase 3
- Brain Injuries · Phase 2
- Brain Neoplasms · Phase 1
- Breast Neoplasms · Phase 2
- Bronchiectasis · Phase 3
- Burkitt Lymphoma · Phase 2
- Carcinoma, Hepatocellular · Phase 2
- Cerebellar Diseases · Phase 2
- Chediak-Higashi Syndrome · Phase 2
- Choroid Plexus Neoplasms · Phase 1
- Chronic Disease · Phase 2
- Chronic Kidney Disease-Mineral and Bone Disorder · Phase 4
- Crohn Disease · Phase 2
- Cyclosporine · Phase 4
- Cystic Fibrosis · Phase 3
- Cystinosis · Phase 1/Phase 2
- Cytomegalovirus · Phase 4
- Cytomegalovirus Infections · Phase 4
- Desmoplastic Small Round Cell Tumor · Phase 2
- Diabetes Mellitus · Phase 4
- Diabetes Mellitus, Type 1 · Phase 3
- Diabetic Nephropathies · Phase 4
- DiGeorge Syndrome · Phase 1/Phase 2
- Drug-Related Side Effects and Adverse Reactions · Phase 2
- Drugs, Investigational · Phase 4
- Drug Therapy · Phase 4
- Dyskeratosis Congenita · Phase 2/Phase 3
- Encephalitis · Phase 2
- Ependymoma · Phase 1
- Epidermolysis Bullosa · Phase 2
- Fanconi Anemia · Phase 2
- Fucosidosis · Phase 2/Phase 3
- Gangliosidosis, GM1 · Phase 2/Phase 3
- Gaucher Disease · Phase 2/Phase 3
- Genetic Diseases, Inborn · Phase 2
- Glioma · Phase 1
- Glomerulonephritis · Phase 4
- Glomerulosclerosis, Focal Segmental · Phase 1/Phase 2
- Graft Rejection · Phase 4
- Graft vs Host Disease · Phase 4
- Hair · Phase 2
- Heart Transplantation · Phase 2
- Hematologic Diseases · Phase 2
- Hematologic Neoplasms · Phase 3
- Hematopoietic Stem Cell Transplantation · Phase 4
- Hemoglobinopathies · Phase 2
- Hemoglobinuria, Paroxysmal · Phase 2
- Histiocytosis, Langerhans-Cell · Phase 2
- Hodgkin Disease · Phase 3
- Hypoglycemia · Phase 1/Phase 2
- Idiopathic Pulmonary Fibrosis · Phase 3
- Immune System Diseases · Phase 2
- Immunologic Deficiency Syndromes · Phase 2
- Immunosuppression Therapy · Phase 4
- Infections · Phase 2
- Intestinal Neoplasms · Phase 2
- Kidney Diseases · Phase 4
- Kidney Failure, Chronic · Phase 4
- Kidney Neoplasms · Phase 2
- Kidney Transplantation · Phase 4
- Kidney Tubular Necrosis, Acute · Phase 1/Phase 2
- Lambert-Eaton Myasthenic Syndrome · Phase 2
- Latent Infection · Phase 2
- Leukemia · Phase 4
- Leukemia, Biphenotypic, Acute · Phase 2
- Leukemia, Large Granular Lymphocytic · Phase 2
- Leukemia, Lymphocytic, Chronic, B-Cell · Phase 2
- Leukemia, Lymphoid · Phase 3
- Leukemia-Lymphoma, Adult T-Cell · Phase 2
- Leukemia, Monocytic, Acute · Phase 2
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive · Phase 2/Phase 3
- Leukemia, Myeloid · Phase 3
- Leukemia, Myeloid, Acute · Phase 4
- Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative · Phase 3
- Leukemia, Myeloid, Chronic-Phase · Phase 2
- Leukemia, Myelomonocytic, Acute · Phase 2
- Leukemia, Myelomonocytic, Chronic · Phase 3
- Leukemia, Myelomonocytic, Juvenile · Phase 2
- Leukemia, Plasma Cell · Phase 2
- Leukemia, Prolymphocytic · Phase 2
- Leukemia, Prolymphocytic, T-Cell · Phase 1/Phase 2
- Leukodystrophy, Globoid Cell · Phase 2/Phase 3
- Leukodystrophy, Metachromatic · Phase 2/Phase 3
- Livedoid Vasculopathy · Phase 4
- Liver Diseases · Phase 4
- Liver Failure · Phase 2
- Liver Transplantation · Phase 4
- Living Donors · Phase 4
- Lung Diseases · Phase 3
- Lung Transplantation · Phase 3
- Lupus Erythematosus, Systemic · Phase 2
- Lymphocytes · Phase 2
- Lymphohistiocytosis, Hemophagocytic · Phase 2
- Lymphoid Tissue · Phase 2/Phase 3
- Lymphoma · Phase 4
- Lymphoma, B-Cell · Phase 2
- Lymphoma, B-Cell, Marginal Zone · Phase 2
- Lymphoma, Follicular · Phase 2
- Lymphoma, Large B-Cell, Diffuse · Phase 2
- Lymphoma, Large-Cell, Anaplastic · Phase 2
- Lymphoma, Large-Cell, Immunoblastic · Phase 2
- Lymphoma, Mantle-Cell · Phase 2
- Lymphoma, Non-Hodgkin · Phase 3
- Lymphoma, Primary Cutaneous Anaplastic Large Cell · Phase 2
- Lymphoma, T-Cell · Phase 2
- Lymphoma, T-Cell, Cutaneous · Phase 2
- Lymphoma, T-Cell, Peripheral · Phase 2
- Lymphomatoid Granulomatosis · Phase 2
- Lymphoproliferative Disorders · Phase 2
- Mannosidase Deficiency Diseases · Phase 2
- Medulloblastoma · Phase 1
- Melanoma · Phase 1/Phase 2
- Metabolic Diseases · Phase 2
- Mucopolysaccharidosis I · Phase 2
- Mucopolysaccharidosis VI · Phase 2
- Multiple Myeloma · Phase 4
- Multiple Sclerosis · Phase 2
- Multiple Sclerosis, Relapsing-Remitting · Phase 3
- Muscular Diseases · Phase 1
- Myasthenia Gravis · Phase 2
- Mycoses · Phase 2
- Myelodysplastic-Myeloproliferative Diseases · Phase 2/Phase 3
- Myelodysplastic Syndromes · Phase 4
- Myeloid Cells · Phase 1
- Myeloproliferative Disorders · Phase 3
- Neoplasm Metastasis · Phase 1/Phase 2
- Neoplasm, Residual · Phase 2
- Neoplasms · Phase 4
- Neoplasms, Germ Cell and Embryonal · Phase 1
- Neoplasms, Plasma Cell · Phase 2
- Nephritis · Phase 1/Phase 2
- Nerve Sheath Neoplasms · Phase 2
- Neural Tube Defects · Phase 2
- Neuroblastoma · Phase 2
- Neuroectodermal Tumors · Phase 1
- Neuroectodermal Tumors, Primitive · Phase 1
- Neuromyelitis Optica · Phase 2/Phase 3
- Neuronal Ceroid-Lipofuscinoses · Phase 2/Phase 3
- Neutropenia · Phase 2/Phase 3
- Niemann-Pick Diseases · Phase 2/Phase 3
- Opsoclonus-Myoclonus Syndrome · Phase 2
- Organ Preservation Solutions · Phase 4
- Organ Transplantation · Phase 4
- Ovarian Neoplasms · Phase 2
- Ovulation Induction · Phase 4
- Pancytopenia · Phase 2
- Pediatrics · Phase 1
- Peripheral Blood Stem Cell Transplantation · Phase 3
- Plasmacytoma · Phase 2
- Polyradiculoneuropathy, Chronic Inflammatory Demyelinating · Phase 2
- Precancerous Conditions · Phase 2
- Precursor B-Cell Lymphoblastic Leukemia-Lymphoma · Phase 3
- Precursor Cell Lymphoblastic Leukemia-Lymphoma · Phase 4
- Precursor T-Cell Lymphoblastic Leukemia-Lymphoma · Phase 1/Phase 2
- Primary Immunodeficiency Diseases · Phase 2
- Primary Myelofibrosis · Phase 2/Phase 3
- Pulmonary Disease, Chronic Obstructive · Phase 3
- Rabies · Phase 1/Phase 2
- Recurrence · Phase 3
- Renal Insufficiency · Phase 4
- Reperfusion Injury · Phase 4
- Rhabdoid Tumor · Phase 1
- Rhabdomyosarcoma · Phase 2
- Sandhoff Disease · Phase 2/Phase 3
- Sarcoma · Phase 2
- Sarcoma, Ewing · Phase 2
- Sarcoma, Myeloid · Phase 2
- Scleroderma, Systemic · Phase 3
- Severe Combined Immunodeficiency · Phase 1/Phase 2
- Sezary Syndrome · Phase 2
- Shwachman-Diamond Syndrome · Phase 2/Phase 3
- Stem Cells · Phase 4
- Stem Cell Transplantation · Phase 3
- Stiff-Person Syndrome · Phase 2
- Tay-Sachs Disease · Phase 2/Phase 3
- Thalassemia · Phase 2/Phase 3
- Thrombocytopenia · Phase 2
- Thymoma · Phase 2
- Thyroid Neoplasms · Phase 1/Phase 2
- Transplantation · Phase 4
- Transplantation, Autologous · Phase 2
- Transplantation, Homologous · Phase 2
- Vascular Grafting · Phase 3
- Vasculitis · Phase 1
- Vasculitis, Central Nervous System · Phase 2
- Virus Diseases · Phase 2/Phase 3
- Waldenstrom Macroglobulinemia · Phase 2
- Wiskott-Aldrich Syndrome · Phase 1/Phase 2
- Wolman Disease · Phase 2/Phase 3
Mechanism of action
- ThymocytesImmunity, passive
Thymocytes immunity, passive
Approval history
- approvedDec 30, 1998
Chemistry & pharmacology
Loading structure…
SMILES
CS(=O)(=O)OCCCCOS(C)(=O)=O- Mol. weight
- 246.31 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
- Delivery
- Oral, Parenteral
- Availability
- Prescription Only
Oral
Yes
Parenteral
Yes
Topical
No
Black box warning
Sources
- WikipediaThymoglobulin ↗
- NCATSD7RD81HE4W ↗
- ChEMBLCHEMBL820 ↗
- WikipediaATG ↗
Also known as
- anti-human thymocyte globulin (rabbit)
- anti-human thymocyte immunoglobulin, rabbit
- anti-thymocyte globin
- anti-thymocyte globulin
- antithymocyte globulin
- anti-thymocyte globulin rabbit
- anti-thymocyte globulin (rabbit)
- anti-thymocyte globulin (rabbit)
- anti-thymocyte globulin (rabbit)
- antithymocyte immunoglobulin
- antithymocyte immunoglobulin
- antithymocyte immunoglobulin (rabbit)
- anti-t-lymphocyte immune globulin, rabbit
- atg
- atg
- busulfex
- busulfex
- lapine t-lymphocyte immune globuin
- rabbit anti-human thymocyte globulin
- rabbit anti-human thymocyte globulin
- rabbit anti-human thymocyte globulin (ratg)
- rabbit anti-human thymocyte immunoglobulin
- rabbit anti-thymocyte globulin
- rabbit antithymocyte globulin
- rabbit antithymocyte globulin
- rabbit anti-thymocyte immunoglobulin
- rabbit anti-thymocyte immunoglobulin
- rabbit atg
- rabbit atg
- rabbit thymoglobulin
- ratg
- thymoglobulin
- thymoglobulin
- thymoglobulin
- thymoglobulin
- thymoglobuline
- thymogolubulin
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07061574 | Phase 1/Phase 2 (Phase 2) | Dec 15, 2026 | City of Hope National Medical Center, Jaeb Center for Health Research |
| NCT07257419 | Phase 1 | Dec 31, 2025 | St. Jude Children's Hospital |
| NCT07052370 | Phase 1 | Dec 31, 2025 | St. Jude Children's Hospital |
| NCT07216391 | Phase 2 | Dec 1, 2025 | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) |
| NCT07187531 | Phase 2 | Oct 31, 2025 | SAB Biotherapeutics |
| NCT06986382 | Phase 1/Phase 2 (Phase 2) | Jul 31, 2025 | Stanford University |
| NCT06315309 | Phase 2 | Jun 29, 2025 | University of Alabama, Birmingham |
| NCT06984536 | Phase 2 | May 21, 2025 | Peking University |
| NCT06455319 | Phase 2 | Apr 30, 2025 | University of Colorado, Denver, University of Florida, University of Miami |
| NCT06265584 | Phase 2 | Jan 31, 2025 | University of Alabama, Birmingham |
| NCT06744400 | Phase 1 | Jan 15, 2025 | University of Franche-Comté |
| NCT06872333 | Phase 2 | Nov 19, 2024 | University of Minnesota |
| NCT06252870 | Phase 2 | Jul 18, 2024 | University of Angers, University of Nantes, University of Western Brittany |
| NCT06299462 | Phase 1/Phase 2 (Phase 2) | Jun 20, 2024 | Government of Brazil |
| NCT06412497 | Phase 2 | Jun 5, 2024 | University of Minnesota |
| NCT05757310 | Phase 1 | Apr 1, 2024 | City of Hope National Medical Center, National Cancer Institute (NCI) |
| NCT06279494 | Phase 1/Phase 2 (Phase 2) | Mar 31, 2024 | Peking University |
| NCT06158828 | Phase 1/Phase 2 (Phase 2) | Mar 31, 2024 | Rising Tide Foundation, The Leukemia and Lymphoma Society, Washington University in St. Louis |
| NCT06066255 | Phase 2 | Mar 31, 2024 | Institut Paoli-Calmettes, Sanofi |
| NCT06334367 | Phase 2 | Mar 26, 2024 | Shandong Provincial Hospital |
Showing 20 of 544 trials
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Organizations
Research & Development (304)
304 organizations
Page 1 / 16