calcium chloride

Trade name: calcium chloride

Small moleculeapproved

Approved

Dec 7, 1953

Calcium chloride is an inorganic compound, a salt with the chemical formula CaCl2. It is a white crystalline solid at room temperature, and it is highly soluble in water. It can be created by neutralising hydrochloric acid with calcium hydroxide. — Wikipedia

Clinical trial activity

26 trials · 27 clinical orgs · 46 marketing orgs

Phase 1

Phase 2

Phase 3

Phase 4

Earliest trial started Jun 1, 2006 (NCT00378872)

Timeline

1940s

Jun 1, 1941
Evidence of US Marketing

1950s

Dec 7, 1953
Earliest FDA Approval
Dec 7, 1953
Strides Pharma Science — Marketing Organization
Dec 7, 1953
DAVA Pharmaceuticals — Marketing Organization

1970s

Mar 22, 1971
Baxter — First NDA Organization
Mar 22, 1971
Baxalta — Marketing Organization
Mar 22, 1971
Baxter — NDA Secondary Org
Mar 22, 1971
Baxter — NDA Organization
Aug 13, 1975
ICU Medical Inc — Marketing Organization
Aug 13, 1975
ICU Medical Inc — NDA Secondary Org
Feb 8, 1978
B. Braun — Marketing Organization
Feb 8, 1978
B. Braun — NDA Secondary Org
Sep 5, 1979
Bristol-Myers — Marketing Organization

1980s

Jan 15, 1980
Hospira — NDA Secondary Org
Oct 28, 1981
Nestle — NDA Secondary Org
Feb 14, 1985
Bristol-Myers Squibb — Marketing Organization
May 9, 1986
Norbrook — Marketing Organization
Jun 13, 1986
Abraxis — Marketing Organization
Sep 16, 1986
West-Ward Pharmaceutical — Marketing Organization
Nov 7, 1988
Hospira — Marketing Organization

1990s

Oct 15, 1990
Barr Laboratories — Marketing Organization
Aug 23, 1991
Pharmacia & Upjohn — Marketing Organization
Nov 27, 1991
Akorn, Inc. — Marketing Organization
Nov 27, 1991
Akorn, Inc. — NDA Secondary Org
Nov 27, 1991
Epic Pharma Llc — NDA Secondary Org
May 15, 1992
Mylan — Marketing Organization
Jun 13, 1994
Fresenius — Marketing Organization
Aug 1, 1994
Hikma — Marketing Organization
Sep 27, 1996
Lukare Medical — Marketing Organization
Sep 27, 1996
Lukare Medical — NDA Secondary Org
Jun 17, 1999
Duramed Research — Marketing Organization

2000s

Apr 21, 2000
Baxter — Marketing Organization
Oct 25, 2006
Baxalta — NDA Secondary Org
Apr 30, 2007
Accord Research — Marketing Organization
Jul 24, 2008
Alcon — Marketing Organization
Jan 1, 2009
Earliest Phase 2 Sponsor(trial)
Mar 31, 2009
Sandoz — Marketing Organization

2010s

Jan 8, 2010
Pharmachemie Bv — Marketing Organization
Mar 29, 2012
EXTROVIS — Marketing Organization
Jan 1, 2013
Earliest Phase 1 Sponsor(trial)
Jan 1, 2014
Earliest Phase 3 Sponsor(trial)
Aug 25, 2014
Fresenius — NDA Secondary Org
May 21, 2015
Sun Pharmaceuticals — Marketing Organization
Jan 13, 2017
Zydus Discovery DMCC — Marketing Organization
Apr 25, 2017
Silvergate Pharmaceuticals — Marketing Organization
Apr 25, 2017
Azurity — Marketing Organization
Jul 27, 2017
Lutipold — Marketing Organization
Jul 27, 2017
Sankyo — Marketing Organization
Jul 27, 2017
Daiichi Sankyo — Marketing Organization
Dec 22, 2017
Amneal Pharmaceuticals — Marketing Organization
May 9, 2018
International Medication — Marketing Organization
Aug 9, 2018
Sagent Pharmaceuticals, Inc. — Marketing Organization
May 1, 2019
Medefil — Marketing Organization

2020s

Jan 30, 2020
Eugia Pharma — Marketing Organization
Apr 23, 2021
Lotus Pharmaceutical — Marketing Organization
Aug 7, 2023
Daito Pharmaceuticals — Marketing Organization
May 16, 2024
Elite Laboratories, Inc — Marketing Organization
Jun 3, 2024
Alembic — Marketing Organization
Dec 17, 2024
Somerset Pharmaceuticals — Marketing Organization

Indications

Approved for

Studied for

Mechanism of action

CalciumSupplementation
Calcium supplementation

Combination products

acetated ringer's
with potassium chloride, sodium acetate, sodium chloride
aminosyn ii w/ electrolytes in dextrose w/ calcium
with potassium chloride, amino acids, sodium chloride, potassium phosphate, glucose monohydrate, magnesium
bss plus
with potassium chloride, sodium bicarbonate, sodium phosphate, sodium chloride, glucose monohydrate, glutathione, magnesium
Also known as methotrexate sodium
clinimix e 4.25/25 sulfite free w/ elect in dextrose w/ calcium
with sodium acetate, amino acids, sodium chloride, potassium phosphate, glucose monohydrate, magnesium
Also known as clinimix e 2.75/10 sulfite free w/ elect in dextrose w/ calcium, clinimix e 2.75/25 sulfite free w/ elect in dextrose w/ calcium, clinimix e 2.75/5 sulfite free w/ elect in dextrose w/ calcium, clinimix e 4.25/10 sulfite free w/ elect in dextrose w/ calcium, clinimix e 4.25/20 sulfite free w/ elect in dextrose w/ calcium, clinimix e 4.25/5 sulfite free w/ elect in dextrose w/ calcium, clinimix e 5/10 sulfite free w/ elect in dextrose w/ calcium, clinimix e 5/15 sulfite free w/ elect in dextrose w/ calcium, clinimix e 5/20 sulfite free w/ elect in dextrose w/ calcium, clinimix e 5/25 sulfite free w/ elect in dextrose w/ calcium, clinimix e 5/35 sulfite free w/ elect in dextrose w/ calcium
dextrose in acetated ringer's
with potassium chloride, sodium acetate, sodium chloride, glucose monohydrate
dextrose in ringer's
with potassium chloride, sodium chloride, glucose monohydrate
Also known as dextrose and ringer's
dialyte w/ dextrose
with sodium acetate, sodium chloride, glucose monohydrate, magnesium
Also known as dialyte concentrate w/ dextrose
dianeal low calcium w/dextrose
with lactic acid, sodium chloride, glucose monohydrate, magnesium
Also known as delflex-lm w/ dextrose, delflex w/ dextrose, delflex w/ dextrose low magnesium, delflex w/ dextrose low magnesium low calcium, dianeal 137 w/ dextrose, dianeal low calcium w/ dextrose, dianeal pd-1 w/ dextrose, dianeal pd-2 w/ dextrose, inpersol-lc/lm w/ dextrose
elliotts b solution
with potassium chloride, magnesium sulfate, sodium bicarbonate, sodium phosphate, sodium chloride, glucose monohydrate
inpersol-zm w/ dextrose
with lactic acid, sodium chloride, glucose monohydrate
isolyte e
with sodium citrate, potassium chloride, sodium acetate, sodium chloride, magnesium
Also known as balanced salt, bss
isolyte e w/ dextrose
with sodium citrate, potassium chloride, sodium acetate, sodium chloride, glucose monohydrate, magnesium
Also known as isolyte e in dextrose
isolyte r w/ dextrose
with potassium chloride, sodium acetate, sodium chloride, glucose monohydrate, magnesium
Also known as isolyte r in dextrose
kabiven
with soybean oil, potassium chloride, magnesium sulfate, sodium acetate, amino acids, sodium glycerophosphate pentahydrate, glucose monohydrate
Also known as perikabiven
lactated ringer's
with potassium chloride, lactic acid, sodium chloride
lactated ringer's and dextrose
with potassium chloride, lactic acid, sodium chloride, glucose monohydrate
Also known as dextrose and lactated ringer's, dextrose in half-strength lactated ringer's, dextrose in lactated ringer's, dextrose in modified lactated ringer's, potassium chloride in dextrose and lactated ringer's
navstel
with potassium chloride, sodium bicarbonate, sodium phosphate, sodium chloride, oxiglutatione, glucose monohydrate, magnesium
phoxillum bk
with potassium chloride, sodium bicarbonate, sodium phosphate, sodium chloride, magnesium
Also known as phoxillum b22k
plasma-lyte m and dextrose
with potassium chloride, sodium acetate, lactic acid, sodium chloride, glucose monohydrate, magnesium
plasma-lyte r
with potassium chloride, sodium acetate, lactic acid, sodium chloride, magnesium
plegisol
with potassium chloride, sodium chloride, magnesium
Also known as cardioplegic
prismasol bk
with potassium chloride, lactic acid, sodium bicarbonate, sodium chloride, glucose monohydrate, magnesium
Also known as prismasol b22gk, prismasol bgk
ringer's
with potassium chloride, sodium chloride
tpn electrolytes
with potassium chloride, sodium acetate, sodium chloride, magnesium

Approval history

approvedPriority reviewDec 7, 1953
approvedJun 1, 1941

Chemistry & pharmacology

Loading structure…

SMILES

[Ca+2].[Cl-].[Cl-]

Mol. weight: 110.98 g/mol
Chirality: Achiral Molecule
Inorganic: Yes
Polymer: No
Delivery: Parenteral
Availability: Prescription Only

Oral

Parenteral

Yes

Topical

Sources

WikipediaCalcium chloride ↗
ChEMBLCHEMBL1200668 ↗

Also known as

calcium(2+) chloride
calcium chloride
calcium chloride
calcium chloride
calcium chloride
calcium chloride
calcium chloride
calcium chloride
calcium chloride
calcium chloride
calcium chloride anhydrous
calcium chloride anhydrous
calcium chloride, anhydrous
calcium chloride, anhydrous
calcium chloride dihydrate
calcium chloride dihydrate
cal plus
cal plus
e509
e509
glandosane
hypozalix
ringerfundin

Clinical trials

NCT ID	Phase	Start date	Sponsor(s)
NCT07187544	N/A	Sep 30, 2025	Icahn School of Medicine at Mount Sinai, Mount Sinai Hospital, Canada
NCT06378021	Phase 3	Mar 14, 2024	Helwan University, Istanbul University
NCT05973747	Early Phase 1 (Phase 1)	Sep 1, 2023	Stanford University
NCT05027048	Phase 3	Jan 31, 2023	Stanford University
NCT04660721	Phase 1/Phase 2 (Phase 2)	Dec 31, 2020	Sealantium Medical Ltd.
NCT04153435	Phase 2	Jan 31, 2020	Aarhus University, Central Denmark Region
NCT05046262	Phase 3	Jan 8, 2020	Mirai Medical, Ireland, University of Copenhagen
NCT04713319	Early Phase 1 (Phase 1)	Oct 4, 2019	Replicon Health Oy, University of Jyvaskyla
NCT03867383	Phase 1/Phase 2 (Phase 2)	Mar 15, 2019	Stanford University
NCT03772990	Phase 4	Jan 14, 2019	Moscow State University, Vita-Salute University of Milano. Italy
NCT03719001	Early Phase 1 (Phase 1)	Oct 23, 2018	University of California, San Francisco
NCT03771170	Phase 4	Jan 10, 2018	Yuria-Pharm
NCT03824457	Phase 4	Jan 8, 2018	Yuria-Pharm
NCT03133767	Phase 4	May 1, 2017	University of Iowa
NCT04152096	Phase 4	Jan 24, 2017	Yuria-Pharm
NCT02950753	Early Phase 1 (Phase 1)	Jan 4, 2017	University Medical Center of Southern Nevada
NCT03764085	Phase 4	Dec 6, 2016	Yuria-Pharm
NCT03051269	Phase 1	May 1, 2016	University of Copenhagen
NCT02580604	Early Phase 1 (Phase 1)	Nov 1, 2015	University of Colorado, Denver
NCT02461329	N/A	May 1, 2015	Masaryk University, University Hospital Brno

Showing 20 of 26 trials

Page 1 / 2

Organizations

Research & Development (27)

Organization	Org type	Trials	As lead sponsor	Phases	Earliest year
Yuria-Pharm	For profit	4	4	1	2016
Stanford University	Academic/Hospital	3	3	3	2019
University of Copenhagen	Academic/Hospital	3	3	2	2013
Aarhus University	Academic/Hospital	1	1	1	2020
Central Denmark Region	Academic/Hospital	1	0	1	2020
Harvard University	Academic/Hospital	1	1	1	2009
Helwan University	Academic/Hospital	1	1	1	2024
Humboldt University	Academic/Hospital	1	1	1	2009
Icahn School of Medicine at Mount Sinai	Academic/Hospital	1	1	1	2025
Istanbul University	Academic/Hospital	1	0	1	2024
Masaryk University	Academic/Hospital	1	0	1	2015
Mirai Medical, Ireland	Academic/Hospital	1	0	1	2020
Moscow State University	Academic/Hospital	1	1	1	2019
Mount Sinai Hospital, Canada	Academic/Hospital	1	0	1	2025
Palacky University	Academic/Hospital	1	1	1	2014
Replicon Health Oy	Academic/Hospital	1	1	1	2019
Sealantium Medical Ltd.	For profit	1	1	1	2020
Shahid Beheshti University of Medical Sciences	Academic/Hospital	1	0	1	2015
University Hospital Brno	Academic/Hospital	1	1	1	2015
University Medical Center of Southern Nevada	Academic/Hospital	1	1	1	2017

27 organizations

Page 1 / 2

Marketing (65)

Organization	Org type	Relationship	Date
Abbott	For profit	NDA2	—
Abraxis	For profit	MKTG	Jun 13, 1986
Accord Research	For profit	MKTG	Apr 30, 2007
Akorn, Inc.	For profit	MKTG	Nov 27, 1991
Akorn, Inc.	For profit	NDA2	Nov 27, 1991
Alcon	For profit	MKTG	Jul 24, 2008
Alcon	For profit	SYN	Oct 28, 1981
Alembic	For profit	MKTG	Jun 3, 2024
Amneal Pharmaceuticals	For profit	MKTG	Dec 22, 2017
Amneal Pharmaceuticals	For profit	SYN	Jul 8, 2024
Azurity	For profit	MKTG	Apr 25, 2017
B. Braun	For profit	MKTG	Feb 8, 1978
B. Braun	For profit	NDA2	Feb 8, 1978
Barr Laboratories	For profit	MKTG	Oct 15, 1990
Baxalta	For profit	SYN	Oct 25, 2006
Baxalta	For profit	MKTG	Mar 22, 1971
Baxalta	For profit	NDA2	Oct 25, 2006
Baxter	For profit	NDA2	Mar 22, 1971
Baxter	For profit	MKTG	Apr 21, 2000
Baxter	For profit	NDA	Mar 22, 1971
Bristol-Myers	For profit	MKTG	Sep 5, 1979
Bristol-Myers Squibb	For profit	MKTG	Feb 14, 1985
Bristol-Myers Squibb	For profit	SYN	Apr 14, 1989
DAVA Pharmaceuticals	For profit	MKTG	Dec 7, 1953
Daiichi Sankyo	For profit	MKTG	Jul 27, 2017
Daito Pharmaceuticals	For profit	MKTG	Aug 7, 2023
Duramed Research	For profit	MKTG	Jun 17, 1999
EXTROVIS	For profit	MKTG	Mar 29, 2012
Elite Laboratories, Inc	For profit	MKTG	May 16, 2024
Epic Pharma Llc	For profit	NDA2	Nov 27, 1991
Eugia Pharma	For profit	MKTG	Jan 30, 2020
Eugia Pharma	For profit	SYN	Mar 29, 2012
Fresenius	For profit	NDA2	Aug 25, 2014
Fresenius	For profit	MKTG	Jun 13, 1994
Fresenius	For profit	SYN	Sep 3, 1980
Hikma	For profit	MKTG	Aug 1, 1994
Hikma	For profit	SYN	Sep 16, 1986
Hospira	For profit	NDA2	Jan 15, 1980
Hospira	For profit	MKTG	Nov 7, 1988
ICU Medical Inc	For profit	MKTG	Aug 13, 1975
ICU Medical Inc	For profit	NDA2	Aug 13, 1975
International Medication	For profit	MKTG	May 9, 2018
Lotus Pharmaceutical	For profit	MKTG	Apr 23, 2021
Lukare Medical	For profit	MKTG	Sep 27, 1996
Lukare Medical	For profit	NDA2	Sep 27, 1996
Lutipold	For profit	MKTG	Jul 27, 2017
Medefil	For profit	MKTG	May 1, 2019
Miles	For profit	NDA2	—
Mylan	For profit	MKTG	May 15, 1992
Mylan	For profit	SYN	Mar 29, 2012
Nestle	For profit	NDA2	Oct 28, 1981
Norbrook	For profit	MKTG	May 9, 1986
Pharmachemie Bv	For profit	MKTG	Jan 8, 2010
Pharmachemie Bv	For profit	SYN	Jul 8, 1988
Pharmacia & Upjohn	For profit	MKTG	Aug 23, 1991
Sagent Pharmaceuticals, Inc.	For profit	MKTG	Aug 9, 2018
Sandoz	For profit	MKTG	Mar 31, 2009
Sandoz	For profit	SYN	Mar 31, 2009
Sankyo	For profit	MKTG	Jul 27, 2017
Silvergate Pharmaceuticals	For profit	MKTG	Apr 25, 2017
Somerset Pharmaceuticals	For profit	MKTG	Dec 17, 2024
Strides Pharma Science	For profit	MKTG	Dec 7, 1953
Sun Pharmaceuticals	For profit	MKTG	May 21, 2015
West-Ward Pharmaceutical	For profit	MKTG	Sep 16, 1986
Zydus Discovery DMCC	For profit	MKTG	Jan 13, 2017