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Leukomalacia, Periventricular
Degeneration of white matter adjacent to the CEREBRAL VENTRICLES following cerebral hypoxia or BRAIN ISCHEMIA in neonates. The condition primarily affects white matter in the perfusion zone between superficial and deep branches of the MIDDLE CEREBRAL ARTERY. Clinical manifestations include VISION DISORDERS; CEREBRAL PALSY; PARAPLEGIA; SEIZURES; and cognitive disorders. (From Adams et al., Principles of Neurology, 6th ed, p1021; Joynt, Clinical Neurology, 1997, Ch4, pp30-1)
Drugs by status
Phase 4 trials (1)
Phase 3 trials (6)
Organizations
Organization Involved with Phase 4 Indications (2)
Organization Involved with Phase 3 Indications (11)
- National Institutes of Health (NIH)
- National Institute of Neurological Disorders and Stroke (NINDS)
- Shaanxi Provincial People's Hospital
- University of Chicago
- Jiao Tong University
- University of Alabama, Birmingham
- George Washington University
- Xi'an Medical University
- Government of Brazil
- People's Liberation Army of China
- Oswaldo Cruz Foundation
Organization Involved with Phase 2 Indications (8)