sodium glycerophosphate pentahydrate
Trade name: Glycophos
Approved
Aug 25, 2014
Synthetic glycerophosphates have been known for many years and have been prepared in several ways. The acid may exist in two isomeric forms, alpha and beta. The L-a-acid is the naturally occurring form; the b-acid, present in hydrolyzates of lecithins from natural sources, arises from migration of the phosphoryl group from the a-carbon atom. Dehydrogenation of L-glycerol 3-phosphate produces Dihydroxyacetone phosphate and is part of the entry of glycerol (sourced from triglycerides) into the glycolytic pathway. — NCATS
Clinical trial activity
5 trials · 7 clinical orgs · 1 marketing orgs
Earliest trial started Apr 30, 2008 (NCT01264588)
Timeline
Indications
Approved for
Studied for
Mechanism of action
- UnclearUnclear
Unclear unclear
Combination products
kabiven
with soybean oil, potassium chloride, magnesium sulfate, sodium acetate, amino acids, calcium chloride, glucose monohydrate
Also known as perikabiven
Approval history
- approvedAug 25, 2014
Chemistry & pharmacology
SMILES
O=P(O)(O)OCC([O-])C[O-].[Na+].[Na+]- Mol. weight
- 216.04 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
- Delivery
- Parenteral
- Availability
- Prescription Only
Oral
No
Parenteral
Yes
Topical
No
Sources
- ChEMBLCHEMBL3040581 ↗
- NCATSRCS9EQ01V4 ↗
- ChEMBLCHEMBL6067979 ↗
- ChEMBLCHEMBL3039567 ↗
- ChEMBLCHEMBL1232903 ↗
Also known as
- 1,2,3-propanetriol, mono(dihydrogen phosphate), disodium salt, hydrate
- 1,2,3-propanetriol, mono(dihydrogen phosphate), disodium salt, hydrate
- 1-phosphoglycerol
- alpha-glycerophosphate
- alpha-glycerophosphoric acid
- alpha-glycerophosphoric acid, 1,2,3-propanetriol-1-(18)o,3-(dihydrogen phosphate)-labeled
- alpha-glycerophosphoric acid, 1,2,3-propanetriol-2-(18)o,3-(dihydrogen phosphate)-labeled
- alpha-glycerophosphoric acid, calcium salt
- alpha-glycerophosphoric acid, disodium salt
- alpha-glycerophosphoric acid, disodium salt hexahydrate(+-)-isomer
- alpha-glycerophosphoric acid, disodium salt (+-)-isomer
- alpha-glycerophosphoric acid, (dl)-isomer
- alpha-glycerophosphoric acid, fe(+3) salt (3:2)
- alpha-glycerophosphoric acid, fe salt
- alpha-glycerophosphoric acid, monocalcium salt
- alpha-glycerophosphoric acid, monocalcium salt (s)-isomer
- alpha-glycerophosphoric acid, monomagnesium salt
- alpha-glycerophosphoric acid, (r)-isomer
- alpha-glycerophosphoric acid, (s)-isomer
- alpha-glycerophosphoric acid, sodium salt
- disodium glycerophosphate
- glycerol 1-phosphate
- glycerol 3-phosphate
- glycerol phosphate disodium salt hydrate
- glycerophosphate
- glycerophosphate
- glycerophosphate disodium salt hydrate
- glycerophosphate disodium salt hydrate
- glycerophosphoric acid
- glycerophosphoric acid
- glycophos
- sodium glycerophosphate
- sodium glycerophosphate
- sodium glycerophosphate
- sodium glycerophosphate
- sodium glycerophosphate
- sodium glycerophosphate
- sodium glycerophosphate anhydrous
- sodium glycerophosphate hydrate
- sodium glycerophosphate hydrate
- sodium glycerophosphate pentahydrate
- sodium glycerophosphate pentahydrate
- sodium glycerophosphate pentahydrate
- sodium glycerophosphate pentahydrate
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06842121 | Phase 1 | Jan 27, 2025 | Baxalta |
| NCT06842134 | Phase 1 | Jan 27, 2025 | Baxalta |
| NCT07060859 | N/A | Jan 15, 2023 | Al Azhar University |
| NCT05682846 | N/A | May 1, 2022 | Alexandria University |
| NCT01264588 | N/A | Apr 30, 2008 | AkPharma Inc., Cyberderm Inc., Texas Tech University, Thomas Jefferson University |
Organizations
Research & Development (7)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Baxalta | For profit | 2 | 2 | 1 | 2025 |
| AkPharma Inc. | For profit | 1 | 1 | 1 | 2008 |
| Al Azhar University | Academic/Hospital | 1 | 1 | 1 | 2023 |
| Alexandria University | Academic/Hospital | 1 | 1 | 1 | 2022 |
| Cyberderm Inc. | For profit | 1 | 0 | 1 | 2008 |
| Texas Tech University | Academic/Hospital | 1 | 0 | 1 | 2008 |
| Thomas Jefferson University | Academic/Hospital | 1 | 0 | 1 | 2008 |