CDEK
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probenecid

Trade name: colbenemid

Small moleculeapproved

Approved

Apr 26, 1951

Probenecid, also sold under the brand name Probalan, is a medication that increases uric acid excretion in the urine. It is primarily used in treating gout and hyperuricemia. — Wikipedia

Clinical trial activity

29 trials · 25 clinical orgs · 15 marketing orgs

Phase 1
18
Phase 2
8
Phase 3
7
Phase 4
1

Earliest trial started Mar 21, 2017 (NCT03965351)

Timeline

1950s

  1. Apr 26, 1951

    Earliest FDA Approval

  2. Apr 26, 1951

    Merck — NDA Secondary Org

1960s

  1. Jul 27, 1961

    Merck — First NDA Organization

  2. Jul 27, 1961

    Merck — NDA Organization

1970s

  1. Oct 10, 1973

    Cosette — Marketing Organization

  2. Dec 16, 1974

    Apothecon — Marketing Organization

  3. Apr 7, 1975

    Watson Pharmaceuticals — Marketing Organization

  4. Jan 13, 1976

    Aurobindo Pharma — Marketing Organization

  5. Mar 11, 1976

    Beecham — Marketing Organization

  6. Jul 29, 1976

    Lannett Company, Inc. — Marketing Organization

  7. Jun 12, 1978

    Ani Pharmaceuticals — Marketing Organization

  8. Sep 6, 1979

    Lederle — Marketing Organization

1980s

  1. Mar 18, 1980

    Sandoz — Marketing Organization

  2. May 9, 1984

    Teva — Marketing Organization

2000s

  1. May 13, 2008

    Novast Labs — Marketing Organization

  2. May 13, 2008

    Ingenus Pharmaceuticals — Marketing Organization

2010s

  1. Jan 1, 2017

    Earliest Phase 1 Sponsor(trial)

  2. Jan 1, 2018

    Iterum Therapeutics — Earliest Phase 3 Sponsor(trial)

2020s

  1. Jan 1, 2021

    Earliest Phase 2 Sponsor(trial)

  2. Oct 24, 2023

    Rising Pharmaceuticals — Marketing Organization

  3. Oct 25, 2024

    Iterum Therapeutics — NDA Secondary Org

Indications

Approved for

Studied for

Mechanism of action

  • Uric acidSEQUESTERING AGENT

    Uric acid sequestering agent

Combination products

Approval history

  • approvedPriority reviewApr 26, 1951

Chemistry & pharmacology

Loading structure…

SMILES

CCCN(CCC)S(=O)(=O)c1ccc(C(=O)O)cc1
Mol. weight
285.37 g/mol
Lipinski Ro5
Pass
Rule of 3
No
Chirality
Achiral Molecule
Inorganic
No
Polymer
No
Delivery
Oral
Availability
Prescription Only

Oral

Yes

Parenteral

No

Topical

No

Sources

Also known as

  • colbenemid
  • colbenemid

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT07118618Phase 2Nov 30, 2025Brown University
NCT07160738Phase 1Sep 22, 2025Pfizer
NCT06647810Phase 1Nov 13, 2024Boehringer Ingelheim
NCT06416800Phase 1Jun 19, 2024Incyte
NCT05903859Phase 3Jan 1, 2024Department of Defense, University of Miami
NCT06025344Phase 1Dec 31, 2023TrippBio, Inc.
NCT06025318Phase 1Dec 31, 2023TrippBio, Inc.
NCT05954624Phase 1Jul 10, 2023Guangdong Raynovent Biotech Co., Ltd
NCT05881811Phase 1Mar 20, 2023Haisco Pharmaceutical
NCT05584657Phase 3Oct 18, 2022Iterum Therapeutics
NCT05618314Phase 1Oct 17, 2022Atea Pharmaceuticals, Inc.
NCT05442983Phase 2Jul 12, 2022TrippBio, Inc.
NCT05497674Phase 1Feb 21, 2022Sunshine Lake Pharma Co., Ltd.
NCT05280054Phase 1Dec 23, 2021Parexel, VistaGen Therapeutics, Inc.
NCT05082909Phase 1/Phase 2 (Phase 2)Oct 31, 2021Imperial College London
NCT05045313Phase 1Sep 30, 2021Shijiazhuang Pharma Group (CSPC)
NCT04939623Phase 2/Phase 3 (Phase 3)Sep 2, 2021University of Calgary
NCT04551222Phase 2/Phase 3 (Phase 3)Feb 1, 2021Department of Veteran Affairs
NCT04218357Phase 1Feb 2, 2020Brown University
NCT03937258Phase 1May 21, 2019Pfizer
Showing 20 of 29 trials
Page 1 / 2

Organizations

Research & Development (25)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Iterum TherapeuticsFor profit5522018
TrippBio, Inc.For profit3322022
Boehringer IngelheimFor profit2212017
Brown UniversityAcademic/Hospital2222020
PfizerFor profit2212019
Akebia TherapeuticsFor profit1112018
American Heart AssociationAcademic/Hospital1012017
Atea Pharmaceuticals, Inc.For profit1112022
Department of DefenseGovernment1012024
Department of Veteran AffairsGovernment1112021
Guangdong Raynovent Biotech Co., LtdFor profit1112023
Haisco PharmaceuticalFor profit1112023
Harvard UniversityAcademic/Hospital1012017
Imperial College LondonAcademic/Hospital1112021
IncyteFor profit1112024
Novo NordiskFor profit1112018
ParexelFor profit1012021
Shijiazhuang Pharma Group (CSPC)For profit1112021
Sponsor GmbHAcademic/Hospital1012018
Sunshine Lake Pharma Co., Ltd.For profit1112022
25 organizations
Page 1 / 2

Marketing (17)

OrganizationOrg typeRelationshipDate
Ani PharmaceuticalsFor profitMKTGJun 12, 1978
ApotheconFor profitMKTGDec 16, 1974
Aurobindo PharmaFor profitMKTGJan 13, 1976
BeechamFor profitMKTGMar 11, 1976
CosetteFor profitMKTGOct 10, 1973
Ingenus PharmaceuticalsFor profitMKTGMay 13, 2008
Iterum TherapeuticsFor profitNDA2Oct 25, 2024
Lannett Company, Inc.For profitMKTGJul 29, 1976
LederleFor profitMKTGSep 6, 1979
MerckFor profitNDAJul 27, 1961
MerckFor profitNDA2Apr 26, 1951
Novast LabsFor profitMKTGMay 13, 2008
Rising PharmaceuticalsFor profitMKTGOct 24, 2023
SandozFor profitMKTGMar 18, 1980
TevaFor profitMKTGMay 9, 1984
TevaFor profitSYNMar 2, 1977
Watson PharmaceuticalsFor profitMKTGApr 7, 1975