padsevonil
Small moleculeexperimental
Clinical trial activity
15 trials · 3 clinical orgs · 0 marketing orgs
Phase 1
10
Phase 2
4
Phase 3
2
Phase 4
0
Earliest trial started Jul 1, 2015 (NCT02495844)
Timeline
Indications
Mechanism of action
- GABA-A receptor alpha-1/beta-3INHIBITOR
GABA-A receptor alpha-1/beta-3 inhibitor
- GABA-A receptor; anion channelPARTIAL AGONIST
GABA-A receptor; anion channel partial agonist
BZD site
- Gamma-aminobutyric acid receptor subunit alpha-1 (GABRA1) ↗
- Gamma-aminobutyric acid receptor subunit beta-2 (GABRB2) ↗
- Gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2) ↗
- Gamma-aminobutyric acid receptor subunit beta-3 (GABRB3) ↗
- Gamma-aminobutyric acid receptor subunit alpha-4 (GABRA4) ↗
- Gamma-aminobutyric acid receptor subunit gamma-3 (GABRG3) ↗
- Gamma-aminobutyric acid receptor subunit theta (GABRQ) ↗
- Gamma-aminobutyric acid receptor subunit alpha-3 (GABRA3) ↗
- Gamma-aminobutyric acid receptor subunit pi (GABRP) ↗
- Gamma-aminobutyric acid receptor subunit delta (GABRD) ↗
- Gamma-aminobutyric acid receptor subunit gamma-1 (GABRG1) ↗
- Gamma-aminobutyric acid receptor subunit beta-1 (GABRB1) ↗
- Gamma-aminobutyric acid receptor subunit epsilon (GABRE) ↗
- Gamma-aminobutyric acid receptor subunit alpha-2 (GABRA2) ↗
- Gamma-aminobutyric acid receptor subunit alpha-5 (GABRA5) ↗
- Gamma-aminobutyric acid receptor subunit alpha-6 (GABRA6) ↗
- GABA receptor alpha-1 subunit
- GABA receptor beta-2 subunit
- GABA receptor alpha-4 subunit
- GABA receptor delta subunit
- GABA receptor alpha-5 subunit
- GABA receptor alpha-6 subunit
- GABA receptor beta-3 subunit
- GABA receptor alpha-3 subunit
- GABA receptor alpha-2 subunit
- GABA-A receptor; GABA-A site (alpha1/beta2 interface)
- GABA-A receptor; alpha-3/beta-3/gamma-2
- GABA-A receptor; alpha-1/beta-3/gamma-2
- GABA-A receptor; alpha-5/beta-3/gamma-2
- GABA-A receptor; alpha-2/beta-3/gamma-2
- GABA-A receptor; alpha-1/beta-2/gamma-2
- GABA-A receptor; alpha-6/beta-3/gamma-2
- GABA-A receptor; benzodiazepine site
- GABA-A receptor; agonist GABA site
- GABA A receptor alpha-2/beta-2/gamma-2
- GABA A receptor alpha-3/beta-2/gamma-2
- GABA A receptor alpha-6/beta-2/gamma-2
- GABA A receptor alpha-1/beta-1/gamma-2
- GABA A receptor alpha-4/beta-3/gamma-2
- Gamma-aminobutyric acid receptor subunit alpha-4/beta3/delta
- Gamma-aminobutyric acid receptor subunit alpha-1/ beta-1
- Gamma-aminobutyric acid receptor subunit alpha-2/beta-2
- Gamma-aminobutyric acid receptor subunit alpha-3/ beta-2
- Gamma-aminobutyric acid receptor subunit alpha-3/ beta-3/gamma-3
- Gamma-aminobutyric acid receptor subunit alpha-3/beta-3
- Gamma-aminobutyric acid receptor subunit alpha-3/beta-3/theta
- Gamma-aminobutyric acid receptor subunit alpha-5/beta-2
- Gamma-aminobutyric acid receptor subunit alpha-5/beta-3/gamma-3
- Gamma-aminobutyric acid receptor subunit alpha-6/beta-3
- GABA-A receptor alpha-1/beta-3
- Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/delta
- Gamma-aminobutyric acid receptor subunit alpha-4/beta-2/delta
- Gamma-aminobutyric acid receptor subunit beta-1/beta-2
- Gamma-aminobutyric acid receptor subunit alpha-5/beta-3
- Gamma-aminobutyric acid receptor subunit alpha-2/beta-3
- Gamma-aminobutyric acid receptor subunit alpha-1/alpha-2/beta-2/gamma-2
- Gamma-aminobutyric acid receptor subunit alpha-1/gamma-2
- Gamma-aminobutyric acid receptor subunit alpha-4/beta-2/gamma-2
- Gamma-aminobutyric acid receptor subunit alpha-4/beta-1/delta
- Gamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-2
- GABA receptor beta-1 subunit
- Gamma-aminobutyric acid receptor subunit alpha-2/beta-1/gamma-2
- Synaptic vesicle proteinMODULATOR
Synaptic vesicle protein modulator
Chemistry & pharmacology
Loading structure…
SMILES
COCc1nn2c(CN3C[C@@H](CC(F)(F)Cl)CC3=O)c(C(F)(F)F)nc2s1- Mol. weight
- 432.8 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL4297521 ↗
Also known as
- ucb0942
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT04283136 | Phase 1 | Feb 24, 2020 | UCB |
| NCT04136444 | Phase 1 | Oct 31, 2019 | UCB |
| NCT04131517 | Phase 1 | Oct 31, 2019 | UCB |
| NCT04126343 | Phase 1 | Oct 31, 2019 | UCB |
| NCT04075409 | Phase 1 | Oct 31, 2019 | UCB |
| NCT04039919 | Phase 1 | Aug 31, 2019 | UCB |
| NCT04013191 | Phase 1 | Jul 31, 2019 | UCB |
| NCT03739840 | Phase 3 | Mar 6, 2019 | UCB |
| NCT03695094 | Phase 1 | Sep 18, 2018 | UCB |
| NCT03370120 | Phase 2/Phase 3 (Phase 3) | Aug 27, 2018 | UCB |
| NCT03480243 | Phase 1 | Mar 27, 2018 | UCB |
| NCT03373383 | Phase 2 | Feb 12, 2018 | UCB |
| NCT03168984 | Phase 1 | May 5, 2017 | Hoosier Cancer Research Network |
| NCT02625090 | Phase 2 | Sep 1, 2015 | Hoosier Cancer Research Network |
| NCT02495844 | Phase 2 | Jul 1, 2015 | Hoosier Cancer Research Network, Pharmaceutical Research Associates, Inc. (PRA) |
Showing 15 of 15 trials
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Organizations
Research & Development (3)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| UCB | For profit | 12 | 12 | 3 | 2018 |
| Hoosier Cancer Research Network | Academic/Hospital | 3 | 3 | 2 | 2015 |
| Pharmaceutical Research Associates, Inc. (PRA) | For profit | 1 | 0 | 1 | 2015 |
3 organizations
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