halazepam

Trade name: paxipam

Small moleculeapproved

Approved

Sep 24, 1981

Halazepam is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. Halazepam is used to relieve anxiety, nervousness, and tension associated with anxiety disorders. Halazepam (Paxipam) is no longer commercially available in the United States. Common adverse effects are: hypotension, nausea, xerostomia, confusion, headache. Alcohol should be avoided while taking Paxipam as it causes drowsiness as well. Medications that also cause drowsiness should not be taken along with Paxipam. These include: Antidepressants, Pain relievers, Seizure medications, Muscle relaxants, Antihistamines, Sleeping pills and sedatives. — NCATS

Clinical trial activity

0 trials · 0 clinical orgs · 2 marketing orgs

Phase 1
0
Phase 2
0
Phase 3
0
Phase 4
0

Timeline

1980s

  1. Sep 24, 1981

    Schering-Plough — Earliest FDA Approval

  2. Sep 24, 1981

    Schering-Plough — NDA Organization

  3. Sep 24, 1981

    Schering — NDA Secondary Org

  4. Sep 24, 1981

    Schering-Plough — NDA Secondary Org

Indications

Mechanism of action

Approval history

  • approvedSep 24, 1981

Chemistry & pharmacology

Loading structure…

SMILES

FC(F)(F)CN1C2=CC=C(Cl)C=C2C(=NCC1=O)C3=CC=CC=C3
Mol. weight
352.738 g/mol
Lipinski Ro5
Pass
Rule of 3
No
Chirality
Achiral Molecule
Inorganic
No
Polymer
No
Delivery
Oral
Availability
Discontinued

Oral

Yes

Parenteral

No

Topical

No

Sources

Also known as

  • 7-chloro-1,3-dihydro-5-phenyl-1- (2,2,2-trifluoroethyl)-2h-1,4-benzodiazepin-2-one
  • halazepam
  • halazepam
  • halazepam
  • halazepam
  • halazepam
  • halazepam
  • halazepam
  • halazepam
  • halazepam
  • halazepam
  • halazepam
  • halazépam
  • halazépam
  • halazepamum
  • halazepamum
  • paxipam
  • paxipam
  • paxipam
  • paxipam
  • sch 12041
  • sch-12041
  • sch-12041

Organizations

Marketing (3)

OrganizationOrg typeRelationshipDate
ScheringFor profitNDA2Sep 24, 1981
Schering-PloughFor profitNDASep 24, 1981
Schering-PloughFor profitNDA2Sep 24, 1981