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talbutal

Trade name: lotusate

Small moleculeapproved

Approved

Sep 21, 1954

Talbutal is a short to intermediate-acting barbiturate, which had been used under brand name Latusate as a sedative and hypnotic, but then this usage was discontinued. It was found, that talbutal binds at a distinct binding site at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. Thus, the post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged. — NCATS

Clinical trial activity

0 trials · 0 clinical orgs · 2 marketing orgs

Phase 1
0
Phase 2
0
Phase 3
0
Phase 4
0

Timeline

1950s

  1. Jun 1, 1954

    Sterling-Winthrop — First NDA Organization

  2. Jun 1, 1954

    Sterling-Winthrop — NDA Organization

  3. Sep 21, 1954

    Earliest FDA Approval

  4. Sep 21, 1954

    Sanofi-Aventis — Marketing Organization

  5. Sep 21, 1954

    Sanofi-Aventis — NDA Secondary Org

Indications

Approved for

Mechanism of action

Approval history

  • approvedSep 21, 1954

Chemistry & pharmacology

Loading structure…

SMILES

CCC(C)C1(CC=C)C(=O)NC(=O)NC1=O
Mol. weight
224.2563 g/mol
Lipinski Ro5
Pass
Rule of 3
No
Chirality
Racemic Mixture
Inorganic
No
Polymer
No
Delivery
Oral
Availability
Discontinued

Oral

Yes

Parenteral

No

Topical

No

Sources

Also known as

  • 5-allyl-5-(1-methylpropyl) barbituric acid
  • 5-allyl-5-sec-butylbarbituric acid
  • 5-allyl-5-sec-butylbarbituric acid
  • 5-allyl-5-sec-butylbarbituric acid
  • 5-allyl-5-sec-butylbarbituric acid
  • allyl-sec-butyl-barbituric acid
  • lotusate
  • lotusate
  • lotusate
  • lotusate
  • lotusate
  • profundol
  • profundol
  • profundol
  • profundol
  • profundol
  • (rs)-5-allyl-5-sec-butylpyrimidine-2,4,6(1h,3h,5h)-trione
  • (rs)-5-allyl-5-sec-butylpyrimidine-2,4,6(1h,3h,5h)-trione
  • sec-butyl allyl barbituric acid
  • talbutal
  • talbutal
  • talbutal
  • talbutal
  • talbutal
  • talbutal
  • talbutal
  • talbutal
  • talbutal
  • talbutal
  • talbutale
  • talbutale
  • talbutalum
  • talbutalum

Organizations

Marketing (3)

OrganizationOrg typeRelationshipDate
Sanofi-AventisFor profitMKTGSep 21, 1954
Sanofi-AventisFor profitNDA2Sep 21, 1954
Sterling-WinthropFor profitNDAJun 1, 1954