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triclofos

Trade name: triclos

Small moleculeapproved

Triclofos is primarily indicated in conditions like Insomnia, and can also be given in adjunctive therapy as an alternative drug of choice in Nausea, vertigo, labyrinthine disorders. It is also used sedate people suffering from anxiety or tension before medical investigations. Triclofos is converted to Trichloroethanol in the body .This act on brain and produces sleep. Trichloroethanol decreases time taken to fall asleep and lengthen the sleep. Triclofos is most commonly used agent for sedation in neonates as well as in older infants and children in Japan. — NCATS

Clinical trial activity

1 trials · 1 clinical orgs · 2 marketing orgs

Phase 1
0
Phase 2
0
Phase 3
0
Phase 4
1

Earliest trial started Mar 1, 2020 (NCT04270708)

Timeline

1970s

  1. Jun 1, 1971

    Merrell Dow — First NDA Organization

  2. Jun 1, 1971

    Merrell Dow — NDA Organization

Indications

Approved for

Studied for

Mechanism of action

Approval history

  • approved—

Chemistry & pharmacology

Loading structure…

SMILES

O=P(O)(O)OCC(Cl)(Cl)Cl
Mol. weight
229.38 g/mol
Lipinski Ro5
Pass
Rule of 3
No
Chirality
Achiral Molecule
Inorganic
No
Polymer
No
Delivery
Oral
Availability
Discontinued

Oral

Yes

Parenteral

No

Topical

No

Sources

Also known as

  • 2,2,2-trichloroethanol, dihydrogen phosphate
  • 2,2,2-trichloroethyl dihydrogen phosphate, sodium salt
  • 2,2,2-trichloroethyl phosphate
  • monosodium trichloroethyl phosphate
  • sch-10159
  • sch-10159
  • trichlophos
  • trichloroethyl dihydrogen phosphate
  • trichloroethyl phosphate
  • trichloroethyl phosphate sodium
  • trichloroethyl phosphate sodium
  • triclofos
  • triclofos
  • triclofos
  • triclofos
  • triclofos
  • triclofos
  • triclofos
  • triclofos
  • triclofos, monosodium salt
  • triclofos sodium
  • triclofos sodium
  • triclofos sodium
  • triclofos sodium
  • triclos
  • triclos
  • triclos

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT04270708Phase 4Mar 1, 2020Tel Aviv University
Showing 1 of 1 trials
Page 1 / 1

Organizations

Research & Development (1)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Tel Aviv UniversityAcademic/Hospital1112020
1 organizations
Page 1 / 1

Marketing (2)

OrganizationOrg typeRelationshipDate
Merrell DowFor profitNDAJun 1, 1971
Sanofi-AventisFor profitNDA2—