etifoxine

Trade name: Stresam

Small moleculeexperimental

Etifoxine, sold under the trade name Stresam among others, is a nonbenzodiazepine anxiolytic agent, primarily indicated for short-term management of adjustment disorder, specifically instances of situational depression accompanied by anxiety, such as stress-induced anxiety. Administration is by mouth. Side effects associated with etifoxine use include slight drowsiness, headache, skin eruptions, and allergic reactions. In rare cases, etifoxine has been linked to severe skin and liver toxicity, as well as menstrual bleeding between periods. Unlike benzodiazepines, etifoxine does not cause sedation or lack of coordination. Etifoxine acts as a ligand for translocator proteins. — Wikipedia

Clinical trial activity

3 trials · 2 clinical orgs · 0 marketing orgs

Phase 1
0
Phase 2
2
Phase 3
2
Phase 4
0

Earliest trial started Dec 1, 2013 (NCT02143895)

Timeline

2010s

  1. Jan 1, 2013

    Earliest Phase 3 Sponsor(trial)

Indications

Mechanism of action

Chemistry & pharmacology

Loading structure…

SMILES

CCNC1=Nc2ccc(Cl)cc2C(C)(c2ccccc2)O1
Mol. weight
300.79 g/mol
Lipinski Ro5
Pass
Rule of 3
No
Chirality
Racemic Mixture
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • 2-ethylamino-6-chloro-4-methyl-4-phenyl-4h-3,1-benzoxazine
  • 36-801
  • etafenoxine
  • etafenoxine
  • etafenoxine hydrochloride
  • etafenoxine hydrochloride
  • etifoxin
  • etifoxin
  • etifoxine
  • etifoxine
  • etifoxine
  • etifoxine
  • etifoxine
  • etifoxine
  • etifoxine
  • etifoxine
  • etifoxine hydrochloride
  • etifoxine hydrochloride
  • etifoxine hydrochloride
  • etifoxine hydrochloride
  • etifoxine hydrochloride
  • etifoxine hydrochloride
  • hoe 36801
  • hoe-36801
  • hoe-36801
  • stresam

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT03850301N/AApr 1, 2018Imperial College London
NCT02143895Phase 3Dec 1, 2013Biocodex
NCT02147548Phase 3Dec 1, 2013Biocodex
Showing 3 of 3 trials
Page 1 / 1

Organizations

Research & Development (2)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
BiocodexFor profit2212013
Imperial College LondonAcademic/Hospital1112018
2 organizations
Page 1 / 1