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Clostridioides difficile

A common inhabitant of the colon flora in human infants and sometimes in adults. The type species Clostridioides difficile is formerly known as Clostridium difficile. It is a causative agent for CLOSTRIDIOIDES INFECTIONS and is associated with PSEUDOMEMBRANOUS ENTEROCOLITIS in patients receiving antibiotic therapy.

Drugs by status

Approved for this indication (1)

  • autologous microbiome

Phase 4 trials (8)

  • metronidazole
  • fidaxomicin
  • vancomycin
  • bezlotoxumab
  • chlorhexidine
  • omeprazole
  • loperamide
  • lactobacillus rhamnosus

Phase 3 trials (10)

  • tolevamer
  • whey protein
  • lactobacillus gasseri
  • saccharomyces boulardii
  • bifidobacterium bifidum
  • bifidobacterium longum
  • human fecal microbiota
  • cp101
  • ve303
  • polyethylene glycol

Phase 2 trials (11)

  • dipeptide alanyl-glutamine
  • intestinal microbiota
  • nitazoxanide
  • Firmicutes spores
  • syn-004
  • vla84
  • c. difficile toxoid vaccine
  • microbiota
  • misoprostol
  • lyophilized sterile fecal filtrate
  • lactobacillus delbrueckii

Phase 1 trials (2)

  • spirulina
  • Methlythioninium

Other trials (8)

  • bovine colostrum
  • tigecycline
  • lactoferrin
  • ciprofloxacin
  • lactobacillus plantarum
  • clindamycin
  • potato starch
  • lactobacillus reuteri

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