lactobacillus delbrueckii
Cell therapyexperimental
Lactobacillus bulgaricus is the main bacterium used for the production of yogurt. It also plays a crucial role in the ripening of some cheeses, as well as in other processes involving naturally fermented products. It is defined as homofermentive lactic acid bacteria due to lactic acid being the single end product of its carbohydrate digestion. It is also considered a probiotic. — Wikipedia
Clinical trial activity
120 trials · 148 clinical orgs · 0 marketing orgs
Phase 1
12
Phase 2
27
Phase 3
23
Phase 4
13
Earliest trial started Dec 1, 2003 (NCT00159523)
Timeline
Indications
Approved for
Studied for
- Abdominal Injuries · Phase 2/Phase 3
- Abdominal Pain · Phase 2/Phase 3
- Acute-On-Chronic Liver Failure · Phase 2/Phase 3
- Adenomatous Polyposis Coli · Phase 2
- Angina, Stable · Phase 4
- Antibiotic Prophylaxis · Phase 2
- Anti-Infective Agents · Phase 4
- Ascites · Phase 2
- Asthma · Phase 3
- Attention · Early Phase 1
- Attention Deficit Disorder with Hyperactivity · Early Phase 1
- Binge Drinking · Phase 2
- Chronic Periodontitis · Phase 3
- Clostridioides difficile · Phase 2
- Colitis, Ulcerative · Phase 4
- Communicable Diseases · Phase 4
- Crohn Disease · Phase 4
- Defecation · Phase 2/Phase 3
- Deglutition Disorders · Early Phase 1
- Dental Caries · Phase 2/Phase 3
- Dermatology · Phase 1
- Diarrhea · Phase 4
- Diverticular Diseases · Phase 3
- Drug Resistance, Bacterial · Phase 2
- Dyspepsia · Phase 2/Phase 3
- Eczema · Phase 2
- Enterocolitis, Necrotizing · Phase 3
- Fatty Liver · Phase 1
- Gastroenteritis · Phase 4
- Gastrointestinal Diseases · Phase 3
- General Surgery · Phase 2/Phase 3
- Helicobacter · Phase 2/Phase 3
- Hepatic Encephalopathy · Phase 3
- Hirschsprung Disease · Phase 2
- Hypertension, Portal · Phase 1/Phase 2
- Impulsive Behavior · Early Phase 1
- Infant, Premature · Early Phase 1
- Infections · Phase 4
- Inflammatory Bowel Diseases · Phase 3
- Interleukin-17 · Phase 1/Phase 2
- Intestinal Neoplasms · Phase 2/Phase 3
- Irritable Bowel Syndrome · Phase 4
- Kidney Failure, Chronic · Phase 2
- Klebsiella pneumoniae · Phase 1/Phase 2
- Liver Cirrhosis · Phase 2/Phase 3
- Metabolomics · Early Phase 1
- Mucositis · Phase 4
- Myocardium · Phase 4
- Non-alcoholic Fatty Liver Disease · Phase 1/Phase 2
- Osteoporosis · Phase 2
- Peri-Implantitis · Phase 4
- Peritonitis · Phase 2/Phase 3
- Pharmacologic Actions · Phase 4
- Probiotics · Phase 4
- Respiratory Tract Infections · Phase 3
- Rhinitis, Allergic · Phase 2
- Therapeutic Uses · Phase 4
- Urinary Tract Infections · Phase 1/Phase 2
Mechanism of action
- microbiotaTissue restoration
microbiota tissue restoration
Chemistry & pharmacology
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaLactobacillus delbrueckii subsp. bulgaricus ↗
- WikipediaLactobacillus delbrueckii ↗
Also known as
- lactobacillus delbruckii lactis
- lactobacillus delbrueckii
- lactobacillus delbrueckii subsp. bulgaricus
- lactobacillus delbrueckii subspecies bulgaricus lb-51
- probiotic
- vsl #3
- vsl#3
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06658821 | N/A | Dec 1, 2024 | Chung Shan Medical University, Synbio Tech |
| NCT05467605 | N/A | Jul 31, 2022 | Cairo University |
| NCT05805488 | N/A | Oct 1, 2021 | China Medical University, TCI Co., Ltd. |
| NCT05007470 | N/A | Sep 1, 2021 | University of California, Los Angeles |
| NCT04506385 | Early Phase 1 (Phase 1) | Apr 20, 2020 | Probiotical S.p.A., University of Florence |
| NCT04167995 | Early Phase 1 (Phase 1) | Nov 9, 2019 | Ain Shams University |
| NCT04572932 | N/A | May 1, 2019 | Ain Shams University |
| NCT03940612 | N/A | May 1, 2019 | Synbio Tech, University of Science Malaysia |
| NCT04053790 | Phase 4 | Jan 15, 2019 | National Autonomous University of Mexico |
| NCT03586622 | N/A | Sep 1, 2018 | Calpro AS, Colitis-Crohn Foreningen, Ferring, Genetic Analysis, North Zealands University Hospital, Statens Serum Institut, University of Copenhagen |
| NCT03801655 | N/A | Aug 15, 2018 | University of Oxford |
| NCT03682094 | Early Phase 1 (Phase 1) | Aug 13, 2018 | University of Wisconsin |
| NCT03511365 | Phase 1/Phase 2 (Phase 2) | May 15, 2018 | Northwell Health |
| NCT03327051 | Phase 4 | Nov 30, 2017 | Stanford University |
| NCT03196453 | N/A | Aug 1, 2017 | University of Turku |
| NCT03165747 | Phase 2 | Jul 5, 2017 | Emory University |
| NCT03092427 | N/A | May 1, 2017 | University of Paris |
| NCT03052179 | N/A | May 1, 2017 | University of London |
| NCT03415711 | N/A | Apr 28, 2017 | Universita' Cattolica del Sacro Cuore, VSL Pharmaceuticals |
| NCT02568891 | Phase 2 | Jan 1, 2017 | Medical University of Graz |
Showing 20 of 120 trials
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Organizations
Research & Development (148)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| VSL Pharmaceuticals | For profit | 7 | 3 | 4 | 2004 |
| Nestle | For profit | 5 | 5 | 2 | 2007 |
| Danisco | For profit | 4 | 3 | 3 | 2011 |
| University of Copenhagen | Academic/Hospital | 4 | 4 | 1 | 2009 |
| University of London | Academic/Hospital | 4 | 4 | 3 | 2007 |
| University of Wisconsin | Academic/Hospital | 4 | 4 | 3 | 2008 |
| Ain Shams University | Academic/Hospital | 2 | 2 | 2 | 2019 |
| All India Institute of Medical Sciences | Academic/Hospital | 2 | 1 | 1 | 2007 |
| Biopolis S.L. | For profit | 2 | 2 | 1 | 2015 |
| CD Pharma India Pvt. Ltd. | For profit | 2 | 2 | 1 | 2009 |
| China Medical University | Academic/Hospital | 2 | 1 | 1 | 2011 |
| Chr Hansen | For profit | 2 | 0 | 1 | 2009 |
| Clinical Research Associates of Tidewater | For profit | 2 | 0 | 1 | 2011 |
| Ferring | For profit | 2 | 0 | 2 | 2010 |
| Hebrew University | Academic/Hospital | 2 | 2 | 2 | 2004 |
| Indian Council of Medical Research | Academic/Hospital | 2 | 0 | 2 | 2009 |
| Korott, S.L. | For profit | 2 | 0 | 1 | 2015 |
| Medical University of Graz | Academic/Hospital | 2 | 2 | 1 | 2016 |
| National University of Singapore | Academic/Hospital | 2 | 2 | 2 | 2006 |
| Next Gen Pharma India Pvt. Ltd. | For profit | 2 | 2 | 1 | 2015 |
148 organizations
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