lactoferrin
Recombinant proteinexperimental
Lactoferrin (LF), also known as lactotransferrin (LTF), is a multifunctional protein of the transferrin family. Lactoferrin is a globular glycoprotein with a molecular mass of about 80 kDa that is widely represented in various secretory fluids, such as milk, saliva, tears, and nasal secretions. Lactoferrin is also present in secondary granules of PMNs and is secreted by some acinar cells. Lactoferrin can be purified from milk or produced recombinantly. Human colostrum has the highest concentration, followed by human milk, then cow milk (150 mg/L). — Wikipedia
Clinical trial activity
64 trials · 61 clinical orgs · 0 marketing orgs
Phase 1
8
Phase 2
17
Phase 3
9
Phase 4
12
Earliest trial started Sep 1, 2004 (NCT00095186)
Timeline
Indications
Approved for
Studied for
- Acne Vulgaris · Phase 2
- Amoxicillin · Phase 4
- Anemia · Phase 1
- Anemia, Iron-Deficiency · Phase 4
- Bacterial Infections · Phase 1/Phase 2
- Carcinoma, Renal Cell · Phase 2
- Child Nutrition Disorders · Phase 3
- Cognition Disorders · Phase 2
- Coronavirus Infections · Phase 2
- COVID-19 · Phase 2/Phase 3
- Critical Illness · Phase 4
- Delivery, Obstetric · Phase 4
- Diarrhea · Phase 3
- Heart Failure, Systolic · Phase 4
- HIV Infections · Phase 2
- Infant, Low Birth Weight · Phase 4
- Infant, Premature, Diseases · Phase 4
- Infant, Very Low Birth Weight · Early Phase 1
- Inflammation · Phase 2
- Iron Deficiencies · Phase 4
- Kidney Failure, Chronic · Phase 4
- Live Birth · Phase 1
- Mycoses · Phase 1/Phase 2
- Neonatal Sepsis · Phase 4
- Postoperative Complications · Phase 4
- Pregnancy · Phase 4
- Pregnancy Complications · Phase 2
- Respiratory Distress Syndrome · Phase 2
- Sepsis · Phase 2/Phase 3
- Tooth Extraction · Phase 4
- Vagina · Phase 2/Phase 3
- Wasting Disease, Chronic · Phase 3
- Xerostomia · Phase 3
Mechanism of action
- IronCHELATING AGENT
Iron chelating agent
Chemistry & pharmacology
- Multi-specific
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaLactoferrin ↗
Also known as
- human lactoferrin
- lactoferrin
- lactoferrin
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07255742 | N/A | Aug 1, 2025 | Tanta University |
| NCT07069140 | N/A | Jul 30, 2025 | University of Pavia |
| NCT07035964 | N/A | Jun 4, 2025 | Helaina Inc., Pasteur Merieux |
| NCT06427200 | Phase 4 | Jul 31, 2024 | Cairo University |
| NCT06181422 | Phase 2/Phase 3 (Phase 3) | Jan 31, 2024 | Tanta University |
| NCT05936528 | Phase 4 | Nov 1, 2023 | — |
| NCT06012669 | N/A | Sep 6, 2023 | Helaina Inc., MB Clinical Research and Consulting LLC, Midwest Center for Metabolic and Cardiovascular Research |
| NCT05921968 | Phase 4 | Jul 30, 2023 | Ain Shams University |
| NCT06590831 | N/A | Jun 10, 2023 | Al Azhar University |
| NCT07287384 | N/A | Mar 1, 2023 | University of Turin |
| NCT05714176 | Phase 4 | Feb 1, 2023 | Menoufia University, Tanta University |
| NCT05519254 | Phase 3 | Jan 31, 2023 | National Institutes of Health (NIH), University of Washington |
| NCT05434104 | N/A | Oct 31, 2022 | Statens Serum Institut, University of London |
| NCT05431023 | N/A | Aug 1, 2022 | Assiut University |
| NCT05669963 | Phase 2/Phase 3 (Phase 3) | Jul 1, 2022 | Zagazig University |
| NCT05760079 | N/A | Jun 30, 2022 | Wake Forest University |
| NCT05233709 | N/A | Apr 25, 2022 | Swiss Federal Institute of Technology |
| NCT05038462 | N/A | Sep 30, 2021 | Fundació Sant Joan de Déu, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona |
| NCT04810546 | N/A | Jul 1, 2021 | National Heart, Lung, and Blood Institute (NHLBI), University of Illinois at Chicago |
| NCT04865796 | N/A | May 15, 2021 | University of Pavia |
Showing 20 of 64 trials
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Organizations
Research & Development (61)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Ain Shams University | Academic/Hospital | 5 | 5 | 3 | 2014 |
| Cairo University | Academic/Hospital | 5 | 5 | 3 | 2018 |
| Ventria Bioscience | For profit | 4 | 1 | 3 | 2005 |
| Assiut University | Academic/Hospital | 3 | 3 | 2 | 2017 |
| Tanta University | Academic/Hospital | 3 | 2 | 3 | 2023 |
| Helaina Inc. | For profit | 2 | 1 | 1 | 2023 |
| Johns Hopkins University | Academic/Hospital | 2 | 2 | 2 | 2005 |
| South Valley University | Academic/Hospital | 2 | 2 | 1 | 2018 |
| Swiss Federal Institute of Technology | Academic/Hospital | 2 | 2 | 1 | 2018 |
| The Gerber Foundation | Academic/Hospital | 2 | 0 | 1 | 2016 |
| University of Ferrara | Academic/Hospital | 2 | 2 | 2 | 2011 |
| University of Pavia | Academic/Hospital | 2 | 2 | 1 | 2021 |
| University of Virginia | Academic/Hospital | 2 | 2 | 1 | 2016 |
| Zagazig University | Academic/Hospital | 2 | 2 | 2 | 2020 |
| Agennix | For profit | 1 | 1 | 1 | 2004 |
| Al Azhar University | Academic/Hospital | 1 | 0 | 1 | 2023 |
| AM-Pharma | For profit | 1 | 1 | 1 | 2008 |
| Beingmate Baby & Child Food Co Ltd . | For profit | 1 | 1 | 1 | 2016 |
| Cayetano Heredia University | Academic/Hospital | 1 | 1 | 1 | 2010 |
| Clinica Fabia Mater | Academic/Hospital | 1 | 1 | 1 | 2010 |
61 organizations
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