EGFR

SINGLE PROTEINHomo sapiens

Preferred name: Epidermal growth factor receptor erbB1 ChEMBL ↗

Linked proteins

Epidermal growth factor receptor (EGFR) ↗

Drugs acting on this target (250)

Active Pharmaceutical Ingredient	Mechanism Type ▲	Approval Status	API Type	Mechanism of Action
bdtx-1535	Antagonist	experimental	Small molecule	EGFR
blu-451	Antagonist	experimental	Small molecule	EGFR antagonist
eras-801	Antagonist	experimental	Small molecule	EGFR
futuximab	Antagonist	experimental	mAb	EGFR antagonist
gnc-039	Antagonist	experimental	mAb	EGFR antagonist
hlx35	Antagonist	experimental	mAb	egfr
hs-10375	Antagonist	experimental	Small molecule	EGFR
hs-10376	Antagonist	experimental	Small molecule	EGFR
ht-001	Antagonist	experimental	Small molecule	EGFR
imgatuzumab	Antagonist	experimental	mAb	EGFR antagonist
jin-a02	Antagonist	experimental	Small molecule	EGFR antagonist
m1231	Antagonist	experimental	mAb	EGFR
mAb 425	Antagonist	experimental	mAb	EGFR
MCLA-129	Antagonist	experimental	mAb	EGFR
modotuximab	Antagonist	experimental	mAb	Epidermal growth factor receptor erbB1 antagonist
nrc-2694-a	Antagonist	experimental	Small molecule	EGFR
nx-019	Antagonist	experimental	Small molecule	egfr
sph1188-11	Antagonist	experimental	Small molecule	EGFR antagonist
tq-b3395	Antagonist	experimental	Small molecule	EGFR antagonist
tqb3456	Antagonist	experimental	Small molecule	EGFR antagonist
zalutumumab	Antagonist	experimental	mAb	EGFR antagonist
bb-401	Antisense inhibitor	experimental	Nucleic acid	EGFR antisense inhibitor
aby-029	Binding agent	experimental	Small molecule	EGFR binding agent
cpo301	Binding agent	experimental	mAb	EGFR binding agent
cx-904	Binding agent	experimental	mAb	EGFR
depatuxizumab mafodotin	Binding agent	experimental	mAb	EGFR binding agent
egfr(v)-edv-dox	Binding agent	experimental	Small molecule	EGFR binding agent
hegfrviii-cd3	Binding agent	experimental	mAb	EGFR binding agent
iae0972	Binding agent	experimental	Recombinant protein	EGFR binding agent
Losatuxizumab vedotin	Binding agent	experimental	mAb	Epidermal growth factor receptor binding agent
MDX-214	Binding agent	experimental	mAb	EGFR
mrg003	Binding agent	experimental	mAb	EGFR
MVC-101	Binding agent	experimental	mAb	EGFR
ods2004436	Binding agent	experimental	Small molecule	EGFR binding agent
sgn-egfrd2	Binding agent	experimental	mAb	EGFR binding agent
mdx447	Cross-linking agent	experimental	mAb	Epidermal growth factor receptor erbB1 cross-linking agent
cft8919	Degrader	experimental	Small molecule	EGFR degrader
ch806	Immunity, active	experimental	mAb	EGFR immunity, active
rindopepimut (Rintega)	Immunity, active	experimental	Vaccine	EGFR immunity, active
a2b395	Immunity, passive	experimental	Cell therapy	EGFR immunity, passive
abt-806	Immunity, passive	experimental	mAb	EGFR immunity, passive
ace2016	Immunity, passive	experimental	Cell therapy	EGFR immunity, passive
ad5-cmv-nis	Immunity, passive	experimental	Cell therapy	EGFR immunity, passive
anti-egfr car t cells	Immunity, passive	experimental	Cell therapy	EGFR immunity, passive
anti-egfrviii car transduced pbl	Immunity, passive	experimental	Cell therapy	EGFR immunity, passive
autologous cd123car-cd28-cd3zeta-egfrt-expressing t lymphocytes	Immunity, passive	experimental	Cell therapy	EGFR immunity, passive
cart-egfr	Immunity, passive	experimental	Cell therapy	EGFR immunity, passive
cart-egfrviii t cells	Immunity, passive	experimental	Cell therapy	EGFR immunity, passive
cartemis	Immunity, passive	experimental	Cell therapy	EGFR immunity, passive
carv3-team-e t cells	Immunity, passive	experimental	Cell therapy	EGFR immunity, passive
cd123car-41bb-cd3zeta-egfrt-expressing t cells	Immunity, passive	experimental	Cell therapy	EGFR immunity, passive
cd19car-cd28-cd3zeta-egfrt-expressing tcm-enriched t-lymphocytes	Immunity, passive	experimental	Cell therapy	EGFR immunity, passive
cd22-specific car t-cells also expressing an egfrt	Immunity, passive	experimental	Cell therapy	EGFR immunity, passive
cxcr5 modified egfr chimeric antigen receptor autologous t cells	Immunity, passive	experimental	Cell therapy	EGFR immunity, passive
egfr bats	Immunity, passive	experimental	Cell therapy	EGFR immunity, passive
EGFR Bi-armed Activated T-cells	Immunity, passive	experimental	Cell therapy	EGFR immunity, passive
egfr cart	Immunity, passive	experimental	Cell therapy	EGFR immunity, passive
egfr fpbmc	Immunity, passive	experimental	Cell therapy	EGFR immunity, passive
EGFR-BATs	Immunity, passive	experimental	Cell therapy	EGFR immunity, passive
egfr/b7h3 car-t	Immunity, passive	experimental	Cell therapy	EGFR immunity, passive
egfr806 car-t cell	Immunity, passive	experimental	Cell therapy	EGFR immunity, passive
egfrbi armed atc infusions	Immunity, passive	experimental	Cell therapy	EGFR immunity, passive
egfrbi-armed autologous activated t cells	Immunity, passive	experimental	Cell therapy	EGFR immunity, passive
egfrbi-armed autologous t cells	Immunity, passive	experimental	Cell therapy	EGFR immunity, passive
egfrt/19-28z/4-1bbl car t cells	Immunity, passive	experimental	Cell therapy	EGFR immunity, passive
egfrviii car t cells	Immunity, passive	experimental	Cell therapy	EGFR immunity, passive
egfrviii-specific hinge-optimized cd3 ζ-stimulatory/41bb-co-stimulatory chimeric antigen receptor autologous t-lymphocytes	Immunity, passive	experimental	Cell therapy	EGFR immunity, passive
herincar-pd1 cells	Immunity, passive	experimental	Cell therapy	EGFR immunity, passive
janx008	Immunity, passive	experimental	Cell therapy	immunity, passive - EGFR
patient derived cd171 specific car t cells expressing egfrt	Immunity, passive	experimental	Cell therapy	EGFR immunity, passive
patient derived cd19 specific car t cells also expressing an egfrt	Immunity, passive	experimental	Cell therapy	EGFR immunity, passive
sc-car4brain	Immunity, passive	experimental	Cell therapy	EGFR immunity, passive
scri-e2car_egfrtv1	Immunity, passive	experimental	Cell therapy	EGFR immunity, passive
tgfβr-ko car-egfr t cells	Immunity, passive	experimental	Cell therapy	EGFR immunity, passive
tils and car-tils targeting her2, mesothelin, psca, muc1, lewis-y, gpc3, axl, egfr, claudin18.2/6, ror1, gd1, or b7-h3	Immunity, passive	experimental	Cell therapy	EGFR immunity, passive
111-indium-ch806	Inhibitor	experimental	mAb	EGFR inhibitor
abbv-321	Inhibitor	experimental	mAb	EGFR inhibitor
abivertinib	Inhibitor	experimental	Small molecule	Epidermal growth factor receptor erbB1 inhibitor
absk112	Inhibitor	experimental	Small molecule	EGFR inhibitor
abt-101	Inhibitor	experimental	Small molecule	EGFR inhibitor
aee-788	Inhibitor	experimental	Small molecule	EGFR inhibitor
afatinib (gilotrif)	Inhibitor	approved	Small molecule	EGFR inhibitor
afm24	Inhibitor	experimental	mAb	EGFR inhibitor
allitinib	Inhibitor	experimental	Small molecule	EGFR inhibitor
ametumumab	Inhibitor	experimental	mAb	EGFR inhibitor
amg 595	Inhibitor	experimental	mAb	EGFR inhibitor
amg 596	Inhibitor	experimental	mAb	EGFR inhibitor
amivantamab-vmjw (Rybrevant)	Inhibitor	approved	mAb	Epidermal growth factor receptor inhibitor
anti-egfr immunoliposomes loaded with doxorubicin	Inhibitor	experimental	mAb	EGFR inhibitor
ap32788	Inhibitor	experimental	Small molecule	EGFR inhibitor
aumolertinib	Inhibitor	experimental	Small molecule	Epidermal growth factor receptor erbB1 inhibitor
av-412	Inhibitor	experimental	Small molecule	EGFR inhibitor
avid100	Inhibitor	experimental	mAb	EGFR inhibitor
avitinib	Inhibitor	experimental	Small molecule	EGFR inhibitor
az-12096971	Inhibitor	experimental	Small molecule	EGFR inhibitor
az7550	Inhibitor	experimental	Small molecule	EGFR inhibitor
azd6234	Inhibitor	experimental	Small molecule	EGFR inhibitor
azd7503	Inhibitor	experimental	Nucleic acid	EGFR inhibitor
azd9592	Inhibitor	experimental	mAb	EGFR inhibitor
b001	Inhibitor	experimental	mAb	EGFR inhibitor
bb-1705	Inhibitor	experimental	mAb	EGFR inhibitor
bbt-176	Inhibitor	experimental	Small molecule	EGFR inhibitor
bbt-207	Inhibitor	experimental	Small molecule	EGFR inhibitor
bca101	Inhibitor	experimental	mAb	EGFR inhibitor
bebt-109	Inhibitor	experimental	Small molecule	EGFR inhibitor
bebt-109	Inhibitor	experimental	Small molecule	EGFR inhibitor
bebt-109	Inhibitor	experimental	Small molecule	EGFR inhibitor
bg-60366	Inhibitor	experimental	Small molecule	EGFR inhibitor
bg-t187	Inhibitor	experimental	Small molecule	EGFR inhibitor
bl-b16d1	Inhibitor	experimental	mAb	EGFR inhibitor
blu-701	Inhibitor	experimental	Small molecule	EGFR inhibitor
blu-945	Inhibitor	experimental	Small molecule	EGFR inhibitor
bms-599626	Inhibitor	experimental	Small molecule	EGFR inhibitor
bms-690514	Inhibitor	experimental	Small molecule	EGFR inhibitor
bpi-15086	Inhibitor	experimental	Small molecule	EGFR inhibitor
br115	Inhibitor	experimental	mAb	EGFR inhibitor
brigatinib (alunbrig)	Inhibitor	approved	Small molecule	EGFR inhibitor
canertinib	Inhibitor	experimental	Small molecule	EGFR inhibitor
CDP1	Inhibitor	experimental	mAb	EGFR inhibitor
cep-32496	Inhibitor	experimental	Small molecule	EGFR inhibitor
cetugex	Inhibitor	experimental	mAb	EGFR inhibitor
cetuximab (erbitux)	Inhibitor	approved	mAb	EGFR inhibitor
cetuximab zr89	Inhibitor	experimental	mAb	EGFR inhibitor
ck-101	Inhibitor	experimental	Small molecule	EGFR inhibitor
ckd-702	Inhibitor	experimental	mAb	EGFR inhibitor
cln-081	Inhibitor	experimental	Small molecule	Epidermal growth factor receptor erbB1 inhibitor
cm93	Inhibitor	experimental	Small molecule	EGFR inhibitor
cpgj602	Inhibitor	experimental	mAb	EGFR inhibitor
cudc-101	Inhibitor	experimental	Small molecule	EGFR inhibitor
d2c7	Inhibitor	experimental	mAb	EGFR inhibitor
dacomitinib (vizimpro)	Inhibitor	approved	Small molecule	EGFR inhibitor
dbpr112	Inhibitor	experimental	Small molecule	EGFR inhibitor
depatuxizumab mafodotin	Inhibitor	experimental	mAb	EGFR inhibitor
df9001	Inhibitor	experimental	mAb	EGFR inhibitor
dihydroxycoumarin (Esculetin)	Inhibitor	experimental	Small molecule	EGFR inhibitor
dk210	Inhibitor	experimental	Small molecule	EGFR inhibitor
dm001	Inhibitor	experimental	mAb	EGFR inhibitor
dm005	Inhibitor	experimental	mAb	EGFR inhibitor
duligotuzumab	Inhibitor	experimental	mAb	EGFR inhibitor
e	Inhibitor	experimental	Small molecule	EGFR inhibitor
egf816	Inhibitor	experimental	Small molecule	EGFR inhibitor
egfr antisense dna	Inhibitor	experimental	Nucleic acid	EGFR inhibitor
emb-01	Inhibitor	experimental	mAb	Epidermal growth factor receptor erbB1 inhibitor
epitinib	Inhibitor	experimental	Small molecule	EGFR inhibitor
erlotinib (tarceva)	Inhibitor	approved	Small molecule	EGFR inhibitor
falnidamol	Inhibitor	experimental	Small molecule	EGFR inhibitor
fcn-411	Inhibitor	experimental	Small molecule	EGFR inhibitor
furmonertinib (Ives)	Inhibitor	experimental	Small molecule	Epidermal growth factor receptor erbB1 inhibitor
futuximab	Inhibitor	experimental	mAb	EGFR inhibitor
gb263t	Inhibitor	experimental	mAb	EGFR inhibitor
gc-1118	Inhibitor	experimental	mAb	Epidermal growth factor receptor erbB1 inhibitor
gefitinib (iressa)	Inhibitor	approved	Small molecule	EGFR inhibitor
hemay102	Inhibitor	experimental	Small molecule	EGFR inhibitor
hlx07	Inhibitor	experimental	mAb	EGFR inhibitor
hlx42	Inhibitor	experimental	mAb	EGFR inhibitor
hs-10504	Inhibitor	experimental	Small molecule	EGFR inhibitor
hs-20117	Inhibitor	experimental	mAb	EGFR inhibitor
hsk40118	Inhibitor	experimental	Small molecule	EGFR inhibitor
hy1272	Inhibitor	experimental	Small molecule	EGFR inhibitor
ibi3001	Inhibitor	experimental	mAb	EGFR inhibitor
ibi334	Inhibitor	experimental	mAb	EGFR inhibitor
icotinib (Conmana)	Inhibitor	experimental	Small molecule	Epidermal growth factor receptor erbB1 inhibitor
imgatuzumab	Inhibitor	experimental	mAb	EGFR inhibitor
imgn289	Inhibitor	experimental	mAb	EGFR inhibitor
incb099318	Inhibitor	experimental	Small molecule	EGFR inhibitor
jmt101	Inhibitor	experimental	mAb	EGFR inhibitor
jnj-26483327	Inhibitor	experimental	Small molecule	EGFR inhibitor
js111	Inhibitor	experimental	Small molecule	EGFR inhibitor
kat-201	Inhibitor	experimental	Small molecule	EGFR inhibitor
keynatinib	Inhibitor	experimental	Small molecule	EGFR inhibitor
kk2260	Inhibitor	experimental	mAb	EGFR inhibitor
lapatinib (tykerb)	Inhibitor	approved	Small molecule	EGFR inhibitor
lazertinib (Lazcluze)	Inhibitor	approved	Small molecule	Epidermal growth factor receptor erbB1 inhibitor
ly3164530	Inhibitor	experimental	mAb	EGFR inhibitor
mab-425	Inhibitor	experimental	mAb	EGFR inhibitor
matuzumab	Inhibitor	experimental	mAb	EGFR inhibitor
Mavelertinib	Inhibitor	experimental	Small molecule	Epidermal growth factor receptor erbB1 inhibitor
mdx447	Inhibitor	experimental	mAb	EGFR inhibitor
mm-151	Inhibitor	experimental	mAb	EGFR inhibitor
mobocertinib (EXKIVITY)	Inhibitor	approved	Small molecule	Epidermal growth factor receptor erbB1 inhibitor
modotuximab	Inhibitor	experimental	mAb	Epidermal growth factor receptor erbB1 inhibitor
mr1-1	Inhibitor	experimental	mAb	EGFR inhibitor
naquotinib	Inhibitor	experimental	Small molecule	Epidermal growth factor receptor erbB1 inhibitor
nazartinib	Inhibitor	experimental	Small molecule	Epidermal growth factor receptor erbB1 inhibitor
necitumumab (portrazza)	Inhibitor	approved	mAb	EGFR inhibitor
neratinib maleate (nerlynx)	Inhibitor	approved	Small molecule	Epidermal growth factor receptor erbB1 inhibitor
nimotuzumab	Inhibitor	experimental	mAb	EGFR inhibitor
olmutinib	Inhibitor	experimental	Small molecule	EGFR inhibitor
oric-114	Inhibitor	experimental	Small molecule	EGFR inhibitor
osimertinib (tagrisso)	Inhibitor	approved	Small molecule	EGFR inhibitor
panitumumab (vectibix)	Inhibitor	approved	mAb	EGFR inhibitor
pelitinib	Inhibitor	experimental	Small molecule	EGFR inhibitor
pemtumomab	Inhibitor	experimental	mAb	EGFR inhibitor
petosemtamab	Inhibitor	experimental	mAb	EGFR inhibitor
pf-06459988	Inhibitor	experimental	Small molecule	Epidermal growth factor receptor erbB1 inhibitor
ph009-1	Inhibitor	experimental	Small molecule	EGFR inhibitor
pki-166	Inhibitor	experimental	Small molecule	EGFR inhibitor
plb1004	Inhibitor	experimental	Small molecule	EGFR inhibitor
pm54	Inhibitor	experimental	Small molecule	EGFR inhibitor
ps101	Inhibitor	experimental	Small molecule	EGFR inhibitor
puquitinib	Inhibitor	experimental	Small molecule	EGFR inhibitor
pyrotinib	Inhibitor	experimental	Small molecule	EGFR inhibitor
pyrrolitinib	Inhibitor	experimental	Small molecule	EGFR inhibitor
qlh11811	Inhibitor	experimental	Small molecule	EGFR inhibitor
qrh-882260	Inhibitor	experimental	Peptide	EGFR inhibitor
ro7428731	Inhibitor	experimental	Small molecule	EGFR inhibitor
rociletinib	Inhibitor	experimental	Small molecule	EGFR inhibitor
s-222611	Inhibitor	experimental	Small molecule	EGFR inhibitor
sapitinib	Inhibitor	experimental	Small molecule	EGFR inhibitor
sct200	Inhibitor	experimental	mAb	EGFR inhibitor
selatinib ditosilate	Inhibitor	experimental	Small molecule	EGFR inhibitor
sevabertinib	Inhibitor	approved	Small molecule	EGFR inhibitor
shr1258	Inhibitor	experimental	Small molecule	EGFR inhibitor
si-b001	Inhibitor	experimental	mAb	EGFR inhibitor
simotinib	Inhibitor	experimental	Small molecule	EGFR inhibitor
simotinib	Inhibitor	experimental	Small molecule	EGFR inhibitor
smet12	Inhibitor	experimental	mAb	EGFR inhibitor
sparc1023	Inhibitor	experimental	Small molecule	EGFR inhibitor
ssgj-707	Inhibitor	experimental	mAb	EGFR inhibitor
stx-721	Inhibitor	experimental	Small molecule	EGFR inhibitor
sunvozertinib (Zegfrovy)	Inhibitor	approved	Small molecule	EGFR inhibitor
sym013	Inhibitor	experimental	mAb	EGFR inhibitor
syn125	Inhibitor	experimental	mAb	EGFR inhibitor
tak285	Inhibitor	experimental	Small molecule	EGFR inhibitor
targomirs	Inhibitor	experimental	Small molecule	EGFR inhibitor
tarloxotinib	Inhibitor	experimental	Small molecule	EGFR inhibitor
tas2940	Inhibitor	experimental	Small molecule	EGFR inhibitor
tas3351	Inhibitor	experimental	Small molecule	EGFR inhibitor
tavo412	Inhibitor	experimental	Small molecule	EGFR inhibitor
tcmdc-140940	Inhibitor	experimental	Small molecule	EGFR inhibitor
tesevatinib	Inhibitor	experimental	Small molecule	EGFR inhibitor
theliatinib	Inhibitor	experimental	Small molecule	EGFR inhibitor
tomuzotuximab	Inhibitor	experimental	mAb	Epidermal growth factor receptor erbB1 inhibitor
tqb3804	Inhibitor	experimental	Small molecule	EGFR inhibitor
trq15-01	Inhibitor	experimental	mAb	EGFR inhibitor
trx-221	Inhibitor	experimental	Small molecule	EGFR inhibitor
Tuxobertinib	Inhibitor	experimental	Small molecule	EGFR inhibitor
varlitinib	Inhibitor	experimental	Small molecule	EGFR inhibitor
wj13404	Inhibitor	experimental	Small molecule	EGFR inhibitor
wsd0922-fu	Inhibitor	experimental	Small molecule	EGFR inhibitor
xzp-5809-tt1	Inhibitor	experimental	Small molecule	EGFR inhibitor
yk-029a	Inhibitor	experimental	Small molecule	EGFR inhibitor
yk-209a	Inhibitor	experimental	Small molecule	EGFR inhibitor
zalutumumab	Inhibitor	experimental	mAb	EGFR inhibitor
zz06	Inhibitor	experimental	Small molecule	EGFR inhibitor
Tuxobertinib	Negative allosteric modulator	experimental	Small molecule	Epidermal growth factor receptor erbB1 negative allosteric modulator
mdx447	Other	experimental	mAb	EGFR other
[225ac]-fpi-2068	Radiodepletion	experimental	Small molecule	EGFR radiodepletion
fluorodeoxythymidine	Radiopharmaceutical	experimental	Small molecule	EGFR radiopharmaceutical
rindopepimut (Rintega)	Vaccine antigen	experimental	Vaccine	Epidermal growth factor receptor erbB1 vaccine antigen